{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:21:38Z","timestamp":1780496498860,"version":"3.54.1"},"reference-count":50,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jfda-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food and Drug Analysis"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jfda.2017.11.004","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T04:44:33Z","timestamp":1513399473000},"page":"S78-S87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"S","title":["Association of antioxidant nutraceuticals and acetaminophen (paracetamol): Friend or foe?"],"prefix":"10.38212","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-2713","authenticated-orcid":false,"given":"Mohamed","family":"Abdel-Daim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman Ibrahim","family":"Abushouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Reggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagendra Sastry","family":"Yarla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Palmery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-5241","authenticated-orcid":false,"given":"Ilaria","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25385","reference":[{"key":"10.1016\/j.jfda.2017.11.004_bib1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.biopha.2017.04.033","article-title":"Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity","volume":"90","author":"Abushouk","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.jfda.2017.11.004_bib2","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1007\/s11356-014-3578-0","article-title":"Pharmacodynamic interaction of Spirulina platensis and deltamethrin in freshwater fish Nile tilapia, Oreochromis niloticus: impact on lipid peroxidation and oxidative stress","volume":"22","author":"Abdelkhalek","year":"2015","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.jfda.2017.11.004_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.semcancer.2016.02.001","article-title":"Targeting arachidonic acid pathway by natural products for cancer prevention and therapy","volume":"40\u201341","author":"Yarla","year":"2016","journal-title":"Semin Canc Biol"},{"issue":"14","key":"10.1016\/j.jfda.2017.11.004_bib4","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"Del Rio","year":"2013","journal-title":"Antioxidants Redox Signal"},{"issue":"9","key":"10.1016\/j.jfda.2017.11.004_bib5","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2174\/1389200216666151015113828","article-title":"Association of flavonoid-rich foods and statins in the management of hypercholesterolemia: a dangerous or helpful combination?","volume":"16","author":"Peluso","year":"2015","journal-title":"Curr Drug Metabol"},{"issue":"17\u201318","key":"10.1016\/j.jfda.2017.11.004_bib6","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.lfs.2011.01.025","article-title":"Current issues with acetaminophen hepatotoxicity\u2013a clinically relevant model to test the efficacy of natural products","volume":"88","author":"Jaeschke","year":"2011","journal-title":"Life Sci"},{"issue":"10","key":"10.1016\/j.jfda.2017.11.004_bib7","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.3109\/13880209.2016.1150302","article-title":"Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity","volume":"54","author":"Eugenio-Perez","year":"2016","journal-title":"Pharmaceut Biol"},{"issue":"3","key":"10.1016\/j.jfda.2017.11.004_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/bcp.12699","article-title":"Target biomarker profile for the clinical management of paracetamol overdose","volume":"80","author":"Vliegenthart","year":"2015","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jfda.2017.11.004_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.biopha.2015.02.028","article-title":"Flavonoids at the pharma-nutrition interface: is a therapeutic index in demand?","volume":"71","author":"Peluso","year":"2015","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.jfda.2017.11.004_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/03602532.2012.713969","article-title":"Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences","volume":"44","author":"Bousova","year":"2012","journal-title":"Drug Metab Rev"},{"issue":"9","key":"10.1016\/j.jfda.2017.11.004_bib11","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1007\/s11095-013-1007-6","article-title":"Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis","volume":"30","author":"McGill","year":"2013","journal-title":"Pharm Res"},{"key":"10.1016\/j.jfda.2017.11.004_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential","volume":"10","author":"Du","year":"2016","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1478-3231.2011.02501.x","article-title":"Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity","volume":"32","author":"Jaeschke","year":"2012","journal-title":"Liver Int"},{"issue":"5","key":"10.1016\/j.jfda.2017.11.004_bib14","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.fct.2012.01.027","article-title":"Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice","volume":"50","author":"Salminen","year":"2012","journal-title":"Food Chem Toxicol"},{"issue":"11","key":"10.1016\/j.jfda.2017.11.004_bib15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.phymed.2008.04.011","article-title":"Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury","volume":"15","author":"Hsu","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jfda.2017.11.004_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13020-015-0030-4","article-title":"Antioxidant effects of pineapple vinegar in reversing of paracetamol-induced liver damage in mice","volume":"10","author":"Mohamad","year":"2015","journal-title":"Chin