{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:53:17Z","timestamp":1774263197316,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jevs.2019.07.007","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T11:29:54Z","timestamp":1563449394000},"page":"80-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Assessment of Noninvasive Low-Frequency Ultrasound as a Means of Treating Injuries to Suspensory Ligaments in Horses: A Research Paper"],"prefix":"10.1016","volume":"80","author":[{"given":"Ugo","family":"Carrozzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Toniato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jevs.2019.07.007_bib1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2746\/0425164044890580","article-title":"Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999","volume":"36","author":"Kasashima","year":"2004","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.07.007_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2746\/042516401776254808","article-title":"Racehorse injuries, clinical problems and fatalities recorded on British racecourses from flat racing and National Hunt racing during 1996, 1997 and 1998","volume":"33","author":"Williams","year":"2001","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.07.007_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.2042-3306.2006.tb05578.x","article-title":"Association of type of sport and performance level with anatomical site of orthopaedic injury diagnosis","volume":"38","author":"Murray","year":"2006","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.07.007_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/evj.12367","article-title":"Prevalence, location and symmetry of noncatastrophic ligamentous suspensory apparatus lesions in California Thoroughbred racehorses, and association of these lesions with catastrophic injuries","volume":"48","author":"Hill","year":"2016","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.07.007_bib5","series-title":"The lowdown on high suspensory disease (proximal suspensory desmitis)","author":"Dyson","year":"2016"},{"key":"10.1016\/j.jevs.2019.07.007_bib6","series-title":"Suspensory ligament injuries in horses","author":"Ferraro","year":"2007"},{"key":"10.1016\/j.jevs.2019.07.007_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.ctep.2007.08.002","article-title":"Pathobiology of tendon and ligament injuries","volume":"6","author":"Dahlgren","year":"2007","journal-title":"Clin Tech Equine Pract"},{"key":"10.1016\/j.jevs.2019.07.007_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0749-0739(17)30319-X","article-title":"Suspensory ligament desmitis","volume":"11","author":"Dyson","year":"1995","journal-title":"Vet Clin North Am Equine Pract"},{"key":"10.1016\/j.jevs.2019.07.007_bib9","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fphar.2018.00978","article-title":"Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses","volume":"9","author":"Kovac","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jevs.2019.07.007_bib10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.addr.2014.11.015","article-title":"Biologics for tendon repair","volume":"84","author":"Docheva","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jevs.2019.07.007_bib11","series-title":"Tendon injuries","article-title":"Gene therapy in tendon ailments","author":"Martinek","year":"2005"},{"key":"10.1016\/j.jevs.2019.07.007_bib12","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2460\/javma.232.10.1515","article-title":"Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in standardbred racehorses","volume":"232","author":"Waselau","year":"2008","journal-title":"J\u00a0Am Vet Med Assoc"},{"key":"10.1016\/j.jevs.2019.07.007_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/vr.103620","article-title":"Autologous bone marrow aspirate for treatment of superficial digital flexor tendonitis in 105 racehorses","volume":"179","author":"Russell","year":"2016","journal-title":"Vet Rec"},{"key":"10.1016\/j.jevs.2019.07.007_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3389\/fvets.2017.00205","article-title":"Extracorporeal shockwave therapy increases growth factor release from equine platelet-rich plasma in\u00a0vitro","volume":"4","author":"Seabaugh","year":"2017","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jevs.2019.07.007_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jevs.2014.12.011","article-title":"Clinical evaluation of intralesional injection of platelet-rich plasma for the treatment of proximal suspensory ligament desmitis in horses","volume":"35","author":"Romagnoli","year":"2015","journal-title":"J\u00a0Equine Vet Sci"},{"key":"10.1016\/j.jevs.2019.07.007_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fvets.2015.00049","article-title":"Tenogenically induced allogenic mesenchymal stem cells for the treatment of proximal suspensory ligament desmitis in a horse","volume":"2","author":"Vandenberghe","year":"2015","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jevs.2019.07.007_bib17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3109\/03008207.2013.787418","article-title":"Cellular and molecular factors in flexors in flexor tendon repair and adhesion: a histological and gene expression analysis","volume":"54","author":"Juneja","year":"2013","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jevs.2019.07.007_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/03008207.2012.734879","article-title":"Immunolocalization of collagens (I and III) and cartilage oligomeric matrix protein in the normal and injured equine superficial digital flexor tendon","volume":"54","author":"Sodersten","year":"2013","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jevs.2019.07.007_bib19","first-page":"181","article-title":"Biology of tendon injury: healing, modelling and remodelling","volume":"6","author":"Sharma","year":"2006","journal-title":"J\u00a0Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.jevs.2019.07.007_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bdrc.21041","article-title":"Tendon and ligament regeneration and repair: clinical relevance and development paradigm","volume":"99","author":"Yang","year":"2013","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.jevs.2019.07.007_bib21","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1109\/TUFFC.2018.2858546","article-title":"Integrated histotripsy and bubble coalescence transducer for rapid tissue ablation","volume":"65","author":"Shi","year":"2018","journal-title":"IEEE Trans Ultrason Ferroelectr Freq Control"},{"key":"10.1016\/j.jevs.2019.07.007_bib22","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.2147\/OTT.S176744","article-title":"Low-frequency ultrasound enhances chemotherapy sensitivity and induces autophagy in PTX-resistant PC-3 cells via the endoplasmic reticulum stress-mediated P13K\/Akt\/mTOT signaling pathway","volume":"11","author":"Wu","year":"2018","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.jevs.2019.07.007_bib23","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00262-017-2019-6","article-title":"Endoplasmic reticulum stress regulates tumor growth and anti-tumor immunity: a promising opportunity for cancer immunotherapy","volume":"66","author":"Mohamed","year":"2017","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.jevs.2019.07.007_bib24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1124\/mol.116.105171","article-title":"Modulation of autophagy by calcium signalosome in