{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:03:31Z","timestamp":1790874211322,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000400"],"award-info":[{"award-number":["82000400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008766","name":"Fujian Agriculture and Forestry University","doi-asserted-by":"publisher","award":["KFB24058"],"award-info":[{"award-number":["KFB24058"]}],"id":[{"id":"10.13039\/501100008766","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jes.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:49:55Z","timestamp":1762274995000},"page":"277-293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Protective effects of ganoderic acid C2 from Ganoderma lucidum against aflatoxin B1-induced splenorenal injury: Inhibition of NOX4-mediated oxidative stress and inflammation"],"prefix":"10.1016","volume":"169","author":[{"given":"Shangpeng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaole","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zumin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3207-6856","authenticated-orcid":false,"given":"Hui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jes.2025.11.005_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144781","article-title":"Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats","volume":"768","author":"Abdel-Daim","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2025.11.005_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422363","article-title":"Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo","volume":"15","author":"Abdelmoaty","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jes.2025.11.005_bib0003","doi-asserted-by":"crossref","first-page":"tfae083","DOI":"10.1093\/toxres\/tfae083","article-title":"Antioxidant, anti-inflammatory, and anti-DNA damage effects of carnosic acid against aflatoxin B1-induced hepatic, renal, and cardiac toxicities in rats","volume":"13","author":"Albadrani","year":"2024","journal-title":"Toxicol. Res. (Camb)."},{"key":"10.1016\/j.jes.2025.11.005_bib0004","doi-asserted-by":"crossref","first-page":"17561","DOI":"10.1007\/s00210-025-04264-y","article-title":"Piceatannol protects against cisplatin-induced ovarian toxicity in rats via modulation of PTEN\/PI3 K\/AKT axis","volume":"398","author":"Alorabi","year":"2025","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.jes.2025.11.005_bib0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/ijerph17020423","article-title":"Chronic and acute toxicities of aflatoxins: mechanisms of action","volume":"17","author":"Benkerroum","year":"2020","journal-title":"Int. J. Environ. Res. Public Health."},{"key":"10.1016\/j.jes.2025.11.005_bib0006","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jcb.240531041","article-title":"Oltipraz: a laboratory and clinical review","volume":"17F","author":"Benson","year":"1993","journal-title":"J. Cell Biochem. Suppl."},{"key":"10.1016\/j.jes.2025.11.005_bib0007","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/15376516.2021.2021339","article-title":"Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development","volume":"32","author":"Cao","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.jes.2025.11.005_bib0008","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.3390\/foods13172760","article-title":"Synthesis of ganoderic acids loaded Zein-Chitosan nanoparticles and evaluation of their hepatoprotective effect on mice given excessive alcohol","volume":"13","author":"Cao","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jes.2025.11.005_bib0009","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/0748233713500819","article-title":"Effects of aflatoxin B1 on oxidative stress markers and apoptosis of spleens in broilers","volume":"32","author":"Chen","year":"2016","journal-title":"Toxicol. Ind. Health."},{"key":"10.1016\/j.jes.2025.11.005_bib0010","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/toxics13040258","article-title":"BRD4 Mediates cadmium-induced oxidative stress and kidney injury in mice via disruption of redox homeostasis","volume":"13","author":"Chen","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.jes.2025.11.005_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117069","article-title":"Ganoderic acid T, a Ganoderma triterpenoid, modulates the tumor microenvironment and enhances the chemotherapy and immunotherapy efficacy through downregulating galectin-1 levels","volume":"491","author":"Chen","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jes.2025.11.005_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.109757","article-title":"Photocatalytic degradation of aflatoxin B1 in aqueous medium and non-alcoholic beer using chlorophyllin","volume":"150","author":"Dousti","year":"2023","journal-title":"Food Control"},{"key":"10.1016\/j.jes.2025.11.005_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156747","article-title":"Apocynin alleviates thioacetamide-induced acute liver injury: role of NOX1\/NOX4\/NF-\u03bab\/NLRP3 pathways","volume":"183","author":"El-Kashef","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.jes.2025.11.005_bib0014","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1515\/med-2024-0907","article-title":"Aflatoxin B1 induces infertility, fetal deformities, and potential therapies","volume":"19","author":"Francis","year":"2024","journal-title":"Open Med."},{"key":"10.1016\/j.jes.2025.11.005_bib0015","first-page":"430","article-title":"Nox4 is involved in acute kidney injury associated to intravascular hemolysis. Free Radic","volume":"225","author":"Garc\u00eda-Caballero","year":"2024","journal-title":"Biol. Med."},{"key":"10.1016\/j.jes.2025.11.005_bib0016","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s43586-022-00184-w","article-title":"Principal component analysis","volume":"2","author":"Greenacre","year":"2022","journal-title":"Nat. Rev. Methods Primers."