{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:34:27Z","timestamp":1777275267787,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jevs.2026.105878","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:43:11Z","timestamp":1775230991000},"page":"105878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Periovulatory administration of therapeutic and supratherapeutic doses of firocoxib does not impair induced ovulation or follicular dynamics in mares treated with a GnRH analogue"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3488-9452","authenticated-orcid":false,"given":"L.G.","family":"Faria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Zutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.P.","family":"Freitas-Dell\u2019Aqua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.L.","family":"Camillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.S.","family":"\u00c1vila-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.S.","family":"Bassetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.C.","family":"Marcolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Alvarenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10\u201311","key":"10.1016\/j.jevs.2026.105878_bib0001","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0039-128X(00)00114-8","article-title":"Ovulation: a multi-gene, multi-step process","volume":"65","author":"Robker","year":"2000","journal-title":"Steroids"},{"key":"10.1016\/j.jevs.2026.105878_bib0002","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.theriogenology.2022.11.042","article-title":"The effect of dexamethasone and flunixin-meglumine on ovulation, endometrial oedema, and inter-ovulatory interval length in the mare","volume":"197","author":"Mart\u00ednez-Bov\u00ed","year":"2023","journal-title":"Theriogenology"},{"issue":"5","key":"10.1016\/j.jevs.2026.105878_bib0003","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/rda.12586","article-title":"Does clinical treatment with phenylbutazone and meloxicam in the pre-ovulatory period influence the ovulation rate in mares?","volume":"50","author":"Lima","year":"2015","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.jevs.2026.105878_bib0004","series-title":"Equine reproduction","author":"McKinnon","year":"2007"},{"key":"10.1016\/j.jevs.2026.105878_bib0005","first-page":"64","article-title":"Postbreeding uterine fluid accumulation in a normal population of thoroughbred mares: a field study","author":"Zent","year":"1998","journal-title":"Proc Am Assoc Equine Pract"},{"issue":"3","key":"10.1016\/j.jevs.2026.105878_bib0006","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1530\/REP-15-0457","article-title":"The mare as a model for luteinized unruptured follicle syndrome: intrafollicular endocrine milieu","volume":"151","author":"Bashir","year":"2016","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.jevs.2026.105878_bib0007","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.theriogenology.2010.10.011","article-title":"Systemic treatment with high dose of flunixin-meglumine is able to block ovulation in mares by inducing hemorrhage and luteinisation of follicles","volume":"75","author":"Cuervo-Arango","year":"2011","journal-title":"Theriogenology"},{"key":"10.1016\/j.jevs.2026.105878_bib0008","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.theriogenology.2019.06.045","article-title":"Periovulatory administration of firocoxibe did not alter ovulation rates and mitigated post-breeding inflammatory response in mares","volume":"138","author":"Friso","year":"2019","journal-title":"Theriogenology"},{"issue":"1","key":"10.1016\/j.jevs.2026.105878_bib0009","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13396","article-title":"Evidence for anti-inflammatory effects of firocoxib administered to mares with experimentally induced placentitis","volume":"86","author":"Macpherson","year":"2021","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.jevs.2026.105878_bib0011","article-title":"Use of different ovulation inductors in equine","volume":"89","author":"Jardim","year":"2020","journal-title":"J Equine Veterin Sci"},{"key":"10.1016\/j.jevs.2026.105878_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jevs.2025.105657","article-title":"Clinical safety of intrauterine infusion of a uterine sanitizer in mares","author":"Segabinazzi","year":"2025","journal-title":"J Equine Veterin Sci"},{"issue":"1\u20132","key":"10.1016\/j.jevs.2026.105878_bib0013","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.anireprosci.2011.07.008","article-title":"The effect of treatment with flunixin meglumine at different times relative to hCG administration on ovulation failure and luteal function in mares","volume":"127","author":"Cuervo-Arango","year":"2011","journal-title":"Animal Reprod Sci"},{"issue":"11","key":"10.1016\/j.jevs.2026.105878_bib0014","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2460\/ajvr.69.11.1399","article-title":"Pharmacokinetics of firocoxib after administration of multiple consecutive daily doses to horses","volume":"69","author":"Letendre","year":"2008","journal-title":"Am