{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T19:30:32Z","timestamp":1747164632673,"version":"3.40.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,14]],"date-time":"2017-01-14T00:00:00Z","timestamp":1484352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","jfma-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jfma.2017.03.013","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T21:46:30Z","timestamp":1492465590000},"page":"191-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between monocyte chemoattractant protein-1 -2518 A\/G gene polymorphism and the outcome of the nonsurgical periodontal treatment"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-900X","authenticated-orcid":false,"given":"Ching-Wen","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Yun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2004-4874","authenticated-orcid":false,"given":"Ching-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Ling","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2017.03.013_bib1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2017.03.013_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jfma.2017.03.013_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.18.1.217","article-title":"The biology of chemokines and their receptors","volume":"18","author":"Rossi","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jfma.2017.03.013_bib4","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1128\/IAI.61.11.4622-4628.1993","article-title":"Expression of monocyte chemoattractant protein 1 in human inflamed gingival tissues","volume":"61","author":"Yu","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.jfma.2017.03.013_bib5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1600-051X.2004.00584.x","article-title":"Gingival crevicular fluid monocyte chemoattractant protein-1 and RANTES levels in patients with generalized aggressive periodontitis","volume":"31","author":"Emingil","year":"2004","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib6","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1902\/jop.2005.76.11.1849","article-title":"Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis","volume":"76","author":"Kurtis","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.archoralbio.2009.02.007","article-title":"Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in periodontal health and disease","volume":"54","author":"Pradeep","year":"2009","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jfma.2017.03.013_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cyto.2009.05.012","article-title":"Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease","volume":"47","author":"Pradeep","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.jfma.2017.03.013_bib9","first-page":"12","article-title":"Smoking is a major risk factor for periodontitis","volume":"3","author":"Haber","year":"1994","journal-title":"Curr Opin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib10","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1902\/jop.2013.120666","article-title":"Increased levels of serum and gingival crevicular fluid monocyte chemoattractant protein-1 in smokers with periodontitis","volume":"84","author":"Anil","year":"2013","journal-title":"J Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-051X.2010.01684.x","article-title":"Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis","volume":"38","author":"Tymkiw","year":"2011","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib12","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00784-014-1314-2","article-title":"Impact of periodontitis on chemokines in smokers","volume":"19","author":"Haytural","year":"2015","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.jfma.2017.03.013_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/08916930310001609446","article-title":"The MCP-1 promoter-2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients","volume":"37","author":"Cho","year":"2004","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jfma.2017.03.013_bib14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1006\/bbrc.1999.0796","article-title":"A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression","volume":"259","author":"Rovin","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jfma.2017.03.013_bib15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1089\/gtmb.2013.0318","article-title":"MCP-1-2518A>G polymorphism and myocardial infarction risk: a meta-analysis and meta-regression","volume":"17","author":"Mao","year":"2013","journal-title":"Genet Test Mol Biomark"},{"key":"10.1016\/j.jfma.2017.03.013_bib16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/dna.2013.2263","article-title":"Correlations of MCP-1-2518A>G polymorphism and serum levels with cerebral infarction risk: a meta-analysis","volume":"33","author":"Gao","year":"2014","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.jfma.2017.03.013_bib17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-0765.2011.01426.x","article-title":"Association analysis between the -2518MCP-1(A\/G) polymorphism and generalized aggressive periodontitis in a Chinese population","volume":"47","author":"Zhu","year":"2012","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jfma.2017.03.013_bib18","first-page":"109","article-title":"Combined association of CCR2-V64I and MCP-1-2518A\/G polymorphisms with generalised aggressive periodontitis in Chinese","volume":"13","author":"Zhu","year":"2010","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.jfma.2017.03.013_bib19","first-page":"766","article-title":"Non-surgical therapy","volume":"vol. 2","author":"Claffey","year":"2008"},{"key":"10.1016\/j.jfma.2017.03.013_bib20","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo","year":"1975","journal-title":"Int Dent J"},{"key":"10.1016\/j.jfma.2017.03.013_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","article-title":"The plaque control