{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:55:02Z","timestamp":1791413702567,"version":"4.3.3"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00772\/2020"],"award-info":[{"award-number":["UIDB\/00772\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Equine Veterinary Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jevs.2026.106158","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:28:07Z","timestamp":1790519287000},"page":"106158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between matrix Metalloproteinase-9 (MMP-9) immunohistochemical expression and clinicopathological features in equine melanoma"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-2123","authenticated-orcid":false,"given":"J.","family":"Pimenta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6242-5029","authenticated-orcid":false,"given":"D.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-5374","authenticated-orcid":false,"given":"J.","family":"Prada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Garcez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-0240","authenticated-orcid":false,"given":"L.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-6515","authenticated-orcid":false,"given":"M.","family":"Cotovio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jevs.2026.106158_bib0001","series-title":"Equine oncology: an issue of veterinary clinics of North America","first-page":"431","article-title":"Equine melanoma updates","author":"Hollis","year":"2024"},{"key":"10.1016\/j.jevs.2026.106158_bib0002","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.2042-3292.2011.00368.x","article-title":"Melanoma in horses: current perspectives","volume":"25","author":"Moore","year":"2013","journal-title":"Equine Vet Educ"},{"key":"10.1016\/j.jevs.2026.106158_bib0003","doi-asserted-by":"crossref","first-page":"455","DOI":"10.21836\/PEM20140410","article-title":"Aetiology, clinical presentation and current treatment options of equine malignant melanoma - A review of the literature","volume":"30","author":"Cavalleri","year":"2014","journal-title":"Pferdeheilkunde"},{"key":"10.1016\/j.jevs.2026.106158_bib0004","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/eve.12767","article-title":"Surgical excision of large melanocytic tumours in grey horses: 38 cases (2001\u20132013)","volume":"30","author":"Groom","year":"2018","journal-title":"Equine Vet Educ"},{"key":"10.1016\/j.jevs.2026.106158_bib0005","doi-asserted-by":"crossref","first-page":"914","DOI":"10.2460\/javma.24.12.0816","article-title":"Surgical technique, outcome, complications, and recurrence rate for removal of extensive perianal melanomas: 50 treated horses","volume":"263","author":"Haegeman","year":"2025","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jevs.2026.106158_bib0006","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1600-0749.2004.00192.x","article-title":"Comparative histopathology of grey-horse-melanoma and Human malignant melanoma","volume":"17","author":"Seltenhammer","year":"2004","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jevs.2026.106158_bib0007","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2746\/042516403776114234","article-title":"Equine melanoma in a population of 296 grey Lipizzaner horses","volume":"35","author":"Seltenhammer","year":"2003","journal-title":"Equine Vet J"},{"key":"10.1016\/j.jevs.2026.106158_bib0008","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1939-1676.2002.tb01264.x","article-title":"Metastatic melanoma in horses","volume":"16","author":"Macgillivray","year":"2002","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jevs.2026.106158_bib0009","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3390\/cells9051151","article-title":"Functional roles of matrix metalloproteinases and their inhibitors in melanoma","volume":"9","author":"Napoli","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jevs.2026.106158_bib0010","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.3390\/ijms25147804","article-title":"Skin malignant melanoma and matrix metalloproteinases: promising links to efficient therapies","volume":"25","author":"Lazar","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0011","doi-asserted-by":"crossref","first-page":"45","DOI":"10.47162\/RJME.65.1.06","article-title":"MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis \u2013 key points in understanding the mechanisms and celerity of tumor dissemination","volume":"65","author":"Manolescu","year":"2024","journal-title":"Rom J Morphol Embryol"},{"key":"10.1016\/j.jevs.2026.106158_bib0012","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.rvsc.2017.09.009","article-title":"Gene expression profiles of cell adhesion molecules, matrix metalloproteinases and their tissue inhibitors in canine oral tumors","volume":"113","author":"Pisamai","year":"2017","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0013","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biochi.2005.01.013","article-title":"Role of matrix metalloproteinases in melanoma cell invasion","volume":"87","author":"Hofmann","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.jevs.2026.106158_bib0014","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.3390\/cancers12082154","article-title":"EMT-inducing transcription factors, drivers of melanoma phenotype switching, and resistance to treatment","volume":"12","author":"Tang","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jevs.2026.106158_bib0015","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ccr.2013.08.018","article-title":"A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma","volume":"24","author":"Caramel","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jevs.2026.106158_bib0016","article-title":"MMP-2 and MMP-9 expression in canine cutaneous melanocytic tumours: evidence of a relationship with tumoural malignancy","author":"Pires","year":"2013","journal-title":"InTech"},{"key":"10.1016\/j.jevs.2026.106158_bib0017","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2460\/ajvr.72.8.1087","article-title":"Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines","volume":"72","author":"Docampo","year":"2011","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jevs.2026.106158_bib0018","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/cncr.10888","article-title":"Immunohistochemical expression of vascular endothelial growth factor, matrix metalloproteinase 2, and matrix metalloproteinase 9 in cutaneous melanocytic lesions","volume":"95","author":"Simonetti","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jevs.2026.106158_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413558","article-title":"Targeting matrix metalloproteinases and their inhibitors in Melanoma","volume":"25","author":"Szczygielski","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0020","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.3390\/ani13132216","article-title":"E-cadherin immunostaining in equine melanocytic tumors","volume":"13","author":"Pimenta","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.jevs.2026.106158_bib0021","doi-asserted-by":"crossref","DOI":"10.1186\/s12917-016-0648-1","article-title":"Extracellular matrix remodeling