{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:33:47Z","timestamp":1777275227885,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020902","name":"Ministerul Agriculturii \u0219i Dezvoltarii Rurale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020902","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017600","name":"National Research Institute of Animal Production","doi-asserted-by":"publisher","award":["03-18-26-09"],"award-info":[{"award-number":["03-18-26-09"]}],"id":[{"id":"10.13039\/100017600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jevs.2026.105877","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:43:00Z","timestamp":1775230980000},"page":"105877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["DMRT3 gene variations in horse breeds selected for gaited movement \u2013 established research and novel findings"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-0495","authenticated-orcid":false,"given":"Katarzyna","family":"Ropka-Molik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-9402","authenticated-orcid":false,"given":"Adrianna D.","family":"Musia\u0142","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8483-252X","authenticated-orcid":false,"given":"Anna","family":"Majtyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7127-0265","authenticated-orcid":false,"given":"Agnieszka","family":"Bieniek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9325-7889","authenticated-orcid":false,"given":"Abdelhanine","family":"Ayad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4118-6302","authenticated-orcid":false,"given":"Siemowit","family":"Muszy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-771X","authenticated-orcid":false,"given":"Monika","family":"Stefaniuk-Szmukier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jevs.2026.105877_bib0001","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature11399","article-title":"Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice","volume":"488","author":"Andersson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jevs.2026.105877_bib0002","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/age.12228","article-title":"Gaitedness is associated with the DMRT3 \u2018Gait keeper\u2019 mutation in Morgan and American Curly horses","volume":"45","author":"J\u00e4derkvist","year":"2014","journal-title":"Anim Genet"},{"key":"10.1016\/j.jevs.2026.105877_bib0003","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.3390\/ani13162557","article-title":"The characteristics, distribution, function, and origin of alternative lateral horse gaits","volume":"13","author":"Vincelette","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.jevs.2026.105877_bib0004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.livsci.2015.03.025","article-title":"The importance of the DMRT3 \u2018gait keeper\u2019 mutation on riding traits and gaits in standardbred and Icelandic horses","volume":"176","author":"J\u00e4derkvist","year":"2015","journal-title":"Livest Sci"},{"key":"10.1016\/j.jevs.2026.105877_bib0005","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1080\/10495398.2023.2206866","article-title":"Identification and characterization of single nucleotide polymorphisms in DMRT3 gene in Indian horse (Equus caballus) and donkey (Equus asinus) populations","volume":"34","author":"Sonali","year":"2023","journal-title":"Anim Biotechnol"},{"key":"10.1016\/j.jevs.2026.105877_bib0006","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/age.12120","article-title":"Worldwide frequency distribution of the \u2018 Gait keeper \u2019 mutation in the DMRT3 gene","volume":"45","author":"Promerov\u00e1","year":"2014","journal-title":"Anim Genet"},{"key":"10.1016\/j.jevs.2026.105877_bib0007","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/age.12458","article-title":"Comparison of DMRT3 genotypes among American saddlebred horses with reference to gait","volume":"47","author":"Regatieri","year":"2016","journal-title":"Anim Genet"},{"key":"10.1016\/j.jevs.2026.105877_bib0008","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/evj.14525","article-title":"Adaptation strategies of Icelandic horses with induced transient hindlimb lameness at walk, trot and t\u00f6lt","volume":"58","author":"Rhodin","year":"2026","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2026.105877_bib0009","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/jbg.12112","article-title":"The effect of the \u2018Gait keeper\u2019 mutation in the DMRT3 gene on gaiting ability in Icelandic horses","volume":"131","author":"Kristjansson","year":"2014","journal-title":"J Anim Breed Genet"},{"key":"10.1016\/j.jevs.2026.105877_bib0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12711-015-0095-7","article-title":"Does heterozygosity at the DMRT3 gene make French trotters better racers?","volume":"47","author":"Ricard","year":"2015","journal-title":"Genet Sel Evol"},{"key":"10.1016\/j.jevs.2026.105877_bib0011","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jevs.2015.09.001","article-title":"MSTN, CKM, and DMRT3 gene variants in different lines of quarter horses","volume":"39","author":"Pereira","year":"2016","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.jevs.2026.105877_bib0012","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/429864","article-title":"A note on exact tests of Hardy-Weinberg