{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:30:35Z","timestamp":1786116635471,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006668","name":"Oregon Health and Science University","doi-asserted-by":"publisher","award":["T32GM142619"],"award-info":[{"award-number":["T32GM142619"]}],"id":[{"id":"10.13039\/100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD086073-A1"],"award-info":[{"award-number":["R01HD086073-A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD105320-A1"],"award-info":[{"award-number":["R01HD105320-A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jevs.2026.106074","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:25:25Z","timestamp":1782919525000},"page":"106074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparative genomics analysis of aneuploidy and cellular fragmentation dynamics in mammalian embryos"],"prefix":"10.1016","volume":"164","author":[{"given":"R.","family":"Tippner-Hedges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2721-6373","authenticated-orcid":false,"given":"J.","family":"Budrewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-1921","authenticated-orcid":false,"given":"B.A.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Okovat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S.","family":"Metcalf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-0222","authenticated-orcid":false,"given":"S.L.","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jevs.2026.106074_bib0001","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nm.1924","article-title":"Chromosome instability is common in human cleavage-stage embryos","volume":"15","author":"Vanneste","year":"2009","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jevs.2026.106074_bib0002","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/humrep\/dep452","article-title":"Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol","volume":"25","author":"Johnson","year":"2010","journal-title":"Hum Reprod"},{"issue":"6","key":"10.1016\/j.jevs.2026.106074_bib0003","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.fertnstert.2014.08.015","article-title":"Validation of multiple annealing and looping-based amplification cycle sequencing for 24-chromosome aneuploidy screening of cleavage-stage embryos","volume":"102","author":"Huang","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jevs.2026.106074_bib0004","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1477-7827-12-105","article-title":"Array comparative genomic hybridization analyses of all blastomeres of a cohort of embryos from young IVF patients revealed significant contribution of mitotic errors to embryo mosaicism at the cleavage stage","volume":"12","author":"Chow","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"issue":"10","key":"10.1016\/j.jevs.2026.106074_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005601","article-title":"Evidence of selection against complex mitotic-origin aneuploidy during preimplantation development","volume":"11","author":"McCoy","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jevs.2026.106074_bib0006","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/ncomms2249","article-title":"Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage","volume":"3","author":"Chavez","year":"2012","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jevs.2026.106074_bib0007","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1101\/gr.200527.115","article-title":"Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage-stage chimerism and mixoploidy","volume":"26","author":"Destouni","year":"2016","journal-title":"Genome Res"},{"issue":"1","key":"10.1016\/j.jevs.2026.106074_bib0008","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000452923","article-title":"Aneuploidy detection and mtDNA quantification in bovine embryos with different cleavage onset using a next-generation sequencing-based protocol","volume":"150","author":"Hornak","year":"2016","journal-title":"Cytogenet Genome Res"},{"issue":"11","key":"10.1016\/j.jevs.2026.106074_bib0009","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/humrep\/dex286","article-title":"Genome stability of bovine in vivo-conceived cleavage-stage embryos is higher compared to in vitro-produced embryos","volume":"32","author":"Tsuiko","year":"2017","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.jevs.2026.106074_bib0010","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1101\/gr.239830.118","article-title":"Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion","volume":"29","author":"Daughtry","year":"2019","journal-title":"Genome Res"},{"issue":"4","key":"10.1016\/j.jevs.2026.106074_bib0011","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1095\/biolreprod.115.135483","article-title":"Next generation sequencing-based comprehensive chromosome screening in mouse polar bodies, oocytes, and embryos","volume":"94","author":"Treff","year":"2016","journal-title":"Biol Reprod"},{"issue":"6","key":"10.1016\/j.jevs.2026.106074_bib0012","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nmeth.3370","article-title":"G&T-seq: parallel sequencing of single-cell genomes and transcriptomes","volume":"12","author":"Macaulay","year":"2015","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.jevs.2026.106074_bib0013","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/s41598-023-48103-7","article-title":"Genome-wide equine