{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:05:36Z","timestamp":1759529136769,"version":"3.41.0"},"reference-count":40,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T00:00:00Z","timestamp":1436745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"US Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"Food and Drug Administration (FDA)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jfda-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food and Drug Analysis"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jfda.2015.06.001","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T18:54:36Z","timestamp":1436036076000},"page":"577-586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis and phototoxicity of isomeric 7,9-diglutathione pyrrole adducts: Formation of reactive oxygen species and induction of lipid peroxidation"],"prefix":"10.38212","volume":"23","author":[{"given":"Liang","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lining","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"25385","reference":[{"year":"1986","series-title":"Chemistry and toxicology of pyrrolizidine alkaloids","author":"Mattocks","key":"10.1016\/j.jfda.2015.06.001_bib1"},{"key":"10.1016\/j.jfda.2015.06.001_bib2","first-page":"41","article-title":"Human health implications of pyrrolizidine alkaloids and herbs containing them","volume":"vol. 1","author":"Huxtable","year":"1989"},{"key":"10.1016\/j.jfda.2015.06.001_bib3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1081\/GNC-100107580","article-title":"Genotoxic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides \u2013 mechanisms leading to DNA adduct formation and tumorigenicity","volume":"19","author":"Fu","year":"2001","journal-title":"J Environ Sci Health, Part C"},{"key":"10.1016\/j.jfda.2015.06.001_bib4","first-page":"198","article-title":"Pyrrolizidine alkaloids-tumorigenic components in Chinese herbal medicines and dietary supplements","volume":"10","author":"Fu","year":"2002","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.jfda.2015.06.001_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1081\/DMR-120028426","article-title":"Pyrrolizidine alkaloids-genotoxicity, metabolism enzymes, metabolic activation, and mechanisms","volume":"36","author":"Fu","year":"2004","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jfda.2015.06.001_bib6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1021\/tx900402x","article-title":"High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in\u00a0vitro and in\u00a0vivo","volume":"23","author":"Fu","year":"2010","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib7","first-page":"711","article-title":"Medicinal plants in China containing pyrrolizidine alkaloids","volume":"55","author":"Roeder","year":"2000","journal-title":"Pharmazie"},{"key":"10.1016\/j.jfda.2015.06.001_bib8","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jf0114482","article-title":"Honey from plants containing pyrrolizidine alkaloids: a potential threat to health","volume":"50","author":"Edgar","year":"2002","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jfda.2015.06.001_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1021\/tx500403t","article-title":"Pyrrolizidine alkaloids: potential role in the etiology of cancers, pulmonary hypertension, congenital anomalies, and liver disease","volume":"28","author":"Edgar","year":"2015","journal-title":"Chem Res Toxicol"},{"year":"1989","series-title":"Health and Safety Criteria Guide 26: Pyrrolizidine Alkaloids Health and Safety Guide","author":"International Programme on Chemical Safety (IPCS)","key":"10.1016\/j.jfda.2015.06.001_bib10"},{"key":"10.1016\/j.jfda.2015.06.001_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/tx000150n","article-title":"Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in\u00a0vivo","volume":"14","author":"Yang","year":"2001","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib12","first-page":"400","article-title":"Detection, hepatotoxicity, and tumorigenicity of pyrrolizidine alkaloids in Chinese herbal plants and herbal dietary supplements","volume":"15","author":"Fu","year":"2007","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.jfda.2015.06.001_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jat.1504","article-title":"Genotoxicity of pyrrolizidine alkaloids","volume":"30","author":"Chen","year":"2010","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib14","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1021\/tx300292h","article-title":"Full structure assignments of pyrrolizidine alkaloid DNA adducts and mechanism of tumor initiation","volume":"25","author":"Zhao","year":"2012","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/tx025605i","article-title":"Human liver microsomal metabolism and DNA adduct formation of the tumorigenic pyrrolizidine alkaloid, riddelliine","volume":"16","author":"Xia","year":"2003","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib16","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1021\/tx400241c","article-title":"Pyrrolizidine alkaloids-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity","volume":"26","author":"Xia","year":"2013","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.toxlet.2011.06.020","article-title":"Photoirradiation of dehydropyrrolizidine alkaloids\u2013formation of reactive oxygen species and induction of lipid peroxidation","volume":"205","author":"Zhao","year":"2011","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jfda.2015.06.001_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1080\/10590501.2014.969980","article-title":"Metabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human HaCaT keratonicytes","volume":"32","author":"Wang","year":"2014","journal-title":"J Environ Sci Health, Part C"},{"key":"10.1016\/j.jfda.2015.06.001_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0378-4274(90)90075-W","article-title":"Isolation and identification of a pyrrolic glutathione conjugate metabolite of the pyrrolizidine alkaloid monocrotaline","volume":"51","author":"Lame","year":"1990","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jfda.2015.06.001_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/978-1-4684-5877-0_75","article-title":"Mechanisms for pyrrolizidine alkaloid activation and detoxification","volume":"283","author":"Buhler","year":"1991","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jfda.2015.06.001_bib21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0041-0101(91)90015-J","article-title":"Identity of