},{"key":"10.1016\/j.jes.2025.11.005_bib0017","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2147\/DDDT.S249093","article-title":"Suppression of cisplatin-induced hepatic injury in rats through Alarmin high-mobility group Box-1 pathway by Ganoderma lucidum: theoretical and experimental study","volume":"14","author":"Hassan","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.jes.2025.11.005_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1513105","article-title":"Post-treatment of rat aflatoxicosis by camel milk and silymarin","volume":"16","author":"Hassaneen","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jes.2025.11.005_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09890","article-title":"The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1","volume":"8","author":"Hatipoglu","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.jes.2025.11.005_bib0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-70623-z","article-title":"Ameliorative effects of silymarin on aflatoxin B1 toxicity in weaned rabbits: impact on growth, blood profile, and oxidative stress","volume":"14","author":"Imbabi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jes.2025.11.005_bib0021","first-page":"257","article-title":"Oltipraz chemoprevention trial in Qidong, People\u2019s Republic of China: study design and clinical outcomes","volume":"6","author":"Jacobson","year":"1997","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.jes.2025.11.005_bib0022","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/jac\/dkx479","article-title":"TGF-\u03b2-mediated NADPH oxidase 4-dependent oxidative stress promotes colistin-induced acute kidney injury","volume":"73","author":"Jeong","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jes.2025.11.005_bib0023","first-page":"2170","article-title":"Aflatoxins: a global concern for food safety, Human health and their management","volume":"7","author":"Kumar","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jes.2025.11.005_bib0024","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/carcin\/18.7.1343","article-title":"Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture","volume":"18","author":"Langouet","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jes.2025.11.005_bib0025","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/biom12091188","article-title":"Effect of Curcumin as feed supplement on immune response and pathological changes of broilers exposed to Aflatoxin B1","volume":"12","author":"Li","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jes.2025.11.005_bib0026","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1021\/acs.chemrestox.0c00019","article-title":"Effects of Arsenic on wnt\/\u03b2-catenin signaling pathway: a systematic review and meta-analysis","volume":"33","author":"Li","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jes.2025.11.005_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117997","article-title":"Diosmetin alleviates AFB1-induced endoplasmic reticulum stress, autophagy, and apoptosis via PI3K\/AKT pathway in mice","volume":"292","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2025.11.005_bib0028","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/tox.22395","article-title":"The aflatoxin B1 -fumonisin B1 toxicity in BRL-3A hepatocytes is associated to induction of cytochrome P450 activity and arachidonic acid metabolism","volume":"32","author":"Mary","year":"2017","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jes.2025.11.005_bib0029","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2017.10.234","article-title":"Regulation of \u03b2-TrCP mediated Nrf2 degradation by GSK3\u03b2 during hyperglycemic renal toxicity","volume":"112","author":"Mathur","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jes.2025.11.005_bib0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/labinvest.2017.120","article-title":"NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation","volume":"98","author":"Meng","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.jes.2025.11.005_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135594","article-title":"Mitigating CYP3A4-mediated aflatoxin toxicity with algal-derived Sodium Copper Chlorophyllin: production and In-silico insights","volume":"280","author":"Mishra","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jes.2025.11.005_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153983","article-title":"Aflatoxin B1-induced hepatotoxicity through mitochondrial dysfunction, oxidative stress, and inflammation as central pathological mechanisms: a review of experimental evidence","volume":"509","author":"Moloi","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.jes.2025.11.005_bib0033","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03bab signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.jes.2025.11.005_bib0034","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/toxins16080356","article-title":"Mitigation of deoxynivalenol (DON)- and aflatoxin B1 (AFB1)-induced immune dysfunction and apoptosis in mouse spleen by Curcumin","volume":"16","author":"Muhmood","year":"2024","journal-title":"Toxins"},{"key":"10.1016\/j.jes.2025.11.005_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109779","article-title":"Penthorum chinense Prush extract alleviates aflatoxin B1-induced toxicity, oxidative stress and apoptosis via mediating Nrf2 signaling pathway in the Bursa of Fabricius of broilers","volume":"275","author":"Nabi","year":"2024","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.jes.2025.11.005_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110395","article-title":"The efficacy and effect on gut microbiota of an aflatoxin binder and a fumonisin esterase using an in vitro simulator of the human intestinal microbial ecosystem (SHIME\u00ae)","volume":"145","author":"Neckermann","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jes.2025.11.005_bib0037","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.3390\/ijms25105305","article-title":"AFB1 Toxicity in Human food and animal feed consumption: a review of experimental treatments and preventive measures","volume":"25","author":"Po\u017carska","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jes.2025.11.005_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1085818","article-title":"New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs","volume":"14","author":"R\u00e1duly","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jes.2025.11.005_bib0039","doi-asserted-by":"crossref","first-page":"tfae060","DOI":"10.1093\/toxres\/tfae060","article-title":"Modulatory