in equine sarcoid: an immunohistochemical and molecular study","volume":"12","author":"Martano","year":"2016","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jevs.2026.106158_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jevs.2020.103338","article-title":"Immunohistochemical analysis of programmed death-ligand 1 expression in equine sarcoids","volume":"97","author":"Benvegnen","year":"2021","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0023","series-title":"Equine oncology: an issue of veterinary clinics of North America","first-page":"371","article-title":"Surgical management of equine neoplasia","author":"Jackson","year":"2024"},{"key":"10.1016\/j.jevs.2026.106158_bib0024","series-title":"Equine oncology, an issue of veterinary clinics of North America","first-page":"13","article-title":"Equine oncology: why does it matter anyway?","author":"Hollis","year":"2024"},{"key":"10.1016\/j.jevs.2026.106158_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.633170","article-title":"COX-2 silencing in canine malignant melanoma inhibits malignant behaviour","volume":"8","author":"Silveira","year":"2021","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0026","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-017-0585-2","article-title":"Combination therapy of PKC\u03b6 and COX-2 inhibitors synergistically suppress melanoma metastasis","volume":"36","author":"Zhou","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.jevs.2026.106158_bib0027","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-14-857","article-title":"Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses","volume":"14","author":"Jiang","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jevs.2026.106158_bib0028","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/vetsci10010019","article-title":"An overview of epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition in canine tumors: how far have we come?","volume":"10","author":"Armando","year":"2023","journal-title":"Vet Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0029","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cveq.2013.08.008","article-title":"Equine melanocytic tumors","volume":"29","author":"Phillips","year":"2013","journal-title":"Vet Clin N Am - Equine Pract"},{"key":"10.1016\/j.jevs.2026.106158_bib0030","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3390\/cells13110956","article-title":"Deregulation of metalloproteinase expression in gray horse melanoma ex vivo and In vitro","volume":"13","author":"Brodesser","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jevs.2026.106158_bib0031","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.virol.2009.10.010","article-title":"Equine sarcoid fibroblasts over-express matrix metalloproteinases and are invasive","volume":"396","author":"Yuan","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.jevs.2026.106158_bib0032","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tvjl.2014.07.026","article-title":"Equine sarcoid: in situ demonstration of matrix metalloproteinase expression","volume":"202","author":"Mosseri","year":"2014","journal-title":"Vet J"},{"key":"10.1016\/j.jevs.2026.106158_bib0033","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/03009858231209408","article-title":"Equine sarcoids: a clinicopathologic study of 49 cases, with mitotic count and clinical type predictive of recurrence","volume":"61","author":"Karalus","year":"2024","journal-title":"Vet Pathol"},{"key":"10.1016\/j.jevs.2026.106158_bib0034","doi-asserted-by":"crossref","DOI":"10.5772\/54878","article-title":"MMP-2 and MMP-9 expression in canine cutaneous melanocytic tumours: evidence of a relationship with tumoural malignancy","author":"Pires","year":"2013","journal-title":"Recent Adv Biol Ther Manag Melanoma"},{"key":"10.1016\/j.jevs.2026.106158_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1624598","article-title":"Comparative pathophysiology and molecular insights into cutaneous and non-cutaneous canine skin cancers: focus on melanoma, mast cell tumors, and squamous cell carcinoma","volume":"16","author":"M\u00e2rza","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jevs.2026.106158_bib0036","article-title":"Melanoma of the dog and cat: consensus and guidelines","volume":"11","author":"Polton","year":"2024","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0037","doi-asserted-by":"crossref","DOI":"10.5772\/59480","article-title":"Current insights into canine cutaneous melanocytic tumours diagnosis","author":"Resende","year":"2015","journal-title":"Melanoma - Curr Clin Manag Future Ther"},{"key":"10.1016\/j.jevs.2026.106158_bib0038","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/vetsci3010007","article-title":"Comparative aspects of canine melanoma","volume":"3","author":"Nishiya","year":"2016","journal-title":"Vet Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0039","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/vetsci13040343","article-title":"In vitro characterization of an equinized anti-PD-L1 antibody for cancer immunotherapy in horses","volume":"13","author":"Horikawa","year":"2026","journal-title":"Vet Sci"},{"key":"10.1016\/j.jevs.2026.106158_bib0040","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3390\/ani11072121","article-title":"Pd-l1\/pd-1 and ctla-4 expression in equine penile squamous cell carcinomas","volume":"11","author":"Porcellato","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.jevs.2026.106158_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234218","article-title":"PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade","volume":"15","author":"Ganbaatar","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jevs.2026.106158_bib0042","doi-asserted-by":"crossref","first-page":"448","DOI":"10.21836\/PEM20150504","article-title":"Prospect for immunological therapies of the equine malignant melanoma","volume":"31","author":"Cavalleri","year":"2015","journal-title":"Pferdeheilkunde"},{"key":"10.1016\/j.jevs.2026.106158_bib0043","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1158\/2326-6066.CIR-18-0086","article-title":"Stromal fibroblasts mediate anti\u2013PD-1 resistance via MMP-9 and dictate TGFb inhibitor sequencing in melanoma","volume":"6","author":"Zhao","year":"2018","journal-title":"Cancer Immunol Res"}],"container-title":["Journal of Equine Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073708062600393X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073708062600393X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:38:02Z","timestamp":1791412682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073708062600393X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":43,"alternative-id":["S073708062600393X"],"URL":"https:\/\/doi.org\/10.1016\/j.jevs.2026.106158","relation":{},"ISSN":["0737-0806"],"issn-type":[{"value":"0737-0806","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between matrix Metalloproteinase-9 (MMP-9) immunohistochemical expression and clinicopathological features in equine melanoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Equine Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jevs.2026.106158","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106158"}}