a biliary metabolite formed from monocrotaline in isolated, perfused rat liver","volume":"29","author":"Mattocks","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.jfda.2015.06.001_bib22","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3109\/00498259209053160","article-title":"Microsomal formation of a pyrrolic alcohol glutathione conjugate of the pyrrolizidine alkaloid senecionine","volume":"22","author":"Reed","year":"1992","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jfda.2015.06.001_bib23","first-page":"181","article-title":"Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid","volume":"26","author":"Lin","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jfda.2015.06.001_bib24","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3109\/00498254.2012.679978","article-title":"Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2\/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates","volume":"42","author":"Tamta","year":"2012","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jfda.2015.06.001_bib25","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1021\/tx5002964","article-title":"Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol","volume":"27","author":"Fashe","year":"2014","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/taap.1995.1017","article-title":"Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver","volume":"130","author":"Yan","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jfda.2015.06.001_bib27","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/tx500417q","article-title":"7-Glutathione pyrrole adduct: a potential DNA reactive metabolite of pyrrolizidine alkaloids","volume":"28","author":"Xia","year":"2015","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1021\/tx000149o","article-title":"Development of a 32P-postlabeling\/HPLC method for detection of dehydroretronesine-derived DNA adducts in\u00a0vitro and in\u00a0vivo","volume":"14","author":"Yang","year":"2001","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/tx049807l","article-title":"Photodecomposition of retinyl palmitate in ethanol by UVA light \u2013 formation of photodecomposition products, reactive oxygen species, and lipid peroxides","volume":"18","author":"Cherng","year":"2005","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jfda.2015.06.001_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.toxlet.2005.09.010","article-title":"UVA photodecomposition of retinyl palmitate \u2013 formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation","volume":"163","author":"Xia","year":"2006","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jfda.2015.06.001_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jphotochem.2010.02.007","article-title":"Photoirradiation of azulene and guaiazulene\u2013formation of reactive oxygen species and induction of lipid peroxidation","volume":"211","author":"Chiang","year":"2010","journal-title":"J Photochem Photobiol A Chem"},{"key":"10.1016\/j.jfda.2015.06.001_bib32","first-page":"671","article-title":"Dosimetry of solar ultraviolet radiation. Daily and monthly changes in Paris","volume":"114","author":"Jeanmougin","year":"1987","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jfda.2015.06.001_bib33","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jfda.2015.01.004","article-title":"Absolute configuration, stability, and interconversion of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine valine adducts and their phenylthiohydantoin derivatives","volume":"23","author":"Jiang","year":"2015","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.jfda.2015.06.001_bib34","first-page":"3141","article-title":"Covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with cysteine and glutathione","volume":"37","author":"Robertson","year":"1977","journal-title":"Cancer Res"},{"key":"10.1016\/j.jfda.2015.06.001_bib35","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0090-9556(24)13677-X","article-title":"Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid","volume":"28","author":"Lin","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jfda.2015.06.001_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/ijerph2007040009","article-title":"UVA photoirradiation of methylated benzo[a]pyrene and benzo[e]pyrene leading to induction of lipid peroxidation","volume":"4","author":"Herre\u00f1o-S\u00e1enz","year":"2007","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jfda.2015.06.001_bib37","first-page":"4505","article-title":"Singlet oxygen: a primary effector in the ultraviolet A\/near-visible light induction of the human heme oxygenase gene","volume":"53","author":"Basu-Modak","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.jfda.2015.06.001_bib38","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1751-1097.1998.tb02525.x","article-title":"Molecular mechanism of photosensitization XI. Membrane damage and DNA cleavage photoinduced by enoxacin","volume":"68","author":"Sortino","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.jfda.2015.06.001_bib39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0531-5565(00)00231-X","article-title":"Oxidative biochemical markers: clues to understanding aging in long-lived species","volume":"36","author":"Floyd","year":"2001","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jfda.2015.06.001_bib40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/tx960133r","article-title":"Reactive oxygen-mediated protein oxidation in aging and disease","volume":"10","author":"Stadtman","year":"1997","journal-title":"Chem Res Toxicol"}],"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949815000745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949815000745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949815000745?httpAccept=text\/plain","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T01:03:40Z","timestamp":1748480620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1021949815000745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1021949815000745"],"URL":"https:\/\/doi.org\/10.1016\/j.jfda.2015.06.001","relation":{},"ISSN":["1021-9498"],"issn-type":[{"type":"print","value":"1021-9498"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and phototoxicity of isomeric 7,9-diglutathione pyrrole adducts: Formation of reactive oxygen species and induction of lipid peroxidation","name":"articletitle","label":"Article Title"},{"value":"Journal of Food and Drug Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfda.2015.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}