{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:22:40Z","timestamp":1792848160441,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jes.2026.01.086","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:33:12Z","timestamp":1770078792000},"page":"680-689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Simultaneously PYCR-1 and ALH-6 inhibition exacerbates 6-PPD quinone toxicity via disrupting proline and glutamate metabolisms and activating insulin signals in Caenorhabditis elegans"],"prefix":"10.1016","volume":"168","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-7427","authenticated-orcid":false,"given":"Dayong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jes.2026.01.086_bib0001","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.jes.2026.01.086_bib0002","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1021\/acs.est.1c07376","article-title":"New evidence of rubber-derived quinones in water, air, and soil","volume":"56","author":"Cao","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2026.01.086_bib0003","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1021\/acs.est.4c01106","article-title":"In vitro and in vivo biotransformation profiling of 6PPD-quinone toward their detection in human urine","volume":"58","author":"Deng","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2026.01.086_bib0004","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3389\/fpls.2020.01127","article-title":"How does proline treatment promote salt stress tolerance during crop plant development?","volume":"11","author":"El Moukhtari","year":"2020","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jes.2026.01.086_bib0005","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.3390\/cells12222640","article-title":"Proline and proline analogues improve development of mouse preimplantation embryos by protecting them against oxidative stress","volume":"12","author":"Hardy","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jes.2026.01.086_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164842","article-title":"Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB\/c mice","volume":"894","author":"He","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2026.01.086_bib0007","doi-asserted-by":"crossref","first-page":"40","DOI":"10.20517\/jeea.2025.66","article-title":"6-PPD quinone inhibited retinoic acid synthesis mediates toxicity through feedback loop between ALH-3\/DHS-19-SEX-1 axis and intestinal signals in Caenorhabditis elegans","volume":"4","author":"Hu","year":"2025","journal-title":"J. Environ. Expo. Assess."},{"key":"10.1016\/j.jes.2026.01.086_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132265","article-title":"Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity","volume":"459","author":"Hua","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jes.2026.01.086_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176275","article-title":"6-PPD quinone at environmentally relevant concentrations induced damage on longevity in C. elegans: mechanistic insight from inhibition in mitochondrial UPR response","volume":"954","author":"Hua","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.jes.2026.01.086_bib0010","first-page":"1928","article-title":"An environmentally relevant concentration of 6-PPD quinone inhibits two types of mitophagy to cause mitochondrial dysfunction and lifespan reduction in Caenorhabditis elegans","volume":"27","author":"Hua","year":"2025","journal-title":"Environ. Sci.: Processes Impacts"},{"key":"10.1016\/j.jes.2026.01.086_bib0011","article-title":"6-PPD quinone causes alteration in ubiquinone-mediated complex III associated with toxicity on mitochondrial function and longevity in Caenorhabditis elegans","volume":"13","author":"Hua","year":"2025","journal-title":"J. Environ. Chem. Engineer."},{"key":"10.1016\/j.jes.2026.01.086_bib0012","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/j.enceco.2025.10.012","article-title":"6-PPD quinone at environmentally relevant concentrations activates feedback response of electron transport chain to mediate damage on mitochondrial function and longevity in Caenorhabditis elegans","volume":"7","author":"Hua","year":"2025","journal-title":"Environ. Chem. Ecotoxicol."},{"key":"10.1016\/j.jes.2026.01.086_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134598","article-title":"Exposure to 6-PPD quinone causes damage on mitochondrial complex I\/II associated with lifespan reduction in Caenorhabditis elegans","volume":"472","author":"Hua","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jes.2026.01.086_bib0014","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1021\/acs.est.4c11156","article-title":"Mass spectrometry imaging unveils the metabolic effect of 6PPD-quinone in exposed mice","volume":"59","author":"Jia","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2026.01.086_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.174449","article-title":"P-phenylenediamine antioxidants and their quinone derivatives: A review of their environmental occurrence, accessibility, potential toxicity, and human exposure","volume":"948","author":"Liang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2026.01.086_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132124","article-title":"Long-term exposure to polystyrene nanoparticles at environmentally relevant concentration causes suppression in heme homeostasis signal associated with transgenerational toxicity induction in Caenorhabditis elegans","volume":"459","author":"Liu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jes.2026.01.086_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143653","article-title":"Transgenerational response of glucose metabolism in Caenorhabditis elegans exposed to 6-PPD quinone","volume":"367","author":"Liu","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2026.01.086_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138815","article-title":"6-PPD quinone induces response of nuclear hormone receptors in the germline associated with formation of reproductive toxicity in Caenorhabditis elegans","volume":"495","author":"Liu","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jes.2026.01.086_bib0019","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0091-679X(08)61399-0","article-title":"DNA transformation","volume":"48","author":"Mello","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.jes.2026.01.086_bib0020","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.3390\/molecules28124808","article-title":"L-proline prevents endoplasmic reticulum stress in microglial cells exposed to L-azetidine-2-carboxylic acid","volume":"28","author":"Piper","year":"2023","journal-title":"Molecules."