{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:50:58Z","timestamp":1770324658747,"version":"3.49.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic and Legal Medicine"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.jflm.2006.11.004","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T07:17:49Z","timestamp":1174979869000},"page":"348-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro"],"prefix":"10.1016","volume":"14","author":[{"given":"Einosuke","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shinozuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jflm.2006.11.004_bib1","series-title":"Quick look drug book","first-page":"2","year":"2001"},{"key":"10.1016\/j.jflm.2006.11.004_bib2","unstructured":"National Research Institute of Police Science: annual case reports of drug and toxic poisoning in Japan (1990\u20132004), No. 33\u201347 [in Japanese]."},{"key":"10.1016\/j.jflm.2006.11.004_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jcfm.2005.02.002","article-title":"A study of the in vitro interaction between ethanol, and triazolam and its two metabolites using human liver microsomes","volume":"12","author":"Tanaka","year":"2005","journal-title":"J Clin Forensic Med"},{"key":"10.1016\/j.jflm.2006.11.004_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1742-7843.2005.pto960113.x","article-title":"Preliminary study of the in vitro interaction between alcohol, high-dose flunitrazepam and its three metabolites using human liver microsomes","volume":"96","author":"Tanaka","year":"2005","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.jflm.2006.11.004_bib5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/jat\/19.6.511","article-title":"High-performance liquid chromatography of alprazolam in postmortem blood using solid-phase extraction","volume":"19","author":"Hall","year":"1995","journal-title":"J Anal Toxicol"},{"key":"10.1016\/j.jflm.2006.11.004_bib6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/jat\/21.3.218","article-title":"A fatality due to alprazolam intoxication","volume":"21","author":"Jenkins","year":"1997","journal-title":"J Anal Toxicol"},{"key":"10.1016\/j.jflm.2006.11.004_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0379-0738(99)00118-8","article-title":"Fatal overdose of tramadol and alprazolam","volume":"105","author":"Michaud","year":"1999","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jflm.2006.11.004_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.forsciint.2004.10.025","article-title":"Identification of alprazolam in hair in two cases of drug-facilitated incidents","volume":"53","author":"Kintz","year":"2005","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jflm.2006.11.004_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0379-0738(01)00483-2","article-title":"Drug and chemical blood-level data 2001","volume":"122","author":"Winek","year":"2001","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jflm.2006.11.004_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00228-004-0861-x","article-title":"Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects","volume":"61","author":"Wennerholm","year":"2005","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jflm.2006.11.004_bib11","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1124\/dmd.104.000844","article-title":"Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates","volume":"32","author":"Galetin","year":"2004","journal-title":"Drug Metab Dispo"},{"key":"10.1016\/j.jflm.2006.11.004_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02439595","article-title":"Influence of dosing regimen on alprazolam and metabolite serum concentrations and tolerance to sedative and psychomotor effects","volume":"93","author":"Smith","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jflm.2006.11.004_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00004714-199504000-00008","article-title":"Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants","volume":"15","author":"von Moltke","year":"1995","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.jflm.2006.11.004_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/01.jcp.0000085407.08426.e1","article-title":"Pharmacokinetic and pharmacodynamic evaluation of the inhibition of alprazolam by citalopram and fluoxetine","volume":"23","author":"Hall","year":"2003","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.jflm.2006.11.004_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3109\/15563659409017974","article-title":"Mechanisms of ethanol\u2013drug\u2013nutrition interactions","volume":"32","author":"Lieber","year":"1994","journal-title":"J Toxicol Clin Toxicol"},{"key":"10.1016\/j.jflm.2006.11.004_bib16","first-page":"315","article-title":"Susceptibility to alcohol-related liver injury","volume":"2","author":"Lieber","year":"1994","journal-title":"Alcohol Alcoholism"},{"key":"10.1016\/j.jflm.2006.11.004_bib17","first-page":"82A","article-title":"Ethanol and acetaldehyde metabolism: past, present, and future","volume":"20","author":"Kitson","year":"1995","journal-title":"Alcohol Clinical Exp Res"},{"key":"10.1016\/j.jflm.2006.11.004_bib18","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0022-3565(25)12886-3","article-title":"Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450\u2019s","volume":"277","author":"Asai","year":"1996","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.jflm.2006.11.004_bib19","doi-asserted-by":"crossref","first-page":"138A","DOI":"10.1111\/j.1530-0277.1996.tb01764.x","article-title":"Ethanol-inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance: 1996 up-date","volume":"20","author":"Song","year":"1996","journal-title":"Alcohol Clinical Exp Res"},{"key":"10.1016\/j.jflm.2006.11.004_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF02657051","article-title":"Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers","volume":"39","author":"Linnoila","year":"1990","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jflm.2006.11.004_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0379-0738(99)00118-8","article-title":"Fatal overdose of tramadol and alprazolam","volume":"105","author":"Michaud","year":"1999","journal-title":"Forensic Sci Int"}],"container-title":["Journal of Forensic and Legal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1752928X06002733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1752928X06002733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:01:58Z","timestamp":1761696118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1752928X06002733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S1752928X06002733"],"URL":"https:\/\/doi.org\/10.1016\/j.jflm.2006.11.004","relation":{},"ISSN":["1752-928X"],"issn-type":[{"value":"1752-928X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Forensic and Legal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jflm.2006.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd and FFLM. All rights reserved.","name":"copyright","label":"Copyright"}]}}