{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:54:15Z","timestamp":1791406455768,"version":"4.3.3"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jevs.2026.105778","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:21:08Z","timestamp":1767831668000},"page":"105778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effects of intrauterine ozone insufflation in eleven subfertile mares: a case series"],"prefix":"10.1016","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-1749","authenticated-orcid":false,"given":"R.","family":"Moroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Fanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Maltinti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0483-6849","authenticated-orcid":false,"given":"M.","family":"Orefice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3379-2003","authenticated-orcid":false,"given":"A.","family":"Rota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Camillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Melanie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cantile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Miragliotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pirone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5341-6470","authenticated-orcid":false,"given":"G.","family":"Lazzarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Passamonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Marmorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Panzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0001","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0093-691X(99)00143-0","article-title":"Uterine clearance and resistance to persistent endometritis in the mare","volume":"52","author":"Troedsson","year":"1999","journal-title":"Theriogenology"},{"issue":"Suppl 2","key":"10.1016\/j.jevs.2026.105778_bib0002","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1439-0531.2010.01634.x","article-title":"Advances in the diagnosis and treatment of chronic infectious and post-mating-induced endometritis in the mare","volume":"45","author":"LeBlanc","year":"2010","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.jevs.2026.105778_bib0003","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cveq.2006.07.003","article-title":"Breeding-induced endometritis in mare","volume":"22","author":"Troedsson","year":"2006","journal-title":"Vet Clin North Am Equine Pr"},{"issue":"5","key":"10.1016\/j.jevs.2026.105778_bib0004","doi-asserted-by":"crossref","first-page":"R95","DOI":"10.1530\/REP-19-0478","article-title":"Equine endometritis: a review of challenges and new approaches","volume":"160","author":"Morris","year":"2020","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.jevs.2026.105778_bib0005","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3390\/ijms21041432","article-title":"Persistent breeding-induced endometritis in mares \u2013 A multifaceted challenge: from clinical aspects to immunopathogenesis and pathobiology","volume":"21","author":"Canisso","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0006","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/REP-12-0452","article-title":"Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis","volume":"145","author":"Woodward","year":"2013","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0007","doi-asserted-by":"crossref","first-page":"56","DOI":"10.21836\/PEM20080112","article-title":"Persistent breeding-induced endometritis","volume":"24","author":"Troedsson","year":"2008","journal-title":"Pferdeheilkunde"},{"issue":"Suppl 3","key":"10.1016\/j.jevs.2026.105778_bib0008","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/rda.13013","article-title":"Inflammation and fertility in the mare","volume":"52","author":"Christoffersen","year":"2017","journal-title":"Reprod Domest Anim"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0009","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cveq.2016.08.004","article-title":"Endometritis: managing persistent post-breeding endometritis","volume":"32","author":"Canisso","year":"2016","journal-title":"Vet Clin North Am Equine Pr"},{"key":"10.1016\/j.jevs.2026.105778_bib0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1439-0531.2009.01485.x","article-title":"Clinical and subclinical endometritis in the mare: both threats to fertility","volume":"44","author":"LeBlanc","year":"2009","journal-title":"Reprod Domest Anim"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0011","first-page":"723","article-title":"Equine endometrial biopsy","volume":"2","author":"Kenney","year":"1986","journal-title":"Curr Ther Theriogenol"},{"issue":"7","key":"10.1016\/j.jevs.2026.105778_bib0012","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.theriogenology.2010.12.002","article-title":"Comparison of three diagnostic methods to identify subclinical endometritis in mares","volume":"75","author":"Overbeck","year":"2011","journal-title":"Theriogenology"},{"issue":"2","key":"10.1016\/j.jevs.2026.105778_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jevs.2026.105778_bib0014","first-page":"363","article-title":"A practical method for recognizing mares susceptible to post-breeding endometritis","volume":"49","author":"Brinsko","year":"2003","journal-title":"Reprod AAEP Proc"},{"key":"10.1016\/j.jevs.2026.105778_bib0015","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.2460\/ajvr.1998.59.10.1209","article-title":"Morphometric analysis of endometrial periglandular fibrosis in mares","volume":"59","author":"Evans","year":"1998","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jevs.2026.105778_bib0016","unstructured":"Oddsd\u00f3ttir C. Development of endometrial fibrosis in the mare: factors involved in tissue remodelling and collagen deposition. 