},{"key":"10.1016\/j.jes.2026.01.086_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117226","article-title":"Paeoniflorin alleviates toxicity and accumulation of 6-PPD quinone by activating ACS-22 in Caenorhabditis elegans","volume":"286","author":"Song","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2026.01.086_bib0022","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/j.celrep.2016.11.038","article-title":"Proline catabolism modulates innate immunity in Caenorhabditis elegans","volume":"17","author":"Tang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jes.2026.01.086_bib0023","first-page":"185","article-title":"A ubiquitous tire rubber\u2013derived chemical induces acute mortality in coho salmon","volume":"371","author":"Tian","year":"2021","journal-title":"Science (1979)"},{"key":"10.1016\/j.jes.2026.01.086_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123835","article-title":"Mixture toxicity of 6PPD-quinone and polystyrene nanoplastics in zebrafish","volume":"348","author":"Varshney","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2026.01.086_bib0025","series-title":"Molecular Toxicology in Caenorhabditis elegans","author":"Wang","year":"2019"},{"key":"10.1016\/j.jes.2026.01.086_bib0026","series-title":"Exposure Toxicology in Caenorhabditis elegans","author":"Wang","year":"2020"},{"key":"10.1016\/j.jes.2026.01.086_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175057","article-title":"Potential human health risk of the emerging environmental contaminant 6-PPD quinone","volume":"949","author":"Wan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2026.01.086_bib0028","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.enceco.2025.05.022","article-title":"6-PPD quinone at environmentally relevant concentrations disrupts citric acid cycle in Caenorhabditis elegans: role of reduction in acetyl CoA and pyruvate contents","volume":"7","author":"Wan","year":"2025","journal-title":"Environ. Chem. Ecotoxicol."},{"key":"10.1016\/j.jes.2026.01.086_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125208","article-title":"Transgenerational intestinal toxicity of 6-PPD quinone in causing ROS production, enhancement in intestinal permeability and suppression in innate immunity in C. elegans","volume":"363","author":"Wang","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2026.01.086_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124600","article-title":"Exposure to 6-PPD quinone enhances glycogen accumulation in Caenorhabditis elegans","volume":"359","author":"Wang","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2026.01.086_bib0031","first-page":"2741","article-title":"Effect of disruption in intestinal barrier function during transgenerational process on nanoplastic toxicity induction in Caenorhabditis elegans","volume":"12","author":"Wang","year":"2025","journal-title":"Environ. Sci.: Nano"},{"key":"10.1016\/j.jes.2026.01.086_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125539","article-title":"6-PPD quinone causes lipid accumulation across multiple generations differentially affected by metabolic sensors and components of COMPASS complex in Caenorhabditis elegans","volume":"366","author":"Wang","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2026.01.086_bib0033","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3390\/toxics13060434","article-title":"Long-term exposure to 6-PPD quinone inhibits glutamate synthesis and glutamate receptor function associated with its toxicity induction in Caenorhabditis elegans","volume":"13","author":"Wang","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.jes.2026.01.086_bib0034","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3390\/toxics13070544","article-title":"Exposure to 6-PPD quinone disrupts adsorption and catabolism of leucine to cause mitochondrial dysfunction in Caenorhabditis elegans","volume":"13","author":"Wang","year":"2025","journal-title":"Toxics"},{"key":"10.1016\/j.jes.2026.01.086_bib0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.toxlet.2025.06.004","article-title":"Multigenerational toxicity and transcriptomic changes induced by environmentally relevant concentrations of microcystin-LR and -RR in Caenorhabditis elegans","volume":"410","author":"Wang","year":"2025","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jes.2026.01.086_bib0036","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jes.2025.10.044","article-title":"6-PPD quinone reduces lifespan by activating a feedback loop between cholesterol transformation related signal and insulin signaling in C. elegans","volume":"166","author":"Wang","year":"2026","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.jes.2026.01.086_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127231","article-title":"Increased S-adenosyl methionine strengthens the suppression in mitochondrial unfolded protein response induced by 6-PPD quinone at environmentally relevant concentrations in Caenorhabditis elegans","volume":"386","author":"Wang","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2026.01.086_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143719","article-title":"6-PPD quinone at environmentally relevant concentrations induces immunosenescenece by causing immunosuppression during the aging process","volume":"368","author":"Wu","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2026.01.086_bib0039","first-page":"2798","article-title":"Environmentally relevant concentrations of 6-PPDQ disrupts vitamin D3 adsorption and receptor function in Caenorhabditis elegans","volume":"27","author":"Wu","year":"2025","journal-title":"Environ. Sci.: Processes Impacts"},{"key":"10.1016\/j.jes.2026.01.086_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126697","article-title":"Photo-aged polylactic acid microplastics causes severe transgenerational decline in reproductive capacity in C. elegans: insight into activation of DNA damage checkpoints affected by multiple germline histone methyltransferases","volume":"382","author":"Wu","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2026.01.086_bib0041","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1021\/acs.est.4c13250","article-title":"Aged biodegradable nanoplastics enhance body accumulation associated with worse neuronal damage in Caenorhabditis elegans","volume":"59","author":"Wu","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2026.01.086_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126352","article-title":"Environmental fate, toxicity, and mitigation of 6PPD and 6PPD-quinone: current understanding and future directions","volume":"375","author":"Yi","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2026.01.086_bib0043","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.3390\/ani12192626","article-title":"Beneficial effect of proline supplementation on goat spermatozoa quality during cryopreservation","volume":"12","author":"Zhang","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.jes.2026.01.086_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118245","article-title":"Profiling of lincRNAs and differential regulatory mechanisms in response to nanoplastic toxicity at environmentally relevant concentrations in Caenorhabditis elegans","volume":"297","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074226001014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074226001014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:31:36Z","timestamp":1788276696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074226001014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"alternative-id":["S1001074226001014"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2026.01.086","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneously PYCR-1 and ALH-6 inhibition exacerbates 6-PPD quinone toxicity via disrupting proline and glutamate metabolisms and activating insulin signals in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2026.01.086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}