{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:58:07Z","timestamp":1790258287545,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 100-2221-E-182-056-MY3"],"award-info":[{"award-number":["MOST 100-2221-E-182-056-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 103-2221-E-182-022"],"award-info":[{"award-number":["MOST 103-2221-E-182-022"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","jfma-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.jfma.2015.01.015","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T13:45:31Z","timestamp":1425649531000},"page":"456-463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influenza A virus plasticity\u2014A temporal analysis of species-associated genomic signatures"],"prefix":"10.1016","volume":"114","author":[{"given":"Guang-Wu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Nong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ru","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2015.01.015_bib1","unstructured":"World Health Organization. Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO (as of 24 January 2014). Available at: http:\/\/www.who.int\/influenza\/human_animal_interface\/EN_GIP_20140124CumulativeNumberH5N1cases.pdf?ua=1 [accessed 30.09.14]."},{"key":"10.1016\/j.jfma.2015.01.015_bib2","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1304459","article-title":"Human infection with a novel avian-origin influenza A (H7N9) virus","volume":"368","author":"Gao","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2015.01.015_bib3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jfma.2013.04.015","article-title":"Is avian influenza A (H7N9) virus staggering its way to humans?","volume":"112","author":"Chen","year":"2013","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jfma.2015.01.015_bib4","article-title":"Final analysis of Netherlands avian influenza outbreaks reveals much higher levels of transmission to humans than previously thought","volume":"10","author":"Bosman","year":"2005","journal-title":"Euro Surveill"},{"key":"10.1016\/j.jfma.2015.01.015_bib5","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.96.16.9363","article-title":"Molecular characterization of H9N2 influenza viruses: were they the donors of the \u201cinternal\u201d genes of H5N1 viruses in Hong Kong?","volume":"96","author":"Guan","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfma.2015.01.015_bib6","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1128\/JVI.67.4.1761-1764.1993","article-title":"A single amino acid in the PB2 gene of influenza A virus is a determinant of host range","volume":"67","author":"Subbarao","year":"1993","journal-title":"J Virol"},{"key":"10.1016\/j.jfma.2015.01.015_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.virol.2003.11.030","article-title":"PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice","volume":"320","author":"Shinya","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jfma.2015.01.015_bib8","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3201\/eid1209.060276","article-title":"Genomic signatures of human versus avian influenza A viruses","volume":"12","author":"Chen","year":"2006","journal-title":"Emerging Infect Dis"},{"key":"10.1016\/j.jfma.2015.01.015_bib9","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.3201\/eid1512.090845","article-title":"Genomic signatures of influenza A pandemic (H1N1) 2009 virus","volume":"15","author":"Chen","year":"2009","journal-title":"Emerging Infect Dis"},{"key":"10.1016\/j.jfma.2015.01.015_bib10","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1099\/vir.0.031492-0","article-title":"Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase","volume":"92","author":"Foeglein","year":"2011","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jfma.2015.01.015_bib11","doi-asserted-by":"crossref","first-page":"10439","DOI":"10.1074\/jbc.M110.182964","article-title":"Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly","volume":"286","author":"Boivin","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfma.2015.01.015_bib12","first-page":"400","article-title":"Swine influenza A (H1N1) infection in two children\u2014Southern California, March\u2013April 2009","volume":"58","author":"Centers for Disease Control and Prevention (CDC)","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jfma.2015.01.015_bib13","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3201\/eid1512.091413","article-title":"Estimates of the prevalence of pandemic (H1N1) 2009, United States, April\u2013July 2009","volume":"15","author":"Reed","year":"2009","journal-title":"Emerging Infect Dis"},{"key":"10.1016\/j.jfma.2015.01.015_bib14","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1189132","article-title":"Reassortment of pandemic H1N1\/2009 influenza A virus in swine","volume":"328","author":"Vijaykrishna","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jfma.2015.01.015_bib15","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature08182","article-title":"Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic","volume":"459","author":"Smith","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2015.01.015_bib16","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1128\/JVI.02005-07","article-title":"The influenza virus resource at the National Center for Biotechnology Information","volume":"82","author":"Bao","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.jfma.2015.01.015_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European Molecular Biology Open Software Suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet"},{"key":"10.1016\/j.jfma.2015.01.015_bib18","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664615000662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664615000662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T15:45:03Z","timestamp":1598802303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664615000662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0929664615000662"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2015.01.015","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influenza A virus plasticity\u2014A temporal analysis of species-associated genomic signatures","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2015.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier (Singapore) Pte Ltd.","name":"copyright","label":"Copyright"}]}}