Med"},{"issue":"4","key":"10.1016\/j.jfda.2017.11.004_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4103\/0974-8490.102274","article-title":"Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice","volume":"4","author":"Yamaura","year":"2012","journal-title":"Pharmacogn Res"},{"issue":"11","key":"10.1016\/j.jfda.2017.11.004_bib18","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1017\/S0007114509993758","article-title":"Protection by dietary Spirulina platensis against D-galactosamine\u2013and acetaminophen-induced liver injuries","volume":"103","author":"Lu","year":"2010","journal-title":"Br J Nutr"},{"issue":"15","key":"10.1016\/j.jfda.2017.11.004_bib19","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.3748\/wjg.15.1829","article-title":"Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression","volume":"15","author":"Chen","year":"2009","journal-title":"World J Gastroenterol"},{"issue":"11","key":"10.1016\/j.jfda.2017.11.004_bib20","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1007\/s10620-008-0239-5","article-title":"Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity","volume":"53","author":"Oz","year":"2008","journal-title":"Dig Dis Sci"},{"issue":"2","key":"10.1016\/j.jfda.2017.11.004_bib21","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3109\/01480545.2015.1070170","article-title":"Thearubigins protect against acetaminophen-induced hepatic and renal injury in mice: biochemical, histopathological, immunohistochemical, and flow cytometry study","volume":"39","author":"Murad","year":"2016","journal-title":"Drug Chem Toxicol"},{"issue":"6","key":"10.1016\/j.jfda.2017.11.004_bib22","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.3390\/molecules15064478","article-title":"In\u00a0vitro antioxidant activity and hepatoprotective effects of Lentinula edodes against paracetamol-induced hepatotoxicity","volume":"15","author":"Sasidharan","year":"2010","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.jfda.2017.11.004_bib23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2220\/biomedres.32.357","article-title":"Effects of kale ingestion on pharmacokinetics of acetaminophen in rats","volume":"32","author":"Yamasaki","year":"2011","journal-title":"Biomed Res"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/1872211309666151030110015","article-title":"The protective action of the aqueous extract of Auricularia polytricha in paracetamol induced hepatotoxicity in rats","volume":"10","author":"Chellappan","year":"2016","journal-title":"Recent Pat Drug Deliv Formulation"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5455\/jice.20160124113528","article-title":"Modulatory potentials of aqueous leaf and unripe fruit extracts of Carica papaya Linn. (Caricaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats","volume":"5","author":"Awodele","year":"2016","journal-title":"J Intercult Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.jfda.2017.11.004_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s13318-014-0251-4","article-title":"Evidence of reduced oral bioavailability of paracetamol in rats following multiple ingestion of grapefruit juice","volume":"41","author":"Qinna","year":"2016","journal-title":"Eur J Drug Metab Pharmacokinet"},{"issue":"3","key":"10.1016\/j.jfda.2017.11.004_bib27","first-page":"951","article-title":"Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity","volume":"28","author":"Vakiloddin","year":"2015","journal-title":"Pak J Pharm Sci"},{"key":"10.1016\/j.jfda.2017.11.004_bib28","doi-asserted-by":"crossref","first-page":"9470954","DOI":"10.1155\/2016\/9470954","article-title":"Satkara (Citrus macroptera) fruit protects against acetaminophen-induced hepatorenal toxicity in rats","volume":"2016","author":"Paul","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"issue":"10","key":"10.1016\/j.jfda.2017.11.004_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/nu8100607","article-title":"Hepatoprotective effect of Opuntia robusta and Opuntia streptacantha fruits against acetaminophen-induced acute liver damage","volume":"8","author":"Gonzalez-Ponce","year":"2016","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13105-013-0274-3","article-title":"Antioxidant and hepatoprotective potential of Pouteria campechiana on acetaminophen-induced hepatic toxicity in rats","volume":"70","author":"Aseervatham","year":"2014","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.jfda.2017.11.004_bib31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cbi.2016.10.009","article-title":"Caffeic acid attenuated acetaminophen-induced hepatotoxicity by inhibiting ERK1\/2-mediated early growth response-1 transcriptional activation","volume":"260","author":"Pang","year":"2016","journal-title":"Chem Biol Interact"},{"issue":"7","key":"10.1016\/j.jfda.2017.11.004_bib32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1631\/jzus.B1400346","article-title":"Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals","volume":"16","author":"Pang","year":"2015","journal-title":"J Zhejiang Univ - Sci B"},{"issue":"9","key":"10.1016\/j.jfda.2017.11.004_bib33","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1021\/acs.molpharmaceut.7b00345","article-title":"Eriodictyol, not its glucuronide metabolites, attenuates acetaminophen-induced hepatotoxicity","volume":"14","author":"Ye","year":"2017","journal-title":"Mol Pharm"},{"issue":"10","key":"10.1016\/j.jfda.2017.11.004_bib34","first-page":"4205","article-title":"Ferulic acid attenuated acetaminophen-induced hepatotoxicity though down-regulating the cytochrome P 2E1 and inhibiting toll-like receptor 4 signaling-mediated inflammation in