2007."},{"key":"10.1016\/j.jevs.2026.105778_bib0017","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.theriogenology.2019.11.014","article-title":"Uterine responses and equine chorionic gonadotropin concentrations after two intrauterine infusions with kerosene post early fetal loss in mares","volume":"147","author":"Podico","year":"2020","journal-title":"Theriogenology"},{"key":"10.1016\/j.jevs.2026.105778_bib0018","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.theriogenology.2024.08.031","article-title":"Collagen and collagenases in mare's endometrium with endometrosis","volume":"230","author":"Centeno","year":"2024","journal-title":"Theriogenology"},{"key":"10.1016\/j.jevs.2026.105778_bib0019","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9975(98)80051-0","article-title":"Incidence and morphology of endometrial angiopathies in mares in relationship to age and parity","volume":"119","author":"Gr\u00fcninger","year":"1998","journal-title":"J Comp Pathol"},{"issue":"2","key":"10.1016\/j.jevs.2026.105778_bib0020","doi-asserted-by":"crossref","first-page":"171\u2011177","DOI":"10.4142\/jvs.2012.13.2.171","article-title":"The role of inflammation and matrix metalloproteinases in equine endometriosis","volume":"13","author":"Aresu","year":"2012","journal-title":"J Vet Sci"},{"issue":"2","key":"10.1016\/j.jevs.2026.105778_bib0021","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.2042-3306.1996.tb01600.x","article-title":"Lymphocyte subsets in the endometrium of genitally normal mares and mares susceptible to endometritis","volume":"28","author":"Watson","year":"1996","journal-title":"Equine Vet J"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0022","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.2042-3306.1998.tb04092.x","article-title":"Endometrial macrophage populations in genitally normal mares at oestrus and dioestrus and in mares susceptible to endometritis","volume":"30","author":"Summerfield","year":"1998","journal-title":"Equine Vet J"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0023","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21836\/PEM20140101","article-title":"Lymphocyte subpopulations in the equine endometrium: a methodical approach with diagnostic implications","volume":"30","author":"Huth","year":"2014","journal-title":"Pferdeheilkunde"},{"issue":"6","key":"10.1016\/j.jevs.2026.105778_bib0024","article-title":"Immunohistochemical characterisation of immune cells in fixed equine endometrial tissue: a diagnostic relevant method","volume":"33","author":"Rudolph","year":"2017","journal-title":"Pferdeheilkunde"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0025","article-title":"Characterisation of immune cells within the equine endometrium\u2013a true challenge!","volume":"34","author":"Rudolph","year":"2018","journal-title":"Pferdeheilkunde"},{"key":"10.1016\/j.jevs.2026.105778_bib0026","article-title":"Complimentary diagnostic tools for endometrosis in biopsies of mares with clinical subfertility","volume":"48","author":"Rojas","year":"2020","journal-title":"Acta Sci Vet"},{"key":"10.1016\/j.jevs.2026.105778_bib0027","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jcpa.2019.10.113","article-title":"Immunohistochemical characterization of lymphocytic subpopulations (CD3\/CD20) in endometrium of sub-fertile mares","volume":"174","author":"Varello","year":"2019","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.jevs.2026.105778_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-015-2139-3","article-title":"Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle","volume":"16","author":"Marth","year":"2015","journal-title":"BMC Genom"},{"key":"10.1016\/j.jevs.2026.105778_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13567-016-0398-x","article-title":"Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis","volume":"47","author":"Marth","year":"2016","journal-title":"Vet Res"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0030","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1071\/RD17157","article-title":"Innate immune genes in persistent mating-induced endometritis in horses","volume":"30","author":"Marth","year":"2018","journal-title":"Reprod Fertil Dev"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0031","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/s41598-020-58109-0","article-title":"Matrix metallopeptidase expression and modulation by transforming growth factor-\u03b21 in equine endometrosis","volume":"10","author":"Sz\u00f3stek-Mioduchowska","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jevs.2026.105778_bib0032","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/evj.14080","article-title":"Endometrial expression of antimicrobial peptides as markers of subclinical endometritis in