{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:11:56Z","timestamp":1790622716778,"version":"4.1.0"},"reference-count":20,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"4","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":956,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Core Facility Program for Biotechnology of National Science Council"},{"name":"National Research Program for Genomic Medicine","award":["NSC 98-3112-B-400-011, NSC 99-3112-B-400-003, and NSC 100-3112-B-400-015"],"award-info":[{"award-number":["NSC 98-3112-B-400-011, NSC 99-3112-B-400-003, and NSC 100-3112-B-400-015"]}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 97-2314-B-400-001-MY3 and NSC 100-2314-B-400-002-MY3"],"award-info":[{"award-number":["NSC 97-2314-B-400-001-MY3 and NSC 100-2314-B-400-002-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"crossref","award":["PH-098-PP-41, PH-098-PP-46, PH-098-PP-38, PH-098, 99-PP-42, PH-100-PP-37, PH-101-PP-32 and PH-98, 99, 100-SP-11, NHRI-101A1-PDCO-1312141"],"award-info":[{"award-number":["PH-098-PP-41, PH-098-PP-46, PH-098-PP-38, PH-098, 99-PP-42, PH-100-PP-37, PH-101-PP-32 and PH-98, 99, 100-SP-11, NHRI-101A1-PDCO-1312141"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jfda-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food and Drug Analysis"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.jfda.2013.09.036","type":"journal-article","created":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T21:45:16Z","timestamp":1382219116000},"page":"S62-S68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"S","title":["Pharmacogenomics study in a Taiwanese methadone maintenance cohort"],"prefix":"10.38212","volume":"21","author":[{"given":"Sheng-Chang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Hui","family":"Tsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ing-Kang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keh-Ming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25385","reference":[{"key":"10.1016\/j.jfda.2013.09.036_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00007691-200404000-00010","article-title":"Therapeutic drug monitoring of psychotropic drugs: TDM \u201cnouveau\u201d","volume":"26","author":"Bengtsson","year":"2004","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jfda.2013.09.036_bib2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.euroneuro.2012.02.002","article-title":"Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients","volume":"22","author":"Wang","year":"2012","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jfda.2013.09.036_bib3","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/j.1360-0443.2008.02284.x","article-title":"Development of the treatment outcomes profile","volume":"103","author":"Marsden","year":"2008","journal-title":"Addiction"},{"key":"10.1016\/j.jfda.2013.09.036_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/02791072.2003.10400007","article-title":"The Clinical Opiate Withdrawal Scale (COWS)","volume":"35","author":"Wesson","year":"2003","journal-title":"J Psychoactive Drugs"},{"key":"10.1016\/j.jfda.2013.09.036_bib5","series-title":"ECDEU assessment manual for psychopharmacology","author":"Guy","year":"1976"},{"key":"10.1016\/j.jfda.2013.09.036_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/JCP.0b013e318222b5dd","article-title":"CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer","volume":"31","author":"Wang","year":"2011","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.jfda.2013.09.036_bib7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2217\/pgs.12.69","article-title":"UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients","volume":"13","author":"Tian","year":"2012","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.jfda.2013.09.036_bib8","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/bmc.1363","article-title":"Development of a method to measure methadone enantiomers and its metabolites without enantiomer standard compounds for the plasma of methadone maintenance patients","volume":"24","author":"Wang","year":"2010","journal-title":"Biomed Chromatogr"},{"key":"10.1016\/j.jfda.2013.09.036_bib9","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ajmg.b.30510","article-title":"Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction","volume":"144B","author":"Gerra","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.jfda.2013.09.036_bib10","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/ajmg.b.30701","article-title":"Multiple OPR genes influence personality traits in substance-dependent and healthy subjects in two American populations","volume":"147B","author":"Luo","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.jfda.2013.09.036_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.pnpbp.2011.10.018","article-title":"Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population","volume":"36","author":"Kumar","year":"2012","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jfda.2013.09.036_bib12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2217\/pgs.11.103","article-title":"Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients","volume":"12","author":"Chen","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.jfda.2013.09.036_bib13","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1089\/omi.2012.0068","article-title":"Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort","volume":"17","author":"Wang","year":"2013","journal-title":"OMICS"},{"key":"10.1016\/j.jfda.2013.09.036_bib14","doi-asserted-by":"crossref","first-page":"W635","DOI":"10.1093\/nar\/gkl236","article-title":"FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization","volume":"34","author":"Yuan","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jfda.2013.09.036_bib15","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2144\/jun0204","article-title":"A strategy for the rapid discovery of disease markers using the MassARRAY (TM) system","volume":"32","author":"Rodi","year":"2002","journal-title":"BioTechniques"},{"key":"10.1016\/j.jfda.2013.09.036_bib16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clinbiochem.2004.12.005","article-title":"Genotyping single nucleotide polymorphisms by MALDI mass spectrometry in clinical applications","volume":"38","author":"Tost","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jfda.2013.09.036_bib17","first-page":"289","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J\u00a0R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.jfda.2013.09.036_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jfda.2013.09.036_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/chir.10303","article-title":"Stereoselective metabolism of methadone N-demethylation by cytochrome P450 2B6 and 2C19","volume":"16","author":"Gerber","year":"2004","journal-title":"Chirality"},{"key":"10.1016\/j.jfda.2013.09.036_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/jhg.2012.139","article-title":"OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study","volume":"58","author":"Chen","year":"2013","journal-title":"J Hum Genet"}],"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949813001002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949813001002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949813001002?httpAccept=text\/plain","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T18:16:02Z","timestamp":1666635362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1021949813001002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1021949813001002"],"URL":"https:\/\/doi.org\/10.1016\/j.jfda.2013.09.036","relation":{},"ISSN":["1021-9498"],"issn-type":[{"value":"1021-9498","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacogenomics study in a Taiwanese methadone maintenance cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Food and Drug Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfda.2013.09.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}