{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:41:13Z","timestamp":1789749673535,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jevs.2023.104937","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T05:07:06Z","timestamp":1696828026000},"page":"104937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Investigation of Serum Markers of Hepatic Fibrosis in Equids"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-8756","authenticated-orcid":false,"given":"Julie F.N.","family":"Potier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy E.","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raakesh","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-2304","authenticated-orcid":false,"given":"William","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jevs.2023.104937_bib0001","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1439-0396.2007.00798.x","article-title":"Hepatic diseases in horses","volume":"92","author":"Bergero","year":"2008","journal-title":"J Anim Physiol Anim Nutr (Berl)"},{"issue":"6","key":"10.1016\/j.jevs.2023.104937_bib0002","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2746\/042516403775467207","article-title":"Equine hepatic disease: the effect of patient- and case-specific variables on risk and prognosis","volume":"35","author":"Smith","year":"2003","journal-title":"Equine Vet J"},{"issue":"6","key":"10.1016\/j.jevs.2023.104937_bib0003","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2746\/042516403775467289","article-title":"Liver disease: contributions to diagnostic and prognostic aids","volume":"35","author":"Byars","year":"2003","journal-title":"Equine Vet J"},{"issue":"6","key":"10.1016\/j.jevs.2023.104937_bib0004","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2746\/042516403775467216","article-title":"An evaluation of diagnostic data in comparison to the results of liver biopsies in mature horses","volume":"35","author":"Durham","year":"2003","journal-title":"Equine Vet J"},{"issue":"6","key":"10.1016\/j.jevs.2023.104937_bib0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2746\/042516403775467171","article-title":"Development and application of a scoring system for prognostic evaluation of equine liver biopsies","volume":"35","author":"Durham","year":"2003","journal-title":"Equine Vet J"},{"issue":"6","key":"10.1016\/j.jevs.2023.104937_bib0006","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2746\/042516403775467324","article-title":"Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease","volume":"35","author":"Durham","year":"2003","journal-title":"Equine Vet J"},{"issue":"3","key":"10.1016\/j.jevs.2023.104937_bib0007","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2460\/javma.1989.194.03.405","article-title":"Cholelithiasis in horses: ten cases (1982-1986)","volume":"194","author":"Johnston","year":"1989","journal-title":"J Am Vet Med Assoc"},{"issue":"4","key":"10.1016\/j.jevs.2023.104937_bib0008","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2746\/042516400777032156","article-title":"Medical treatment of cholangiohepatitis and cholelithiasis in mature horses: 9 cases (1991-1998)","volume":"32","author":"Peek","year":"2000","journal-title":"Equine Vet J"},{"issue":"2","key":"10.1016\/j.jevs.2023.104937_bib0009","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.2042-3306.1996.tb01607.x","article-title":"Clinical and pathological studies in horses with hepatic disease","volume":"28","author":"West","year":"1996","journal-title":"Equine Vet J"},{"issue":"2","key":"10.1016\/j.jevs.2023.104937_bib0010","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0091-0279(73)50037-6","article-title":"Equine hepatic insufficiency","volume":"3","author":"Tennant","year":"1973","journal-title":"Vet Clin North Am"},{"issue":"1","key":"10.1016\/j.jevs.2023.104937_bib0011","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1939-1676.2007.0006.x","article-title":"Coagulation abnormalities and complications after percutaneous liver biopsy in horses","volume":"22","author":"Johns","year":"2008","journal-title":"J Vet Intern Med"},{"issue":"4","key":"10.1016\/j.jevs.2023.104937_bib0012","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep.21496","article-title":"The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD","volume":"45","author":"Angulo","year":"2007","journal-title":"Hepatology"},{"issue":"39","key":"10.1016\/j.jevs.2023.104937_bib0013","doi-asserted-by":"crossref","first-page":"11077","DOI":"10.3748\/wjg.v21.i39.11077","article-title":"Liver fibrosis in non-alcoholic fatty liver disease - diagnostic challenge with prognostic significance","volume":"21","author":"St\u00e5l","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"41","key":"10.1016\/j.jevs.2023.104937_bib0014","doi-asserted-by":"crossref","first-page":"11567","DOI":"10.3748\/wjg.v21.i41.11567","article-title":"Non-invasive diagnosis of liver fibrosis and cirrhosis","volume":"21","author":"Lurie","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"24","key":"10.1016\/j.jevs.2023.104937_bib0015","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.3748\/wjg.v21.i24.7427","article-title":"Liver fibrosis markers of nonalcoholic steatohepatitis","volume":"21","author":"Enomoto","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.jevs.2023.104937_bib0016","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2004.08.052","article-title":"Serum markers detect the presence of liver fibrosis: a cohort study","volume":"127","author":"Rosenberg","year":"2004","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jevs.2023.104937_bib0017","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/hep.21984","article-title":"Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European Liver Fibrosis Panel and exploring simple markers","volume":"47","author":"Guha","year":"2008","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.jevs.2023.104937_bib0018","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/gutjnl-2018-317593","article-title":"Advances in non-invasive assessment of hepatic fibrosis","volume":"69","author":"Loomba","year":"2020","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.jevs.2023.104937_bib0019","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jhep.2013.03.016","article-title":"The enhanced liver fibrosis (ELF) score: normal values, influence factors and proposed cut-off values","volume":"59","author":"Lichtinghagen","year":"2013","journal-title":"J Hepatol"},{"issue":"9","key":"10.1016\/j.jevs.2023.104937_bib0020","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1751-0813.2006.00025.x","article-title":"Serum