potential of Bacopa monnieri against aflatoxin B1 induced biochemical, molecular and histological alterations in rats","volume":"13","author":"Rathour","year":"2024","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jes.2025.11.005_bib0040","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/jpp\/rgae133","article-title":"Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection","volume":"76","author":"Raza","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jes.2025.11.005_bib0041","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/toxins14120840","article-title":"Aflatoxin B1 exposure in sheep: insights into hepatotoxicity based on oxidative stress, inflammatory injury, apoptosis, and gut microbiota analysis","volume":"14","author":"Sui","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.jes.2025.11.005_bib0042","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1615\/IntJMedMushrooms.2024052871","article-title":"Strategies to increase the production of triterpene acids in Ligzhi or Reishi Medicinal mushroom (Ganoderma lucidum, Agaricomycetes): a review","volume":"26","author":"Sun","year":"2024","journal-title":"Int. J. Med. Mushrooms."},{"key":"10.1016\/j.jes.2025.11.005_bib0043","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/toxsci\/kfw065","article-title":"Generation of a new model rat: nrf2 knockout rats are sensitive to aflatoxin B1 toxicity","volume":"152","author":"Taguchi","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jes.2025.11.005_bib0044","article-title":"Embelin attenuates lipopolysaccharide-induced acute kidney injury through the inhibition of M1 macrophage activation and NF-\u03bab signaling in mice","volume":"9","author":"Tang","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jes.2025.11.005_bib0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.fct.2017.07.051","article-title":"The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits","volume":"108","author":"Taofiq","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jes.2025.11.005_bib0046","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190301","article-title":"Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice","volume":"39","author":"Wan","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jes.2025.11.005_bib0047","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.toxicon.2022.01.010","article-title":"Curcumin activates the Nrf2 Pathway to alleviate AFB1-induced immunosuppression in the spleen of ducklings","volume":"209","author":"Wan","year":"2022","journal-title":"Toxicon"},{"key":"10.1016\/j.jes.2025.11.005_bib0048","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/19440049.2019.1662493","article-title":"A high capacity bentonite clay for the sorption of aflatoxins","volume":"37","author":"Wang","year":"2020","journal-title":"Food Addit. Contam. Part. A"},{"key":"10.1016\/j.jes.2025.11.005_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126017","article-title":"Magnolol protects C6 glioma cells against neurotoxicity of FB1 via modulating PI3K\/Akt and mitochondria-associated apoptosis signaling pathways","volume":"372","author":"Wang","year":"2025","journal-title":"Environ Pollut."},{"key":"10.1016\/j.jes.2025.11.005_bib0050","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/antiox11061082","article-title":"Alleviation of oral exposure to aflatoxin B1-induced renal dysfunction, oxidative stress, and cell apoptosis in mice kidney by Curcumin","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jes.2025.11.005_bib0051","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/ajcn\/80.5.1106","article-title":"Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions","volume":"80","author":"Williams","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jes.2025.11.005_bib0052","first-page":"71","article-title":"MicroRNA-126 enhances the biological function of endothelial progenitor cells under oxidative stress via PI3K\/Akt\/GSK3\u03b2 and ERK1\/2 signaling pathways","volume":"21","author":"Wu","year":"2021","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.jes.2025.11.005_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112213","article-title":"AFB1-induced mice liver injury involves mitochondrial dysfunction mediated by mitochondrial biogenesis inhibition","volume":"216","author":"Xu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2025.11.005_bib0054","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3390\/antiox12020306","article-title":"Aflatoxin B1 induced oxidative stress and gut microbiota disorder to increase the infection of cyprinid herpesvirus 2 in gibel carp (Carassius auratus gibelio)","volume":"12","author":"Xue","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jes.2025.11.005_bib0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxrep.2023.01.006","article-title":"Ochratoxin A induces endoplasmic reticulum stress and fibrosis in the kidney via the HIF-1\u03b1\/miR-155-5p link","volume":"10","author":"Yang","year":"2023","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.jes.2025.11.005_bib0056","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.rvsc.2018.07.007","article-title":"Aflatoxin B1 induced renal and cardiac damage in rats: protective effect of lycopene","volume":"119","author":"Yilmaz","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.jes.2025.11.005_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103794","article-title":"Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-\u03bab signaling pathway in mice spinal cords","volume":"90","author":"Zhou","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074225007181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074225007181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:20:07Z","timestamp":1790871607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074225007181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":57,"alternative-id":["S1001074225007181"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2025.11.005","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of ganoderic acid C2 from Ganoderma lucidum against aflatoxin B1-induced splenorenal injury: Inhibition of NOX4-mediated oxidative stress and inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}