J Vet Res"},{"issue":"2","key":"10.1016\/j.jevs.2026.105878_bib0015","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/jvp.12253","article-title":"Disposition of firocoxibe in late pregnant and early postpartum mares","volume":"39","author":"Gigu\u00e8re","year":"2016","journal-title":"J Vet Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.jevs.2026.105878_bib0016","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1210\/endo.138.10.5462","article-title":"The late induction of prostaglandin G\/H synthase-2 in equine preovulatory follicles supports its role as a determinant of the ovulatory process","volume":"138","author":"Sirois","year":"1997","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.jevs.2026.105878_bib0017","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/humupd\/dmh032","article-title":"Cyclooxygenase-2 and its role in ovulation: a 2004 account","volume":"10","author":"Sirois","year":"2004","journal-title":"Human Reprod Update"},{"issue":"11","key":"10.1016\/j.jevs.2026.105878_bib0018","doi-asserted-by":"crossref","first-page":"10649","DOI":"10.1074\/jbc.M312203200","article-title":"Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup","volume":"279","author":"Wang","year":"2004","journal-title":"J Biolog Chem"},{"issue":"4","key":"10.1016\/j.jevs.2026.105878_bib0019","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1262\/jrd.2021-148","article-title":"Effects of different cyclooxygenase inhibitors on prostaglandin E2 production, steroidogenesis and ovulation of bovine preovulatory follicles","volume":"68","author":"Vernunft","year":"2022","journal-title":"J Reprod Dev"},{"issue":"7","key":"10.1016\/j.jevs.2026.105878_bib0020","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/humrep\/16.7.1323","article-title":"Induction of delayed follicular rupture in the human by the selective COX-2 inhibitor rofecoxib: a randomized double-blind study","volume":"16","author":"Pall","year":"2001","journal-title":"Human Reprod"},{"key":"10.1016\/j.jevs.2026.105878_bib0021","series-title":"Reproductive biology of the mare: basic and applied aspects","author":"Ginther","year":"1979"},{"issue":"4","key":"10.1016\/j.jevs.2026.105878_bib0022","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.phrs.2005.04.004","article-title":"COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis","volume":"52","author":"Beretta","year":"2005","journal-title":"Pharmacolog Research"},{"issue":"6","key":"10.1016\/j.jevs.2026.105878_bib0023","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2885.2004.00617.x","article-title":"Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest","volume":"27","author":"Lees","year":"2004","journal-title":"J Vet Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.jevs.2026.105878_bib0024","first-page":"385","article-title":"Pharmacokinetics and metabolism of firocoxibe in horses after oral administration","volume":"68","author":"Kvaternick","year":"2007","journal-title":"Am J Vet Res"},{"issue":"4","key":"10.1016\/j.jevs.2026.105878_bib0025","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/eve.13280","article-title":"Ex vivo COX-1 and COX-2 inhibition in equine blood by phenylbutazone, flunixin meglumine, meloxicam and firocoxib: informing clinical NSAID selection","volume":"33","author":"Fogle","year":"2021","journal-title":"Equine Vet Edu"},{"key":"10.1016\/j.jevs.2026.105878_bib0026","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jevs.2017.10.023","article-title":"Effect of the flunixin meglumine on pregnancy rates in an equine embryo transfer program","volume":"62","author":"Okada","year":"2018","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.jevs.2026.105878_bib0027","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/rda.14390","article-title":"General and comparative aspects of endometritis in domestic species: a review","volume":"58","author":"Pascottini","year":"2023","journal-title":"Reprod Domestic Animals"},{"issue":"6","key":"10.1016\/j.jevs.2026.105878_bib0028","first-page":"256","article-title":"Hematological and biochemical effects associated with prolonged administration of the NSAID firocoxib in adult healthy horses","volume":"11","author":"Ign\u00e1cio","year":"2024","journal-title":"Vet Sci"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626001140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626001140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:36:37Z","timestamp":1777271797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0737080626001140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":27,"alternative-id":["S0737080626001140"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2026.105878","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Periovulatory administration of therapeutic and supratherapeutic doses of firocoxib does not impair induced ovulation or follicular dynamics in mares treated with a GnRH analogue","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2026.105878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105878"}}