mares","volume":"56","author":"Moroni","year":"2024","journal-title":"Equine Vet J"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0033","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cveq.2016.08.002","article-title":"Endometritis: nontraditional therapies","volume":"32","author":"Scoggin","year":"2016","journal-title":"Vet Clin North Am Equine Pr"},{"issue":"4","key":"10.1016\/j.jevs.2026.105778_bib0034","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.arcmed.2005.08.006","article-title":"Scientific and medical aspects of ozone therapy: state of the art","volume":"37","author":"Bocci","year":"2006","journal-title":"Arch Med Res"},{"key":"10.1016\/j.jevs.2026.105778_bib0035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.rvsc.2021.01.018","article-title":"The main uses of ozone therapy in diseases of large animals: a review","volume":"136","author":"de Souza","year":"2021","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jevs.2026.105778_bib0036","first-page":"171","article-title":"Lavaje uterino con agua ozonizada para el tratamiento de endometritis en yeguas","volume":"12","author":"Heredia","year":"2013","journal-title":"Int J Ozone Ther"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0037","article-title":"Intrauterine infusion reduces inflammatory status and could increase embryo recovery in mares with chronic endometritis","volume":"14","author":"Cardoso Zoccal Janini","year":"2020","journal-title":"PUBVET"},{"issue":"9","key":"10.1016\/j.jevs.2026.105778_bib0038","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/rda.13958","article-title":"Endometrial angiogenesis induced by uterine insufflation with an oxygen-ozone gas mixture in mares","volume":"56","author":"Camargo Ferreira","year":"2021","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.jevs.2026.105778_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jevs.2022.103900","article-title":"Effectiveness of ozone therapy in the treatment of endometritis in mares","volume":"112","author":"\u00c1vila","year":"2022","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.jevs.2026.105778_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jevs.2023.104222","article-title":"Safety and effects of a commercial ozone foam preparation on endometrial environment and fertility of mares","volume":"121","author":"Donato","year":"2023","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.jevs.2026.105778_bib0041","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.theriogenology.2024.02.011","article-title":"In vitro effects of different ozone preparations on microorganisms responsible for endometritis in the mare","volume":"219","author":"Donato","year":"2024","journal-title":"Theriogenology"},{"key":"10.1016\/j.jevs.2026.105778_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2023.1102149","article-title":"Comparison of systemic trimethoprim-sulfadimethoxine treatment and intrauterine ozone application as possible therapies for bacterial endometritis in equine practice","volume":"10","author":"K\u00f6hne","year":"2023","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jevs.2026.105778_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.jevs.2023.104735","article-title":"Use of ozonated sunflower oil in the treatment of infectious endometritis in mares","volume":"125","author":"Oliveira","year":"2023","journal-title":"J Equine Vet Sci"},{"issue":"9","key":"10.1016\/j.jevs.2026.105778_bib0044","doi-asserted-by":"crossref","DOI":"10.1111\/rda.14718","article-title":"Does the Uterine Ozone therapy alter the transcript profile of anti- and proinflammatory genes in mares with endometritis?","volume":"59","author":"Botelho","year":"2024","journal-title":"Reprod Domest Anim"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.2042-3306.1988.tb01451.x","article-title":"Body condition scoring and weight estimation of horses","volume":"20","author":"Carroll","year":"1988","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2026.105778_bib0046","series-title":"Nutrient Requirements Of Horses: Sixth Revised Edition","year":"2007"},{"key":"10.1016\/j.jevs.2026.105778_bib0047","series-title":"Equine Breeding Management And Artificial Insemination","first-page":"133","article-title":"Uterine edema in the mare","author":"Samper","year":"2009"},{"key":"10.1016\/j.jevs.2026.105778_bib0048","series-title":"Reproductive biology of the mare: basic and applied aspects","first-page":"75","article-title":"Sexual behavior","author":"Ginther","year":"1992"},{"key":"10.1016\/j.jevs.2026.105778_bib0049","doi-asserted-by":"crossref","first-page":"1269\u20111283","DOI":"10.1016\/0093-691X(88)90007-6","article-title":"Use of a low\u2011volume uterine flush for microbiologic and cytologic examination of the mare\u2019s endometrium","volume":"29","author":"Ball","year":"1988","journal-title":"Theriogenology"},{"key":"10.1016\/j.jevs.2026.105778_bib0050","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.theriogenology.2007.04.038","article-title":"Use of a low-volume uterine flush for diagnosing endometritis in chronically infertile mares","volume":"68","author":"LeBlanc","year":"2007","journal-title":"Theriogenology"},{"issue":"4","key":"10.1016\/j.jevs.2026.105778_bib0051","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/vcp.12194","article-title":"Comparison