{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:08:01Z","timestamp":1769220481632,"version":"3.49.0"},"reference-count":36,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST106-2320-B-008-005-MY3"],"award-info":[{"award-number":["MOST106-2320-B-008-005-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Central University-Landseed Hospital United Research Center","award":["NCU-LSH-105-A-006"],"award-info":[{"award-number":["NCU-LSH-105-A-006"]}]},{"name":"National Central University-Landseed Hospital United Research Center","award":["NCU-LSH-106-A-004"],"award-info":[{"award-number":["NCU-LSH-106-A-004"]}]}],"content-domain":{"domain":["jfda-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Food and Drug Analysis"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jfda.2018.09.008","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T06:10:15Z","timestamp":1540447815000},"page":"184-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-\u03b2, Wnt and STAT3 signaling pathways"],"prefix":"10.38212","volume":"27","author":[{"given":"In-Yu","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Shiou","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ching","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Yu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung-Tong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-Chang","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Che","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ssu-Ching","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Hsiung","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1800-2306","authenticated-orcid":false,"given":"Nianhan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"25385","reference":[{"key":"10.1016\/j.jfda.2018.09.008_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfda.2018.09.008_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00424-012-1209-5","article-title":"Hepatic stellate cells \u2013 the pericytes in the liver","volume":"465","author":"Hellerbrand","year":"2013","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jfda.2018.09.008_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jfda.2018.09.008_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-beta: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jfda.2018.09.008_bib5","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jfda.2018.09.008_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-kappaB and STAT3 \u2013 key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res"},{"key":"10.1016\/j.jfda.2018.09.008_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40659-015-0022-y","article-title":"Hepato-protective effect of rutin via IL-6\/STAT3 pathway in CCl4-induced hepatotoxicity in rats","volume":"48","author":"Hafez","year":"2015","journal-title":"Biol Res"},{"key":"10.1016\/j.jfda.2018.09.008_bib8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.jfda.2018.09.008_bib9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5009\/gnl.2014.8.3.282","article-title":"Mest attenuates CCl4-induced liver fibrosis in rats by inhibiting the Wnt\/beta-catenin signaling pathway","volume":"8","author":"Li","year":"2014","journal-title":"Gut Liver"},{"key":"10.1016\/j.jfda.2018.09.008_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2131\/jts.41.561","article-title":"Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis","volume":"41","author":"Dong","year":"2016","journal-title":"J Toxicol Sci"},{"key":"10.1016\/j.jfda.2018.09.008_bib11","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/labinvest.2010.123","article-title":"Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats","volume":"90","author":"Liu","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.jfda.2018.09.008_bib12","doi-asserted-by":"crossref","first-page":"212641","DOI":"10.1093\/ecam\/nep108","article-title":"Review of pharmacological effects of Antrodia camphorata and its bioactive compounds","volume":"2011","author":"Geethangili","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jfda.2018.09.008_bib13","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.3748\/wjg.v12.i15.2369","article-title":"Filtrate of fermented mycelia from Antrodia camphorata reduces liver fibrosis induced by carbon tetrachloride in rats","volume":"12","author":"Lin","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jfda.2018.09.008_bib14","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1021\/jf104561h","article-title":"Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol","volume":"59","author":"Wu","year":"2011","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jfda.2018.09.008_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.fct.2014.04.006","article-title":"Antrodia cinnamomea profoundly exalted the reversion of activated hepatic stellate cells by the alteration of cellular proteins","volume":"69","author":"Chen","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jfda.2018.09.008_bib16","doi-asserted-by":"crossref","first-page":"e0153087","DOI":"10.1371\/journal.pone.0153087","article-title":"Hepatoprotective effect of wheat-based solid-state fermented Antrodia cinnamomea in carbon tetrachloride-induced liver injury in rat","volume":"11","author":"Chiu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jfda.2018.09.008_bib17","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1038\/s41598-017-05072-y","article-title":"CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-kappaB pathways","volume":"7","author":"Lin","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jfda.2018.09.008_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfda.2018.09.008_bib19","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene Ontology Consortium: going forward","volume":"43","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jfda.2018.09.008_bib20","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jfda.2018.09.008_bib21","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1586\/egh.10.74","article-title":"The Wnt\/beta-catenin signaling pathway in liver biology and disease","volume":"4","author":"Behari","year":"2010","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jfda.2018.09.008_bib22","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3892\/mmr.2014.2099","article-title":"beta-catenin is overexpressed in hepatic fibrosis and blockage of Wnt\/beta-catenin signaling inhibits hepatic stellate cell activation","volume":"9","author":"Ge","year":"2014","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jfda.2018.09.008_bib23","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.bbadis.2014.07.025","article-title":"Stat3 signaling activation crosslinking of TGF-beta1 in hepatic stellate cell exacerbates liver injury and fibrosis","volume":"1842","author":"Xu","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jfda.2018.09.008_bib24","doi-asserted-by":"crossref","first-page":"536","DOI":"10.7150\/ijbs.7.536","article-title":"Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target","volume":"7","author":"Wang","year":"2011","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jfda.2018.09.008_bib25","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jfda.2018.09.008_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","article-title":"The role of TGFbeta1 in initiating hepatic stellate cell activation in\u00a0vivo","volume":"30","author":"Hellerbrand","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.jfda.2018.09.008_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/14756366.2016.1161620","article-title":"Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs","volume":"31","author":"Jablonska-Trypuc","year":"2016","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.jfda.2018.09.008_bib28","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/hep.510300432","article-title":"Matrix metalloproteinase-2 activation in human hepatic fibrosis regulation by cell\u2013matrix interactions","volume":"30","author":"Preaux","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jfda.2018.09.008_bib29","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.biochi.2013.09.003","article-title":"Wnt signaling in liver fibrosis: progress, challenges and potential directions","volume":"95","author":"Miao","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.jfda.2018.09.008_bib30","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1172\/JCI200317970","article-title":"Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms","volume":"112","author":"Haga","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfda.2018.09.008_bib31","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/mnfr.201500814","article-title":"Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFkappaB pro-inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet","volume":"60","author":"Li","year":"2016","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jfda.2018.09.008_bib32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fphys.2012.00069","article-title":"Cytokines and STATs in liver fibrosis","volume":"3","author":"Kong","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.jfda.2018.09.008_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fct.2015.01.012","article-title":"Antroquinonol from Antrodia camphorata suppresses breast tumor migration\/invasion through inhibiting ERK-AP-1- and AKT-NF-kappaB-dependent MMP-9 and epithelial-mesenchymal transition expressions","volume":"78","author":"Lee","year":"2015","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jfda.2018.09.008_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2016.04.004","article-title":"A semisynthetic diterpenoid lactone inhibits NF-kappaB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model","volume":"302","author":"Lim","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jfda.2018.09.008_bib35","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1021\/np070634k","article-title":"Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages","volume":"71","author":"Wu","year":"2008","journal-title":"J Nat Prod"},{"key":"10.1016\/j.jfda.2018.09.008_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jep.2010.07.057","article-title":"Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines","volume":"132","author":"Lee","year":"2010","journal-title":"J Ethnopharmacol"}],"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949818301625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949818301625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1021949818301625?httpAccept=text\/plain","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T18:19:46Z","timestamp":1666635586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1021949818301625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1021949818301625"],"URL":"https:\/\/doi.org\/10.1016\/j.jfda.2018.09.008","relation":{},"ISSN":["1021-9498"],"issn-type":[{"value":"1021-9498","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-\u03b2, Wnt and STAT3 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Food and Drug Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfda.2018.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}