record","volume":"43","author":"O'Leary","year":"1972","journal-title":"J Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib23","first-page":"1","article-title":"Does vaping in E-cigarette advertisements affect tobacco smoking urge, intentions, and perceptions in daily, intermittent, and former smokers?","volume":"11","author":"Maloney","year":"2015","journal-title":"Health Commun"},{"key":"10.1016\/j.jfma.2017.03.013_bib24","first-page":"29","article-title":"MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma","volume":"12","author":"Dhaouadi","year":"2013","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"10.1016\/j.jfma.2017.03.013_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/jre.12181","article-title":"Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities","volume":"50","author":"Wu","year":"2015","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jfma.2017.03.013_bib26","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1093\/ndt\/gfr105","article-title":"Polymorphism of proinflammatory cytokine genes and albuminuria in the Japanese general population: the Takahata study","volume":"26","author":"Mashima","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jfma.2017.03.013_bib27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2370.2002.00346.x","article-title":"Allelic frequency of the MCP-1 promoter -2518 polymorphism in the Korean population and in Korean patients with rheumatoid arthritis, systemic lupus erythematosus and adult-onset Still's disease","volume":"29","author":"Hwang","year":"2002","journal-title":"Eur J Immunogenet"},{"key":"10.1016\/j.jfma.2017.03.013_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9150(01)00423-3","article-title":"Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1-2518 G\/G genotype in CAD patients","volume":"158","author":"Szalai","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jfma.2017.03.013_bib29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1034\/j.1399-0039.2001.580508.x","article-title":"MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus","volume":"58","author":"Aguilar","year":"2001","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jfma.2017.03.013_bib30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-051X.2007.01055.x","article-title":"The association of the composite IL-1 genotype with periodontitis progression and\/or treatment outcomes: a systematic review","volume":"34","author":"Huynh-Ba","year":"2007","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib31","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1600-051X.1999.tb02525.x","article-title":"Interleukin-1 haplotype and periodontal disease progression following therapy","volume":"26","author":"Ehmke","year":"1999","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1034\/j.1600-0765.2000.035002102.x","article-title":"Effect of interleukin-1 gene polymorphisms on gingival inflammation assessed by bleeding on probing in a periodontal maintenance population","volume":"35","author":"Lang","year":"2000","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.jfma.2017.03.013_bib33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1902\/jop.1999.70.1.49","article-title":"Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL-1 genotype in accurately predicting prognoses and tooth survival","volume":"70","author":"McGuire","year":"1999","journal-title":"J Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.archoralbio.2012.01.016","article-title":"Interleukin-1 receptor antagonist polymorphism (rs2234663) and periodontitis susceptibility: a meta-analysis","volume":"57","author":"Ding","year":"2012","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.jfma.2017.03.013_bib35","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1631\/jzus.B0920279","article-title":"Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis","volume":"10","author":"Shao","year":"2009","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.jfma.2017.03.013_bib36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-051X.2009.01530.x","article-title":"Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis","volume":"37","author":"Dimou","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1600-051X.2009.01370.x","article-title":"TLR4 as a risk factor for periodontal disease: a reappraisal","volume":"36","author":"Ozturk","year":"2009","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.ebd.6400326","article-title":"Smokers have less reductions in probing depth than non-smokers following nonsurgical periodontal therapy","volume":"6","author":"Garcia","year":"2005","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.jfma.2017.03.013_bib39","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1600-051X.2010.01541.x","article-title":"Age-related treatment response following non-surgical periodontal therapy","volume":"37","author":"Trombelli","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.jfma.2017.03.013_bib40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/idh.12032","article-title":"Outcomes of non-surgical periodontal treatment by dental hygienists in training: impact of site- and patient-level factors","volume":"11","author":"Preshaw","year":"2013","journal-title":"Int J Dent Hyg"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664617300219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664617300219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T16:42:12Z","timestamp":1601916132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664617300219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0929664617300219"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2017.03.013","relation":{},"ISSN":["0929-6646"],"issn-type":[{"type":"print","value":"0929-6646"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between monocyte chemoattractant protein-1 -2518 A\/G gene polymorphism and the outcome of the nonsurgical periodontal treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2017.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}