of equine endometrial cytology samples collected with uterine swab, uterine brush, and low-volume lavage from healthy mares","volume":"43","author":"Bohn","year":"2014","journal-title":"Vet Clin Pathol"},{"issue":"8","key":"10.1016\/j.jevs.2026.105778_bib0052","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.theriogenology.2012.07.015","article-title":"Donkey jack (Equus asinus) semen cryopreservation: studies of seminal parameters, post-breeding inflammatory response, and fertility in donkey jennies","volume":"78","author":"Rota","year":"2012","journal-title":"Theriogenology"},{"key":"10.1016\/j.jevs.2026.105778_bib0053","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1756-0500-4-120","article-title":"Expression stability of putative reference genes in equine endometrial, testicular, and conceptus tissues","volume":"4","author":"Klein","year":"2011","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.jevs.2026.105778_bib0054","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2460\/javma.1978.172.03.241","article-title":"Cyclic and pathologic changes in the mare endometrium as detected by biopsy, with a note on early embryonic death","volume":"172","author":"Kenney","year":"1978","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jevs.2026.105778_bib0055","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1186\/s12917-019-2215-z","article-title":"Different expression of defensin-B gene in the endometrium of mares of different age during the breeding season","volume":"15","author":"Crociati","year":"2019","journal-title":"BMC Vet Res"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0056","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/2045-9912.215752","article-title":"Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility","volume":"7","author":"Smith","year":"2017","journal-title":"Med Gas Res"},{"issue":"11","key":"10.1016\/j.jevs.2026.105778_bib0057","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1016\/j.watres.2010.03.017","article-title":"Mechanisms of Escherichia coli inactivation by several disinfectants","volume":"44","author":"Cho","year":"2010","journal-title":"Water Res"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0058","first-page":"106","article-title":"Alteration in Escherichia coli and Streptococcus faecalis cells induced by ozone","volume":"1","author":"Zhang","year":"2016","journal-title":"J Food Sci Technol"},{"key":"10.1016\/j.jevs.2026.105778_bib0059","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejphar.2017.06.017","article-title":"Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients","volume":"811","author":"Delgado-Roche","year":"2017","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0060","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10753-020-01184-2","article-title":"Anti-inflammatory effect of ozone therapy in an experimental model of rheumatoid arthritis","volume":"43","author":"Tartari","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.jevs.2026.105778_bib0061","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-9912-1-6","article-title":"Oxygen\/ozone as a medical gas mixture: a critical evaluation of the various methods clarifies positive and negative aspects","volume":"1","author":"Bocci","year":"2011","journal-title":"Med Gas Res"},{"issue":"12","key":"10.1016\/j.jevs.2026.105778_bib0062","first-page":"546","article-title":"Case report of the treatment of two mares by uterus insufflation with an ozone-oxygen mix after positive test results for MRSA in endometrial swabs","volume":"68","author":"Kempchen","year":"2013","journal-title":"Tierarztl Umsch"},{"issue":"2","key":"10.1016\/j.jevs.2026.105778_bib0063","first-page":"103","article-title":"Ozone treatment of metritis and endometritis in Holstein cows","volume":"84","author":"\u0110uri\u010di\u0107","year":"2014","journal-title":"Vet Arh"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0064","first-page":"778","article-title":"An alternative therapy with ozone to avoid antimicrobial resistance (AMR) in uterine infections in dairy cattle","volume":"1","author":"Durrani","year":"2017","journal-title":"Biomed J Sci Tech Res"},{"issue":"SI","key":"10.1016\/j.jevs.2026.105778_bib0065","first-page":"83","article-title":"Efficacy of intrauterine ozone therapy in repeat breeder cows with subclinical uterine infection","volume":"59","author":"Mali","year":"2020","journal-title":"Haryana Vet"},{"issue":"5","key":"10.1016\/j.jevs.2026.105778_bib0066","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1007\/s11250-020-02298-3","article-title":"Intrauterine therapy with ozone reduces subclinical endometritis and improves reproductive performance in postpartum dairy cows managed in pasture-based systems","volume":"52","author":"Escand\u00f3n","year":"2020","journal-title":"Trop Anim Health Prod"},{"issue":"9","key":"10.1016\/j.jevs.2026.105778_bib0067","article-title":"Does the Uterine Ozone therapy alter the transcript profile of anti- and proinflammatory genes in mares with endometritis?","volume":"59","author":"Botelho","year":"2024","journal-title":"Reprod Domest Anim = Zuchthyg"},{"key":"10.1016\/j.jevs.2026.105778_bib0068","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.2042-3306.1991.tb02752.x","article-title":"The effect of