{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:16:24Z","timestamp":1787318184870,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001003","name":"Birmingham Racing Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.jevs.2019.102797","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T11:20:17Z","timestamp":1569324017000},"page":"102797","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Pharmacodynamic Effects of Pioglitazone on High Molecular Weight Adiponectin Concentrations and Insulin Response After Oral Sugar in Equids"],"prefix":"10.1016","volume":"82","author":[{"given":"Rebecca M.","family":"Legere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Judd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne A.","family":"Wooldridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jevs.2019.102797_bib1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/evj.12031","article-title":"Plasma concentrations of inflammatory markers in previously laminitic ponies","volume":"45","author":"Wray","year":"2013","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/evj.12606","article-title":"Prospective cohort study evaluating risk factors for the development of pasture-associated laminitis in the United Kingdom","volume":"49","author":"Menzies-Gow","year":"2017","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib3","first-page":"1114","article-title":"Factors associated with leptin and adiponectin concentration in a large across breed cohort of horses and ponies","volume":"28","author":"Schultz","year":"2014","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.jevs.2019.102797_bib4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/evj.12434","article-title":"Effect of increased adiposity on insulin sensitivity and adipokine concentrations in horses and ponies fed a high fat diet, with or without a once daily high glycaemic meal","volume":"48","author":"Bamford","year":"2016","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/evj.12963","article-title":"Association between hyperinsulinaemia and laminitis severity at the time of pituitary pars intermedia dysfunction diagnosis","volume":"51","author":"Tadros","year":"2019","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib6","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/jvim.15419","article-title":"Phenotypic, hormonal, and clinical characteristics of equine endocrinopathic laminitis","volume":"33","author":"de Laat","year":"2019","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.jevs.2019.102797_bib7","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/jvim.15497","article-title":"Incidence and risk factors for recurrence of endocrinopathic laminitis in horses","volume":"33","author":"de Laat","year":"2019","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.jevs.2019.102797_bib8","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/evj.12450","article-title":"Lamellar pathology in horses with pituitary pars intermedia dysfunction","volume":"48","author":"Karikoski","year":"2016","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2746\/0425164044877288","article-title":"Serum insulin concentrations in horses with equine Cushing\u2019s syndrome: response to a cortisol inhibitor and prognostic value","volume":"36","author":"McGowan","year":"2004","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2460\/ajvr.70.5.665","article-title":"Pharmacokinetics and bioavailability of metformin in horses","volume":"70","author":"Hustace","year":"2009","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jevs.2019.102797_bib11","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2460\/ajvr.71.10.1201","article-title":"Pharmacokinetics of metformin after enteral administration in insulin-resistant ponies","volume":"71","author":"Tinworth","year":"2010","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jevs.2019.102797_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tvjl.2011.01.015","article-title":"The effect of oral metformin on insulin sensitivity in insulin-resistant ponies","volume":"191","author":"Tinworth","year":"2012","journal-title":"Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF03345545","article-title":"Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels","volume":"29","author":"Otto","year":"2006","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.jevs.2019.102797_bib14","doi-asserted-by":"crossref","first-page":"E42","DOI":"10.1152\/ajpendo.00240.2005","article-title":"Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression","volume":"290","author":"Rasouli","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jevs.2019.102797_bib15","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1365-2265.2006.02658.x","article-title":"Effects of pioglitazone and metformin on plasma adiponectin in newly detected type 2 diabetes mellitus","volume":"65","author":"Sharma","year":"2006","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jevs.2019.102797_bib16","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.2337\/dc07-0308","article-title":"Pioglitazone rapidly increases serum adiponectin levels in men with normal glucose tolerance","volume":"30","author":"Ikeda","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jevs.2019.102797_bib17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2885.2010.01217.x","article-title":"Pharmacokinetics of pioglitazone after multiple oral dose administration in horses","volume":"34","author":"Wearn","year":"2011","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.jevs.2019.102797_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1939-1676.2011.0681.x","article-title":"Effects of the insulin-sensitizing drug pioglitazone and lipopolysaccharide administration on insulin sensitivity in