{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:11:13Z","timestamp":1769130673950,"version":"3.49.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K10564"],"award-info":[{"award-number":["20K10564"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10620"],"award-info":[{"award-number":["22K10620"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic and Legal Medicine"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jflm.2023.102516","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T12:00:31Z","timestamp":1680004831000},"page":"102516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Relationships between cause of death and concentrations of seven steroids obtained from the serum and cerebrospinal fluid of cadavers"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4732-5577","authenticated-orcid":false,"given":"Tadashi","family":"Nishio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Toukairin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-8455","authenticated-orcid":false,"given":"Makoto","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jflm.2023.102516_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105439","article-title":"Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review","volume":"194","author":"Schiffer","year":"2019","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jflm.2023.102516_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chroma.2015.07.008","article-title":"Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbations","volume":"1430","author":"Jeanneret","year":"2015","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.jflm.2023.102516_bib3","series-title":"Steroid Hormone Regulation of the Brain","first-page":"3","article-title":"Steroid hormones in the brain: several mechanisms?","author":"Baulieu","year":"1981"},{"key":"10.1016\/j.jflm.2023.102516_bib4","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1096\/fasebj.6.6.1347506","article-title":"Neuroactive steroids","volume":"6","author":"Paul","year":"1992","journal-title":"Faseb J"},{"key":"10.1016\/j.jflm.2023.102516_bib5","article-title":"Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: sex-specific features","author":"Melcangi","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jflm.2023.102516_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2020.105753","article-title":"Determination of neurosteroids in human cerebrospinal fluid in the 21st century: a review","volume":"204","author":"Teubel","year":"2020","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jflm.2023.102516_bib7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.forsciint.2013.03.003","article-title":"Glucocorticosteroids as markers of death from hypothermia","volume":"229","author":"Ba\u0144ka","year":"2013","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.jflm.2023.102516_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218910","article-title":"Cortisol levels after cold exposure are independent of adrenocorticotropic hormone stimulation","volume":"15","author":"Shida","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jflm.2023.102516_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1749-6632.2003.tb03143.x","article-title":"The hypothalamo-pituitary-adrenal axis in multiple sclerosis","volume":"992","author":"Huitinga","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jflm.2023.102516_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/sj.npp.1300299","article-title":"Stress of dying is not suppressed by high-dose morphine or by dementia","volume":"29","author":"Erkut","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jflm.2023.102516_bib11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/00313020701716466","article-title":"Hypothermia fatalities in a temperate climate: sydney, Australia","volume":"40","author":"Lim","year":"2008","journal-title":"Pathology"},{"key":"10.1016\/j.jflm.2023.102516_bib12","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1038\/npp.2014.138","article-title":"A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression","volume":"39","author":"Brown","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jflm.2023.102516_bib13","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jpba.2007.03.007","article-title":"Development and application of electrospray-active derivatization reagents for hydroxysteroids","volume":"44","author":"Nishio","year":"2007","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.jflm.2023.102516_bib14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1248\/cpb.55.662","article-title":"Alternative procedure for charged derivatization to enhance detection responses of steroids in electrospray ionization-MS","volume":"55","author":"Higashi","year":"2007","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.jflm.2023.102516_bib15","unstructured":"ICH guideline M10 on bioanalytical method validation and study sample analysis, European medicines agency. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/ich-guideline-m10-bioanalytical-method-validation-step-5_en.pdf."},{"key":"10.1016\/j.jflm.2023.102516_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jsbmb.2013.06.014","article-title":"Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization\/selected reaction monitoring\/mass spectrometry (SID-LC\/ESI\/SRM\/MS) method for quantification of keto-androgens in human serum","volume":"138","author":"Tamae","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jflm.2023.102516_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jsbmb.2015.10.003","article-title":"Chemical derivatization for enhancing sensitivity during LC\/ESI-MS\/MS quantification of steroids in biological samples: a review","volume":"162","author":"Higashi","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jflm.2023.102516_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2020.105797","article-title":"From a single steroid to the steroidome: trends and analytical challenges","volume":"206","author":"Olesti","year":"2021","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jflm.2023.102516_bib19","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3390\/biom11111573","article-title":"Glucocorticoid\/Adiponectin axis mediates full activation of cold-induced beige fat thermogenesis","volume":"11","author":"Luo","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jflm.2023.102516_bib20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.legalmed.2015.08.004","article-title":"Comprehensive investigation of postmortem glucose levels in blood and body fluids with regard to the cause of death in forensic autopsy cases","volume":"17","author":"Chen","year":"2015","journal-title":"Leg Med"},{"key":"10.1016\/j.jflm.2023.102516_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.legalmed.2021.101908","article-title":"Hyperketonemia as the diagnostic basis for hypothermia: an experimental study in diabetic and control mice","volume":"52","author":"Nogami","year":"2021","journal-title":"Leg Med"},{"key":"10.1016\/j.jflm.2023.102516_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jsbmb.2014.09.001","article-title":"Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection","volume":"146","author":"Guennoun","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jflm.2023.102516_bib23","article-title":"Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease","volume":"12","author":"Boero","year":"2019","journal-title":"Neurobiol. Stress"}],"container-title":["Journal of Forensic and Legal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1752928X23000343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1752928X23000343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:17:39Z","timestamp":1761697059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1752928X23000343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":23,"alternative-id":["S1752928X23000343"],"URL":"https:\/\/doi.org\/10.1016\/j.jflm.2023.102516","relation":{},"ISSN":["1752-928X"],"issn-type":[{"value":"1752-928X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationships between cause of death and concentrations of seven steroids obtained from the serum and cerebrospinal fluid of cadavers","name":"articletitle","label":"Article Title"},{"value":"Journal of Forensic and Legal Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jflm.2023.102516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102516"}}