age and parity on the development of equine chronic endometrial disease","volume":"23","author":"Ricketts","year":"1991","journal-title":"Equine Vet J"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0069","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.2042-3306.1991.tb02751.x","article-title":"Assessment of the breeding prognosis of mares using paired endometrial biopsy techniques","volume":"23","author":"Ricketts","year":"1991","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2026.105778_bib0070","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.theriogenology.2010.12.013","article-title":"Equine endometrial biopsy reviewed: observation, interpretation, and application of histopathologic data","volume":"75","author":"Snider","year":"2011","journal-title":"Theriogenology"},{"key":"10.1016\/j.jevs.2026.105778_bib0071","doi-asserted-by":"crossref","unstructured":"Westendorf J., Wobeser B., Epp T. IIB or not IIB, part 1: retrospective evaluation of Kenney-Doig categorization of equine endometrial biopsies at a veterinary diagnostic laboratory and comparison with published reports. J Vet Diagn Invest 2022 A;34(2):206\u2013214.","DOI":"10.1177\/10406387211062207"},{"key":"10.1016\/j.jevs.2026.105778_bib0072","doi-asserted-by":"crossref","unstructured":"Westendorf J., Wobeser B., Epp T. IIB or not IIB, part 2: assessing inter-rater and intra-rater repeatability of the Kenney-Doig scale in equine endometrial biopsy evaluation. J Vet Diagn Invest 2022 B;34(2):215\u2013225.","DOI":"10.1177\/10406387211062866"},{"issue":"2\u20134","key":"10.1016\/j.jevs.2026.105778_bib0073","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.anireprosci.2008.03.019","article-title":"The equine endometrosis: new insights into the pathogenesis","volume":"111","author":"Hoffmann","year":"2009","journal-title":"Anim Reprod Sci"},{"issue":"7","key":"10.1016\/j.jevs.2026.105778_bib0074","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.theriogenology.2011.06.001","article-title":"Morpho-functional studies regarding the fertility prognosis of mares suffering from equine endometrosis","volume":"76","author":"Lehmann","year":"2011","journal-title":"Theriogenology"},{"issue":"Suppl 4","key":"10.1016\/j.jevs.2026.105778_bib0075","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/rda.12397","article-title":"Physiopathologic mechanisms involved in mare endometrosis","volume":"49","author":"Rebord\u00e3o","year":"2014","journal-title":"Reprod Domest Anim"},{"issue":"11","key":"10.1016\/j.jevs.2026.105778_bib0076","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3390\/biom10111585","article-title":"Digital image analysis of picrosirius red staining: a robust method for multi-organ fibrosis quantification and characterization","volume":"10","author":"Courtoy","year":"2020","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.jevs.2026.105778_bib0077","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0143-4004(05)80005-0","article-title":"The maternal leucocyte response to the endometrial cups in horses is correlated with the developmental stages of the invasive trophoblast cells","volume":"16","author":"Gr\u00fcnig","year":"1995","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0078","doi-asserted-by":"crossref","first-page":"43","DOI":"10.21836\/PEM20180107","article-title":"Is mare endometrosis linked to oviduct fibrosis?","volume":"34","author":"Pinto-Bravo","year":"2018","journal-title":"Pferdeheilkunde"},{"issue":"6","key":"10.1016\/j.jevs.2026.105778_bib0079","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1600-0897.2010.00813.x","article-title":"The contribution of macrophages to normal and pathological pregnancies","volume":"63","author":"Nagamatsu","year":"2010","journal-title":"Am J Reprod Immunol"},{"issue":"5","key":"10.1016\/j.jevs.2026.105778_bib0080","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1600-0897.2012.01181.x","article-title":"A subset of human uterine endometrial macrophages is alternatively activated","volume":"68","author":"Jensen","year":"2012","journal-title":"Am J Reprod Immunol"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0081","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/aji.12331","article-title":"Subpopulations of macrophages within eutopic endometrium of endometriosis patients","volume":"73","author":"Takebayashi","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.jevs.2026.105778_bib0082","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6285813","article-title":"Serum and ectopic endometrium from women with endometriosis modulate macrophage M1\/M2 polarization via the Smad2\/Smad3 pathway","volume":"2018","author":"Nie","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jevs.2026.105778_bib0083","article-title":"Identification and validation of the signatures of infiltrating immune cells in the eutopic endometrium endometria of women with endometriosis","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.jevs.2026.105778_bib0084","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0602325","article-title":"The many faces of macrophage