horses","volume":"25","author":"Suagee","year":"2011","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.jevs.2019.102797_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.2042-3306.1983.tb01826.x","article-title":"Relationship between condition score, physical measurements and body fat percentage in mares","volume":"15","author":"Henneke","year":"1983","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tvjl.2008.02.029","article-title":"Apparent adiposity assessed by standardised scoring systems and morphometric measurements in horses and ponies","volume":"179","author":"Carter","year":"2009","journal-title":"Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib21","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.2460\/ajvr.73.8.1230","article-title":"Evaluation of high-molecular weight adiponectin in horses","volume":"73","author":"Wooldridge","year":"2012","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jevs.2019.102797_bib22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jevs.2013.09.006","article-title":"Assessment of insulin and glucose dynamics by using an oral sugar test in horses","volume":"34","author":"Schuver","year":"2014","journal-title":"J\u00a0Equine Vet Sci"},{"key":"10.1016\/j.jevs.2019.102797_bib23","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1939-1676.2010.0481.x","article-title":"Evaluation of a veterinary glucometer for use in horses","volume":"24","author":"Hackett","year":"2010","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.jevs.2019.102797_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/evj.12703","article-title":"The diagnosis of equine insulin dysregulation","volume":"49","author":"Bertin","year":"2017","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/evj.12169","article-title":"Insulin dysregulation","volume":"46","author":"Frank","year":"2014","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib26","doi-asserted-by":"crossref","first-page":"e0203655","DOI":"10.1371\/journal.pone.0203655","article-title":"The sodium-glucose co-transporter 2 inhibitor velagliflozin reduces hyperinsulinemia and prevents laminitis in insulin-dysregulated ponies","volume":"13","author":"Meier","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.jevs.2019.102797_bib27","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.2042-3306.2010.00111.x","article-title":"Histopathology of insulin-induced laminitis in ponies","volume":"42","author":"Asplin","year":"2010","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib28","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/evj.12413","article-title":"Comparison of the in-feed glucose test and the oral sugar test","volume":"48","author":"Smith","year":"2016","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2019.102797_bib29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/jvim.15423","article-title":"ECEIM consensus statement on equine metabolic syndrome","volume":"33","author":"Durham","year":"2019","journal-title":"J\u00a0Vet Intern Med"},{"key":"10.1016\/j.jevs.2019.102797_bib30","article-title":"Safety data and withdrawal of hepatotoxic drugs","author":"Babai","year":"2018","journal-title":"Therapie"},{"issue":"Suppl 8A","key":"10.1016\/j.jevs.2019.102797_bib31","doi-asserted-by":"crossref","first-page":"42S","DOI":"10.1016\/j.amjmed.2003.09.005","article-title":"Effect of thiazolidinediones on body weight in patients with diabetes mellitus","volume":"115","author":"Fonseca","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.jevs.2019.102797_bib32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2885.1982.tb00439.x","article-title":"Xylazine hydrochloride-induced hyperglycemia and hypoinsulinemia in thoroughbred horses","volume":"5","author":"Thurmon","year":"1982","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.jevs.2019.102797_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/jvp.12139","article-title":"Pharmacokinetic and pharmacodynamic analysis comparing diverse effects of detomidine, medetomidine, and dexmedetomidine in the horse: a population analysis","volume":"38","author":"Grimsrud","year":"2015","journal-title":"J\u00a0Vet Pharmacol Ther"},{"key":"10.1016\/j.jevs.2019.102797_bib34","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.1152\/ajpendo.00362.2015","article-title":"Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulation","volume":"310","author":"de Laat","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jevs.2019.102797_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.domaniend.2011.05.004","article-title":"The prevalence of endocrinopathic laminitis among horses presented for laminitis at a first-opinion\/referral equine hospital","volume":"41","author":"Karikoski","year":"2011","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.jevs.2019.102797_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.domaniend.2017.10.008","article-title":"The oral glucose test predicts laminitis risk in ponies fed a diet high in nonstructural carbohydrates","volume":"63","author":"Meier","year":"2018","journal-title":"Domest Anim Endocrinol"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080619305465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080619305465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:44:50Z","timestamp":1760031890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0737080619305465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":36,"alternative-id":["S0737080619305465"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2019.102797","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacodynamic Effects of Pioglitazone on High Molecular Weight Adiponectin Concentrations and Insulin Response After Oral Sugar in Equids","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2019.102797","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102797"}}