{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:04:45Z","timestamp":1784898285316,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330101"],"award-info":[{"award-number":["82330101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8233010"],"award-info":[{"award-number":["8233010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jes.2025.12.074","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:37:30Z","timestamp":1766734650000},"page":"813-825","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fine particulate matter promoted vascular calcification through the miR-27b-5p\/HES1 signaling pathway"],"prefix":"10.1016","volume":"167","author":[{"given":"Ruiyang","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanglin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4470-9743","authenticated-orcid":false,"given":"Zhiwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jes.2025.12.074_bib0001","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.taap.2018.08.014","article-title":"Acute and 28-day sub-acute intravenous toxicity studies of 1\u2032-S-1\u2032-acetoxychavicol acetate in rats","volume":"356","author":"Abdalla","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"8","key":"10.1016\/j.jes.2025.12.074_bib0002","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/cvr\/cvaa255","article-title":"A combined microRNA and target protein-based panel for predicting the probability and severity of uraemic vascular calcification: a translational study","volume":"117","author":"Chao","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"10440","key":"10.1016\/j.jes.2025.12.074_bib0003","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(24)00933-4","article-title":"Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jes.2025.12.074_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102681","article-title":"MiR-27b attenuates mitochondrial oxidative stress and inflammation in endothelial cells","volume":"62","author":"D'Onofrio","year":"2023","journal-title":"Redox. Biol."},{"issue":"7","key":"10.1016\/j.jes.2025.12.074_bib0005","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/cvr\/cvae082","article-title":"New insight into air pollution-related cardiovascular disease: an adverse outcome pathway framework of PM2.5-associated vascular calcification","volume":"120","author":"Ding","year":"2024","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.jes.2025.12.074_bib0006","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvy010","article-title":"Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness","volume":"114","author":"Durham","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.jes.2025.12.074_bib0007","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/iej.13959","article-title":"Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: an ex vivo study","volume":"56","author":"Guo","year":"2023","journal-title":"Int. Endod. J."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0008","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12989-022-00482-x","article-title":"Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker","volume":"19","author":"Ho","year":"2022","journal-title":"Part. Fibre. Toxicol."},{"issue":"6","key":"10.1016\/j.jes.2025.12.074_bib0009","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1021\/acs.chemrestox.5c00056","article-title":"The role of endoplasmic reticulum stress in fine particulate matter-induced phenotype switching of vascular smooth muscle cells","volume":"38","author":"Huang","year":"2025","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12989-022-00472-z","article-title":"Oxidative stress generated by polycyclic aromatic hydrocarbons from ambient particulate matter enhance vascular smooth muscle cell migration through MMP upregulation and actin reorganization","volume":"19","author":"Ju","year":"2022","journal-title":"Part. Fibre. Toxicol."},{"issue":"13","key":"10.1016\/j.jes.2025.12.074_bib0011","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/eurheartj\/eht426","article-title":"Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study","volume":"35","author":"K\u00e4lsch","year":"2014","journal-title":"Eur. Heart. J."},{"issue":"10045","key":"10.1016\/j.jes.2025.12.074_bib0012","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0140-6736(16)00378-0","article-title":"Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study","volume":"388","author":"Kaufman","year":"2016","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jes.2025.12.074_bib0013","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/CIRCRESAHA.122.321939","article-title":"Circulating extracellular vesicle-propagated microRNA signature as a vascular calcification factor in chronic kidney disease","volume":"132","author":"Koide","year":"2023","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400919","article-title":"In vitro modeling of atherosclerosis using iPSC-derived blood vessel organoids","volume":"14","author":"Kong","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.jes.2025.12.074_bib0015","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1359\/jbmr.060303","article-title":"HES1 cooperates with pRb to activate RUNX2-dependent transcription","volume":"21","author":"Lee","year":"2006","journal-title":"J. Bone. Miner. Res."},{"issue":"4","key":"10.1016\/j.jes.2025.12.074_bib0016","doi-asserted-by":"crossref","first-page":"C362","DOI":"10.1152\/ajpcell.00322.2012","article-title":"Atmospheric ultrafine particles promote vascular calcification via the NF-\u03bab signaling pathway","volume":"304","author":"Li","year":"2013","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.jes.2025.12.074_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103158","article-title":"PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner","volume":"72","author":"Li","year":"2024","journal-title":"Redox. Biol."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0018","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12989-024-00579-5","article-title":"Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p\/HO-1 signaling","volume":"21","author":"Li","year":"2024","journal-title":"Part. Fibre. Toxicol."},{"issue":"2","key":"10.1016\/j.jes.2025.12.074_bib0019","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.atherosclerosis.2011.08.033","article-title":"HGF\/c-met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro","volume":"219","author":"Liu","year":"2011","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.jes.2025.12.074_bib0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/15384047.2015.1016662","article-title":"Hes1: a key role in stemness, metastasis and multidrug resistance","volume":"16","author":"Liu","year":"2015","journal-title":"Cancer. Biol. Ther."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0021","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00438-025-02259-1","article-title":"HES1 in cancer: a key player in tumorigenesis and its prognostic significance","volume":"300","author":"Magesh","year":"2025","journal-title":"Mol. Genet. Genomics."