preimplantation genetic testing enabled by simultaneous haplotyping and copy number detection","volume":"14","author":"De Coster","year":"2024","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jevs.2026.106074_bib0014","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/humrep\/14.2.429","article-title":"Temporal and spatial aspects of fragmentation in early human embryos: possible effects on developmental competence and association with the differential elimination of regulatory proteins from polarized domains","volume":"14","author":"Antczak","year":"1999","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.jevs.2026.106074_bib0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0002-9378(85)90116-4","article-title":"Biologic and morphologic development of donated human ova recovered by nonsurgical uterine lavage","volume":"153","author":"Buster","year":"1985","journal-title":"Am J Obs Gynecol"},{"issue":"3","key":"10.1016\/j.jevs.2026.106074_bib0016","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1095\/biolreprod18.3.481","article-title":"Ultrastructure of a seven-cell human embryo","volume":"18","author":"Pereda","year":"1978","journal-title":"Biol Reprod"},{"key":"10.1016\/j.jevs.2026.106074_bib0017","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-1-4939-7780-2_19","article-title":"Time-lapse imaging for the detection of chromosomal abnormalities in primate preimplantation embryos","volume":"1769","author":"Daughtry","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"4","key":"10.1016\/j.jevs.2026.106074_bib0018","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1095\/biolreprod.102.013243","article-title":"Chronology of apoptosis in bovine embryos produced in vivo and in vitro","volume":"69","author":"Gjorret","year":"2003","journal-title":"Biol Reprod"},{"issue":"4","key":"10.1016\/j.jevs.2026.106074_bib0019","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1530\/rep.1.00533","article-title":"Porcine embryo development and fragmentation and their relation to apoptotic markers: a cinematographic and confocal laser scanning microscopic study","volume":"129","author":"Mateusen","year":"2005","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.jevs.2026.106074_bib0020","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/humrep\/13.5.1307","article-title":"The impact of cellular fragmentation induced experimentally at different stages of mouse preimplantation development","volume":"13","author":"Dozortsev","year":"1998","journal-title":"Hum Reprod"},{"issue":"18","key":"10.1016\/j.jevs.2026.106074_bib0021","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1093\/hmg\/ddu212","article-title":"Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres","volume":"23","author":"Chavez","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.jevs.2026.106074_bib0022","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1095\/biolreprod.103.018515","article-title":"Effects of in vitro production on horse embryo morphology, cytoskeletal characteristics, and blastocyst capsule formation","volume":"69","author":"Tremoleda","year":"2003","journal-title":"Biol Reprod"},{"issue":"12","key":"10.1016\/j.jevs.2026.106074_bib0023","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1071\/RD19254","article-title":"Assessing equine embryo developmental competency by time-lapse image analysis","volume":"31","author":"Brooks","year":"2019","journal-title":"Reprod Fertil Dev"},{"issue":"8","key":"10.1016\/j.jevs.2026.106074_bib0024","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/mrd.21028","article-title":"Effects of culture medium and protein supplementation on mRNA expression of in vitro produced bovine embryos","volume":"76","author":"Purpera","year":"2009","journal-title":"Mol Reprod Dev"},{"issue":"45","key":"10.1016\/j.jevs.2026.106074_bib0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/evj.12159","article-title":"Effect of potential oocyte transport protocols on blastocyst rates after intracytoplasmic sperm injection in the horse","volume":"45","author":"Foss","year":"2013","journal-title":"Equine Vet J Suppl"},{"key":"10.1016\/j.jevs.2026.106074_bib0026","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1477-7827-2-32","article-title":"Overriding follicle selection in controlled ovarian stimulation protocols: quality vs quantity","volume":"2","author":"Stouffer","year":"2004","journal-title":"Reprod Biol Endocrinol"},{"issue":"11","key":"10.1016\/j.jevs.2026.106074_bib0027","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/nprot.2016.138","article-title":"Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T-seq","volume":"11","author":"Macaulay","year":"2016","journal-title":"Nat Protoc"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626003096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0737080626003096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:37:44Z","timestamp":1786016264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0737080626003096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S0737080626003096"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2026.106074","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative genomics analysis of aneuploidy and cellular fragmentation dynamics in mammalian embryos","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2026.106074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106074"}}