human disease","volume":"90","author":"Filippi-Chiela","year":"2016","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jevs.2019.07.007_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/MAJ.0b013e31821f978d","article-title":"Molecular machinery of autophagy and its implication in cancer","volume":"343","author":"Li","year":"2012","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jevs.2019.07.007_bib26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bcp.2017.11.021","article-title":"Modulating autophagy in cancer therapy: advancements and challenges for cancer cell death sensitization","volume":"147","author":"Bhat","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jevs.2019.07.007_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/SPV.0000000000000455","article-title":"Correlation between autophagy and collagen deposition in patients with pelvic organ prolapse","volume":"24","author":"Zeng","year":"2018","journal-title":"Female Pelvic Med Reconstr Surg"},{"key":"10.1016\/j.jevs.2019.07.007_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10059-013-0140-8","article-title":"Autophagy: a critical regulator of cellular metabolism and homeostasis","volume":"36","author":"Ryter","year":"2013","journal-title":"Mol Cells"},{"key":"10.1016\/j.jevs.2019.07.007_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.euje.2004.02.001","article-title":"Microbubbles and ultrasound: from diagnosis to therapy","volume":"5","author":"Dijkmans","year":"2004","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.jevs.2019.07.007_bib30","first-page":"3220","article-title":"Evaluation of deep thermal rehabilitation system using resonant cavity applicator during knee experiments","volume":"2018","author":"Shindo","year":"2018","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.jevs.2019.07.007_bib31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ultras.2009.10.002","article-title":"Cavitation microstreaming and stress fields created by microbubbles","volume":"50","author":"Collis","year":"2010","journal-title":"Ultrasonics"},{"key":"10.1016\/j.jevs.2019.07.007_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ipej.2018.10.002","article-title":"Venoplasty of a chronic venous occlusion with \u201cdiathermy\u201d for cardiac device lead placement","volume":"19","author":"Gul","year":"2018","journal-title":"Indian Pacing Electrophysiol J"},{"key":"10.1016\/j.jevs.2019.07.007_bib33","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1002\/jps.23971","article-title":"Exploitation of acoustic cavitation-induced microstreaming to enhance molecular transport","volume":"103","author":"Bhatnagar","year":"2014","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.jevs.2019.07.007_bib34","first-page":"208","article-title":"Acoustic streaming in a soft tissue microenvironment","author":"El Ghamrawy","year":"2018","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.jevs.2019.07.007_bib35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/000164700317381162","article-title":"In\u00a0vivo investigation of ECRB tendons with microdialysis technique \u2013 no signs of inflammation but high amounts of glutamate in tennis elbow","volume":"71","author":"Alfredson","year":"2000","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.jevs.2019.07.007_bib36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/bjsm.2009.058578","article-title":"In search of the tendon holy grail: predictable clinical outcomes","volume":"43","author":"Cook","year":"2009","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jevs.2019.07.007_bib37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/03008200600809893","article-title":"Expression, content, and localization of insulin-like growth factor I in human achilles tendon","volume":"47","author":"Olesen","year":"2006","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jevs.2019.07.007_bib38","doi-asserted-by":"crossref","first-page":"E257","DOI":"10.1152\/ajpendo.00609.2009","article-title":"Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle","volume":"298","author":"Holm","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jevs.2019.07.007_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0838.2006.00522.x","article-title":"Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis","volume":"17","author":"Langberg","year":"2007","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.jevs.2019.07.007_bib40","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1152\/japplphysiol.00291.2009","article-title":"Mechanical properties and collagen cross- linking of the patellar tendon in old and young men","volume":"107","author":"Coupp\u00e9","year":"2009","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.jevs.2019.07.007_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1938640009355191","article-title":"Achilles tendon rupture: a review of etiology, population, anatomy, risk factors, and injury prevention","volume":"3","author":"Hess","year":"2010","journal-title":"Foot Ankle Spec"},{"key":"10.1016\/j.jevs.2019.07.007_bib42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00002281-200103000-00009","article-title":"Achilles tendon injuries","volume":"13","author":"Ja\u00a8rvinen","year":"2001","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.jevs.2019.07.007_bib43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/art.22426","article-title":"Tenocyte responses to mechanical loading in\u00a0vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats","volume":"56","author":"Scott","year":"2007","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.jevs.2019.07.007_bib44","doi-asserted-by":"crossref","first-page":"79S","DOI":"10.1016\/j.jse.2004.09.020","article-title":"Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse model","volume":"14","author":"Perry","year":"2005","journal-title":"J\u00a0Shoulder Elbow Surg"},{"key":"10.1016\/j.jevs.2019.07.007_bib45","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1114\/1.1509765","article-title":"Rotator cuff tendinosis in an animal model: role of extrinsic and overuse factors","volume":"30","author":"Soslowsky","year":"2002","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.jevs.2019.07.007_bib46","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1058-2746(96)80070-X","article-title":"Development and use of an animal model for investigations on rotator cuff disease","volume":"5","author":"Soslowsky","year":"1996","journal-title":"J\u00a0Shoulder Elbow Surg"},{"key":"10.1016\/j.jevs.2019.07.007_bib47","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jor.20546","article-title":"Histological analysis of Achilles tendons in an overuse rat model","volume":"26","author":"Glazebrook","year":"2008","journal-title":"J\u00a0Orthop Res"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080619303818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080619303818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:46:06Z","timestamp":1760031966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0737080619303818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":47,"alternative-id":["S0737080619303818"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2019.07.007","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of Noninvasive Low-Frequency Ultrasound as a Means of Treating Injuries to Suspensory Ligaments in Horses: A Research Paper","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2019.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}