},{"issue":"43","key":"10.1016\/j.jes.2025.12.074_bib0022","doi-asserted-by":"crossref","first-page":"29119","DOI":"10.1074\/jbc.M801774200","article-title":"BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation","volume":"283","author":"Matsubara","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0023","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1074\/jbc.275.1.530","article-title":"The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1","volume":"275","author":"McLarren","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jes.2025.12.074_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102113","article-title":"The mitochondria-targeted antioxidant MitoQ attenuated PM2.5-induced vascular fibrosis via regulating mitophagy","volume":"46","author":"Ning","year":"2021","journal-title":"Redox. Biol."},{"issue":"1\u20132","key":"10.1016\/j.jes.2025.12.074_bib0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10495-019-01580-6","article-title":"Effect of miR-27b-5p on apoptosis of human vascular endothelial cells induced by simulated microgravity","volume":"25","author":"Pan","year":"2020","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0026","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1038\/s41467-023-39797-4","article-title":"Global air pollution exposure and poverty","volume":"14","author":"Rentschler","year":"2023","journal-title":"Nat. Commun."},{"issue":"49","key":"10.1016\/j.jes.2025.12.074_bib0027","doi-asserted-by":"crossref","first-page":"40589","DOI":"10.1074\/jbc.M504166200","article-title":"The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin","volume":"280","author":"Shen","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jes.2025.12.074_bib0028","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s10616-025-00759-x","article-title":"Circular RNA-Sirt1 sponges miR-27b-3p to protect vascular smooth muscle cell injury during atherosclerosis through regulating the glutamine metabolism pathway","volume":"77","author":"Song","year":"2025","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jes.2025.12.074_bib0029","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jes.2020.12.007","article-title":"Application of a real-ambient fine particulate matter exposure system on different animal models","volume":"105","author":"Song","year":"2021","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.jes.2025.12.074_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113410","article-title":"Rutin ameliorates the promotion effect of fine particulate matter on vascular calcification in calcifying vascular cells and ApoE-\/- mice","volume":"234","author":"Su","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0031","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2007.12.100","article-title":"Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation","volume":"367","author":"Suh","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.jes.2025.12.074_bib0032","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/CIRCRESAHA.112.267237","article-title":"Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification","volume":"111","author":"Sun","year":"2012","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.jes.2025.12.074_bib0033","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s11427-021-1967-x","article-title":"Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway","volume":"65","author":"Wang","year":"2022","journal-title":"Sci. China Life Sci."},{"issue":"6","key":"10.1016\/j.jes.2025.12.074_bib0034","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.6553","article-title":"Association of estimated long-term exposure to air pollution and traffic proximity with a marker for coronary atherosclerosis in a nationwide study in China","volume":"2","author":"Wang","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"3","key":"10.1016\/j.jes.2025.12.074_bib0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s13577-018-0208-z","article-title":"Atrial overexpression of microRNA-27b attenuates angiotensin II-induced atrial fibrosis and fibrillation by targeting ALK5","volume":"31","author":"Wang","year":"2018","journal-title":"Hum. Cell."},{"key":"10.1016\/j.jes.2025.12.074_bib0036","unstructured":"WHO (World Health Organization), 2021. WHO Guidelines Approved By the Guidelines Review Committee, WHO global air quality guidelines: Particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. Available at: https:\/\/www.who.int\/publications\/i\/item\/9789240034228\/."},{"key":"10.1016\/j.jes.2025.12.074_bib44","unstructured":"WHO (World Health Organization), 2024. Ambient (outdoor) air pollution. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/ambient-(outdoor)-air-quality-and-health. Accessed October 24, 2024."},{"issue":"11","key":"10.1016\/j.jes.2025.12.074_bib0037","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1038\/s41596-019-0213-z","article-title":"Generation of blood vessel organoids from human pluripotent stem cells","volume":"14","author":"Wimmer","year":"2019","journal-title":"Nat. Protoc."},{"issue":"9","key":"10.1016\/j.jes.2025.12.074_bib0038","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.7150\/ijbs.16430","article-title":"Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells through the Notch3-HES1\/2\/5 pathway","volume":"12","author":"Wu","year":"2016","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.jes.2025.12.074_bib0039","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/cvr\/cvae035","article-title":"Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification","volume":"120","author":"Xie","year":"2024","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.jes.2025.12.074_bib0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1161\/CIRCRESAHA.121.319745","article-title":"Unspliced XBP1 counteracts \u03b2-catenin to inhibit vascular calcification","volume":"130","author":"Yang","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.jes.2025.12.074_bib0041","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fct.2013.12.041","article-title":"Toxicological assessment of combined lead and cadmium: acute and sub-chronic toxicity study in rats","volume":"65","author":"Yuan","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jes.2025.12.074_bib0042","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.scitotenv.2017.02.149","article-title":"1H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation","volume":"589","author":"Zhang","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.jes.2025.12.074_bib0043","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s12872-025-04724-6","article-title":"Global cardiovascular disease burden attributable to particulate matter pollution, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2045","volume":"25","author":"Zhao","year":"2025","journal-title":"BMC Cardiovasc. Disord."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074225008563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074225008563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:37:32Z","timestamp":1784896652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074225008563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"alternative-id":["S1001074225008563"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2025.12.074","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fine particulate matter promoted vascular calcification through the miR-27b-5p\/HES1 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2025.12.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}