and plasma cardiac troponin I concentrations in clinically normal Thoroughbreds in training in Australia","volume":"84","author":"Begg","year":"2006","journal-title":"Aust Vet J"},{"issue":"1","key":"10.1016\/j.jevs.2023.104937_bib0021","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1746-6148-10-125","article-title":"Rate of manual leukocyte differentials in dog, cat and horse blood samples using ADVIA 120 cytograms","volume":"10","author":"Stirn","year":"2014","journal-title":"BMC Vet Res"},{"issue":"6","key":"10.1016\/j.jevs.2023.104937_bib0022","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00580-011-1284-6","article-title":"Evaluation of an equine-optimized enzyme-linked immunosorbent assay for serum insulin measurement and stability study of equine serum insulin","volume":"21","author":"\u00d6berg","year":"2012","journal-title":"Compar Clin Pathol"},{"key":"10.1016\/j.jevs.2023.104937_bib0023","series-title":"Verification of the analytical performance of the ADVIA Centaur Enhanced Liver Fibrosis test","author":"Selby","year":"2018"},{"issue":"4","key":"10.1016\/j.jevs.2023.104937_bib0024","doi-asserted-by":"crossref","first-page":"e92772","DOI":"10.1371\/journal.pone.0092772","article-title":"The performance of enhanced liver fibrosis (ELF) test for the staging of liver fibrosis: a meta-analysis","volume":"9","author":"Xie","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jevs.2023.104937_bib0025","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1111\/jgh.15482","article-title":"Systematic review: accuracy of the enhanced liver fibrosis test for diagnosing advanced liver fibrosis and cirrhosis","volume":"36","author":"Sharma","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.jevs.2023.104937_bib0026","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jhep.2020.03.036","article-title":"Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis","volume":"73","author":"Vali","year":"2020","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.jevs.2023.104937_bib0027","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0014-4827(83)90458-5","article-title":"Endothelial cells are a site of uptake and degradation of hyaluronic acid in the liver","volume":"144","author":"Eriksson","year":"1983","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.jevs.2023.104937_bib0028","first-page":"79","article-title":"Removal of hyaluronic acid from the circulation in rheumatoid disease and primary biliary cirrhosis","volume":"107","author":"Fraser","year":"1986","journal-title":"J Lab Clin Med"},{"issue":"1","key":"10.1016\/j.jevs.2023.104937_bib0029","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0168-8278(95)80255-X","article-title":"Serum hyaluronan as a marker of liver fibrosis in chronic viral hepatitis C: effect of alpha-interferon therapy","volume":"22","author":"Gu\u00e9chot","year":"1995","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.jevs.2023.104937_bib0030","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1515\/pjvs-2016-0045","article-title":"Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis","volume":"19","author":"Gli\u0144ska-Suchocka","year":"2016","journal-title":"Pol J Vet Sci"},{"issue":"12","key":"10.1016\/j.jevs.2023.104937_bib0031","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1111\/liv.14225","article-title":"Plasma N-terminal propeptide of type III procollagen accurately predicts liver fibrosis severity in children with non-alcoholic fatty liver disease","volume":"39","author":"Mosca","year":"2019","journal-title":"Liver Int"},{"issue":"4","key":"10.1016\/j.jevs.2023.104937_bib0032","doi-asserted-by":"crossref","first-page":"e00360","DOI":"10.1042\/BSR20160107","article-title":"Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis","volume":"36","author":"Robert","year":"2016","journal-title":"Biosci Rep"},{"issue":"5","key":"10.1016\/j.jevs.2023.104937_bib0033","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s10495-013-0827-5","article-title":"Hepatic apoptosis can modulate liver fibrosis through TIMP1 pathway","volume":"18","author":"Wang","year":"2013","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.jevs.2023.104937_bib0034","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/j.2040-4603.2013.tb00529.x","article-title":"Hepatic stellate cells and liver fibrosis","volume":"3","author":"Puche","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jevs.2023.104937_bib0035","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.matbio.2017.11.011","article-title":"Matrix metalloproteinase functions in hepatic injury and fibrosis","volume":"68-69","author":"Roderfeld","year":"2018","journal-title":"Matrix Biol"},{"issue":"5","key":"10.1016\/j.jevs.2023.104937_bib0036","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies","volume":"46","author":"Hemmann","year":"2007","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.jevs.2023.104937_bib0037","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1751-0813.2000.tb11791.x","article-title":"Changes in liver copper concentration of thoroughbred foals from birth to 160 days of age and the effect of prenatal copper supplementation of their dams","volume":"78","author":"Gee","year":"2000","journal-title":"Aust Vet J"},{"issue":"5","key":"10.1016\/j.jevs.2023.104937_bib0038","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1740-8261.2011.01846.x","article-title":"Starry sky hepatic ultrasonographic pattern in horses","volume":"52","author":"Carlson","year":"2011","journal-title":"Vet Radiol Ultrasound"},{"issue":"7","key":"10.1016\/j.jevs.2023.104937_bib0039","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1053\/j.gastro.2005.03.084","article-title":"Sampling variability of liver biopsy in nonalcoholic fatty liver disease","volume":"128","author":"Ratziu","year":"2005","journal-title":"Gastroenterology"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080623007530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080623007530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:56:03Z","timestamp":1760032563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0737080623007530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":39,"alternative-id":["S0737080623007530"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2023.104937","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of Serum Markers of Hepatic Fibrosis in Equids","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2023.104937","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104937"}}