equilibrium","volume":"76","author":"Wigginton","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jevs.2026.105877_bib0013","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jevs.2026.105877_bib0014","doi-asserted-by":"crossref","first-page":"e4792","DOI":"10.1002\/pro.4792","article-title":"ChimeraX : tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci"},{"key":"10.1016\/j.jevs.2026.105877_bib0015","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1002\/cpbi.99","article-title":"Analyzing protein disorder with IUPred2A","volume":"70","author":"Erd\u0151s","year":"2020","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.jevs.2026.105877_bib0016","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/pro.3779","article-title":"ConSurf-DB: an accessible repository for the evolutionary conservation patterns of the majority of PDB proteins","volume":"29","author":"Ben Chorin","year":"2020","journal-title":"Protein Sci"},{"key":"10.1016\/j.jevs.2026.105877_bib0017","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gkad1058","article-title":"ELM\u2014the eukaryotic Linear Motif resource\u20142024 update","volume":"52","author":"Kumar","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jevs.2026.105877_bib0018","doi-asserted-by":"crossref","first-page":"W122","DOI":"10.1093\/nar\/gkad472","article-title":"DDMut: predicting effects of mutations on protein stability using deep learning","volume":"51","author":"Zhou","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jevs.2026.105877_bib0019","doi-asserted-by":"crossref","first-page":"W306","DOI":"10.1093\/nar\/gki375","article-title":"I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure","volume":"33","author":"Capriotti","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jevs.2026.105877_bib0020","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1038\/s41467-020-19669-x","article-title":"Inferring the molecular and phenotypic impact of amino acid variants with MutPred2","volume":"11","author":"Pejaver","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jevs.2026.105877_bib0021","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.3390\/ani13243829","article-title":"DMRT3 Allele frequencies in Batida- and Picada-gaited donkeys and mules in Brazil","volume":"13","author":"Herman","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.jevs.2026.105877_bib0022","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12711-023-00863-6","article-title":"The genetics of gaits in Icelandic horses goes beyond DMRT3, with RELN and STAU2 identified as two new candidate genes","volume":"55","author":"Sigur\u00f0ard\u00f3ttir","year":"2023","journal-title":"Genet Sel Evol"},{"key":"10.1016\/j.jevs.2026.105877_bib0023","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1523\/JNEUROSCI.0326-18.2018","article-title":"Characterization of Dmrt3-derived neurons suggest a role within locomotor circuits","volume":"39","author":"Perry","year":"2019","journal-title":"J Neurosci"},{"key":"10.1016\/j.jevs.2026.105877_bib0024","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/age.12610","article-title":"To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 \u2018Gait Keeper\u2019 mutation","volume":"48","author":"Fegraeus","year":"2017","journal-title":"Anim Genet"},{"key":"10.1016\/j.jevs.2026.105877_bib0025","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/evj.13998","article-title":"Adaptation strategies of the Icelandic horse with induced forelimb lameness at walk, trot and t\u00f6lt","volume":"56","author":"Smit","year":"2024","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2026.105877_bib0026","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/jbg.12526","article-title":"Genomic analysis of gaits and racing performance of the French trotter","volume":"138","author":"Ricard","year":"2021","journal-title":"J Anim Breed Genet"},{"key":"10.1016\/j.jevs.2026.105877_bib0027","first-page":"679","article-title":"DMRT3 gene mutation and highly linked SNP in gaitedness horse breeds","volume":"24","author":"Lukanova","year":"2018","journal-title":"Bulg J Agric Sci"},{"key":"10.1016\/j.jevs.2026.105877_bib0028","first-page":"1233","article-title":"First detection of the DMRT3 \u201eGait Keeper\u201d mutation in horse breeds in Bulgaria","volume":"27","author":"Lukanova","year":"2021","journal-title":"Bulg J Agric Sci"},{"key":"10.1016\/j.jevs.2026.105877_bib0029","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/age.12580","article-title":"The evolutionary history of the DMRT3 \u2018Gait keeper\u2019 haplotype","volume":"48","author":"Staiger","year":"2017","journal-title":"Anim Genet"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626001139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626001139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:35:43Z","timestamp":1777271743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0737080626001139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":29,"alternative-id":["S0737080626001139"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2026.105877","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DMRT3 gene variations in horse breeds selected for gaited movement \u2013 established research and novel findings","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2026.105877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105877"}}