mice","volume":"8","author":"Yuan","year":"2016","journal-title":"Am J Transl Res"},{"issue":"2","key":"10.1016\/j.jfda.2017.11.004_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1039\/C2FO30213F","article-title":"Protective effect of naringenin against acetaminophen-induced acute liver injury in metallothionein (MT)-null mice","volume":"4","author":"Lv","year":"2013","journal-title":"Food Funct"},{"issue":"11","key":"10.1016\/j.jfda.2017.11.004_bib36","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.3109\/03639045.2015.1008012","article-title":"Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in\u00a0vitro model: risk of liver toxicity","volume":"41","author":"Pingili","year":"2015","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.jfda.2017.11.004_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fct.2015.04.014","article-title":"Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity","volume":"81","author":"Du","year":"2015","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.hepres.2006.02.005","article-title":"Protective effects of resveratrol against acetaminophen-induced toxicity in mice","volume":"35","author":"Sener","year":"2006","journal-title":"Hepatol Res"},{"issue":"2","key":"10.1016\/j.jfda.2017.11.004_bib39","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.toxlet.2015.05.001","article-title":"Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways","volume":"236","author":"Wang","year":"2015","journal-title":"Toxicol Lett"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib40","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1080\/13880209.2017.1331248","article-title":"Effects of rosmarinic acid on acetaminophen-induced hepatotoxicity in male Wistar rats","volume":"55","author":"Hasanein","year":"2017","journal-title":"Pharmaceut Biol"},{"issue":"4","key":"10.1016\/j.jfda.2017.11.004_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1515\/JBCPP.2010.21.4.369","article-title":"Protective effects of syringic acid against acetaminophen-induced hepatic damage in albino rats","volume":"21","author":"Ramachandran","year":"2010","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"10.1016\/j.jfda.2017.11.004_bib42","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1186\/1472-6882-14-475","article-title":"An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects","volume":"14","author":"Evans","year":"2014","journal-title":"BMC Complement Altern Med"},{"issue":"6","key":"10.1016\/j.jfda.2017.11.004_bib43","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0009-9236(96)90213-1","article-title":"Decrease of plasma and urinary oxidative metabolites of acetaminophen after consumption of watercress by human volunteers","volume":"60","author":"Chen","year":"1996","journal-title":"Clin Pharmacol Therapeut"},{"issue":"2","key":"10.1016\/j.jfda.2017.11.004_bib44","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1365-2125.2012.04364.x","article-title":"Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers","volume":"75","author":"Volak","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jfda.2017.11.004_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1756-0500-2-45","article-title":"Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man","volume":"2","author":"Akerman","year":"2009","journal-title":"BMC Res Notes"},{"issue":"9","key":"10.1016\/j.jfda.2017.11.004_bib46","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1124\/dmd.111.039149","article-title":"UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables","volume":"39","author":"Navarro","year":"2011","journal-title":"Drug Metabol Dispos"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/03602532.2010.527984","article-title":"Paracetamol metabolism and related genetic differences","volume":"43","author":"Zhao","year":"2011","journal-title":"Drug Metab Rev"},{"issue":"1","key":"10.1016\/j.jfda.2017.11.004_bib48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13318-016-0329-2","article-title":"Characterizing the effects of race\/ethnicity on acetaminophen pharmacokinetics using physiologically based pharmacokinetic modeling","volume":"42","author":"Zurlinden","year":"2017","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.jfda.2017.11.004_bib49","doi-asserted-by":"crossref","first-page":"18563","DOI":"10.1038\/srep18563","article-title":"Gut bacterial diversity of the tribes of India and comparison with the worldwide data","volume":"5","author":"Dehingia","year":"2015","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jfda.2017.11.004_bib50","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/bdd.1799","article-title":"Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats","volume":"33","author":"Lee","year":"2012","journal-title":"Biopharm Drug Dispos"}],"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S102194981730203X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S102194981730203X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S102194981730203X?httpAccept=text\/plain","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T18:19:09Z","timestamp":1666635549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S102194981730203X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S102194981730203X"],"URL":"https:\/\/doi.org\/10.1016\/j.jfda.2017.11.004","relation":{},"ISSN":["1021-9498"],"issn-type":[{"value":"1021-9498","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of antioxidant nutraceuticals and acetaminophen (paracetamol): Friend or foe?","name":"articletitle","label":"Article Title"},{"value":"Journal of Food and Drug Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfda.2017.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}