{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:23:59Z","timestamp":1771881839719,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"vor","delay-in-days":1000,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 98-2314-B-002-090-MY3"],"award-info":[{"award-number":["NSC 98-2314-B-002-090-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.jfma.2012.04.009","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T03:30:33Z","timestamp":1343964633000},"page":"253-258","source":"Crossref","is-referenced-by-count":7,"title":["Increased placenta growth factor mRNA level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma"],"prefix":"10.1016","volume":"112","author":[{"given":"Shih-Jung","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Lung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang-Jaer","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Hueng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Heng","family":"Kok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng Ling","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Yen-Ping","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2012.04.009_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tripleo.2005.07.038","article-title":"Oral squamous cell carcinoma: review of prognostic and predictive factors","volume":"102","author":"Massano","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jfma.2012.04.009_bib2","series-title":"Cancer registry annual report in Taiwan area, 2010","year":"2011"},{"key":"10.1016\/j.jfma.2012.04.009_bib3","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nrc2524","article-title":"FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?","volume":"8","author":"Fischer","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jfma.2012.04.009_bib4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2353\/ajpath.2006.051041","article-title":"Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor","volume":"169","author":"Marcellini","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jfma.2012.04.009_bib5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1046\/j.1523-1747.2000.00199.x","article-title":"Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor","volume":"115","author":"Lacal","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jfma.2012.04.009_bib6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-0609.2005.00505.x","article-title":"Placenta growth factor stimulates the growth of Philadelphia chromosome positive acute lymphoblastic leukemia cells by both autocrine and paracrine pathways","volume":"75","author":"Ikai","year":"2005","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jfma.2012.04.009_bib7","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/j.ejca.2005.07.022","article-title":"Placenta growth factor is over-expressed and has prognostic value in human breast cancer","volume":"41","author":"Parr","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jfma.2012.04.009_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.canlet.2004.05.020","article-title":"The significance of placenta growth factor in angiogenesis and clinical outcome of human gastric cancer","volume":"213","author":"Chen","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jfma.2012.04.009_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1477-7819-3-68","article-title":"Expression of placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance","volume":"3","author":"Zhang","year":"2005","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.jfma.2012.04.009_bib10","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/gut.2004.050831","article-title":"Placenta growth factor expression is correlated with survival of patients with colorectal cancer","volume":"54","author":"Wei","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jfma.2012.04.009_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.canlet.2006.10.005","article-title":"Placenta growth factor not vascular endothelial growth factor A or C can predict the early recurrence after radical resection of hepatocellular carcinoma","volume":"250","author":"Ho","year":"2007","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jfma.2012.04.009_bib12","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/hed.21335","article-title":"Expression of placenta growth factor: an independent factor for prediction of progression and prognosis of oral cancer","volume":"32","author":"Cheng","year":"2010","journal-title":"Head Neck"},{"key":"10.1016\/j.jfma.2012.04.009_bib13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.oraloncology.2011.12.007","article-title":"Increased serum placenta growth factor level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma","volume":"48","author":"Cheng","year":"2012","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jfma.2012.04.009_bib14","series-title":"TNM classification of malignant tumours","first-page":"19","year":"2002"},{"key":"10.1016\/j.jfma.2012.04.009_bib15","first-page":"4233","article-title":"Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis","volume":"54","author":"Takahashi","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.jfma.2012.04.009_bib16","first-page":"508","article-title":"Placenta growth factor is abundantly expressed in human cervical squamous cell carcinoma","volume":"18","author":"Kodama","year":"1997","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.jfma.2012.04.009_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2012.04.009_bib18","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placenta growth factor: potentiation of vascular endothelial growth factor bioactivity, in\u00a0vitro and in\u00a0vivo, and high affinity binding to Flt-1 but not to Flk-1\/KDR","volume":"269","author":"Park","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfma.2012.04.009_bib19","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1182\/blood-2002-11-3423","article-title":"Mechanisms of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor","volume":"102","author":"Selvaraj","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2012.04.009_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jcb.21831","article-title":"Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1","volume":"105","author":"Chen","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jfma.2012.04.009_bib21","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1158\/1535-7163.MCT-06-0461","article-title":"Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF\/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts","volume":"6","author":"Taylor","year":"2007","journal-title":"Mol Cancer Ther"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966461200277X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966461200277X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T09:22:05Z","timestamp":1643102525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092966461200277X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S092966461200277X"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2012.04.009","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}