activation","volume":"73","author":"Mosser","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jevs.2026.105778_bib0086","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032333","article-title":"Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair","volume":"7","author":"Dakin","year":"2012","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.jevs.2026.105778_bib0087","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2741\/2692","article-title":"Macrophage activation and polarization","volume":"13","author":"Martinez","year":"2008","journal-title":"Front Biosci"},{"issue":"12","key":"10.1016\/j.jevs.2026.105778_bib0088","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0089","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"issue":"18","key":"10.1016\/j.jevs.2026.105778_bib0090","doi-asserted-by":"crossref","first-page":"9946","DOI":"10.3390\/ijms22189946","article-title":"Ozone as modulator of resorption and inflammatory response in extruded nucleus pulposus herniation. Revising concepts","volume":"22","author":"Erario","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.jevs.2026.105778_bib0091","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jevs.2026.105778_bib0092","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0093","doi-asserted-by":"crossref","first-page":"26\u201135","DOI":"10.1016\/j.molimm.2014.10.021","article-title":"Synergistic effect of pro\u2011inflammatory tnf\u03b1 and IL\u201117 in periostin mediated collagen deposition: potential role in liver fibrosis","volume":"64","author":"Amara","year":"2015","journal-title":"Mol Immunol"},{"issue":"5","key":"10.1016\/j.jevs.2026.105778_bib0094","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1165\/rcmb.2015-0020TR","article-title":"Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis","volume":"53","author":"Craig","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jevs.2026.105778_bib0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.reprotox.2015.08.001","article-title":"Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A","volume":"58","author":"Kendziorski","year":"2015","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jevs.2026.105778_bib0096","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.peptides.2016.01.004","article-title":"Cardiorenal fibrosis and dysfunction in aging: imbalance in mediators and regulators of collagen","volume":"76","author":"Sangaralingham","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.jevs.2026.105778_bib0097","doi-asserted-by":"crossref","first-page":"66\u201169","DOI":"10.1111\/rda.13258","article-title":"Elastase inhibition affects collagen transcription and prostaglandin secretion in mare endometrium during the estrous cycle","volume":"53","author":"Amaral","year":"2018","journal-title":"Reprod Dom Anim"},{"key":"10.1016\/j.jevs.2026.105778_bib0098","article-title":"Matrix metalloproteinase 2 (MMP-2) and tissue transglutaminase (TG 2) are expressed in periglandular fibrosis in horse mares with endometrosis","author":"Walter","year":"2005","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jevs.2026.105778_bib0099","first-page":"189","article-title":"Ultrasonographic appearance and the pattern of uterine edema to time ovulation in mares","volume":"43","author":"Samper","year":"1997","journal-title":"Proc Am Assoc Equine Pr"},{"issue":"4","key":"10.1016\/j.jevs.2026.105778_bib0100","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1439-0531.2002.00375.x","article-title":"An overview of low dose insemination in the mare","volume":"37","author":"Morris","year":"2002","journal-title":"Reprod Domest Anim"},{"issue":"Suppl","key":"10.1016\/j.jevs.2026.105778_bib0101","first-page":"61","article-title":"Equine artificial insemination in French National Studs","volume":"6","author":"Vidament","year":"2000","journal-title":"Reprod Domest Anim"},{"issue":"3\u20134","key":"10.1016\/j.jevs.2026.105778_bib0102","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0378-4320(01)00156-7","article-title":"The equine frozen semen industry","volume":"68","author":"Loomis","year":"2001","journal-title":"Anim Reprod Sci"},{"issue":"1","key":"10.1016\/j.jevs.2026.105778_bib0103","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1439-0531.2011.01805.x","article-title":"Effect of preventive intrauterine ozone application on reproductive efficiency in Holstein cows","volume":"47","author":"Djuricic","year":"2012","journal-title":"Reprod Domest Anim"},{"issue":"3\u20134","key":"10.1016\/j.jevs.2026.105778_bib0104","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.anireprosci.2012.08.023","article-title":"Intrauterine ozone treatment of retained fetal membrane in Simmental cows","volume":"134","author":"Djuricic","year":"2012","journal-title":"Anim Reprod Sci"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626000146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626000146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:24:30Z","timestamp":1791404670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0737080626000146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":104,"alternative-id":["S0737080626000146"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2026.105778","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of intrauterine ozone insufflation in eleven subfertile mares: a case series","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2026.105778","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105778"}}