{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:46:20Z","timestamp":1791600380259,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology, Republic of China","award":["95-2320-B-002-107-MY3"],"award-info":[{"award-number":["95-2320-B-002-107-MY3"]}]},{"name":"Ministry of Science and Technology, Republic of China","award":["98-2320-B-002-051-MY3"],"award-info":[{"award-number":["98-2320-B-002-051-MY3"]}]},{"name":"Ministry of Science and Technology, Republic of China","award":["103-2320-B-002-040-MY3"],"award-info":[{"award-number":["103-2320-B-002-040-MY3"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","jfma-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jfma.2017.05.002","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T20:31:53Z","timestamp":1495571513000},"page":"471-479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single allele Lmbrd1 knockout results in cardiac hypertrophy"],"prefix":"10.1016","volume":"117","author":[{"given":"Linda Tzu-Ling","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Liang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Hsiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Yuan","family":"Tzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jai","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ti","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-7852","authenticated-orcid":false,"given":"Pai-Chi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Tien","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin C.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Fu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2017.05.002_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jfma.2017.05.002_bib2","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfma.2017.05.002_bib3","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","article-title":"Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2017.05.002_bib4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1172\/JCI27374","article-title":"Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling","volume":"116","author":"Wu","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfma.2017.05.002_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","article-title":"Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy","volume":"110","author":"Zhang","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jfma.2017.05.002_bib6","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI38022","article-title":"Requirement for Ca2+\/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice","volume":"119","author":"Ling","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfma.2017.05.002_bib7","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","article-title":"Rapamycin attenuates load-induced cardiac hypertrophy in mice","volume":"107","author":"Shioi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2017.05.002_bib8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0950-351X(05)80241-1","article-title":"Cardiovascular actions of insulin in humans. Implications for insulin sensitivity and vascular tone","volume":"7","author":"Baron","year":"1993","journal-title":"Baillieres Clin Endocrinol Metab"},{"key":"10.1016\/j.jfma.2017.05.002_bib9","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1172\/JCI40096","article-title":"Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents","volume":"120","author":"Shimizu","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfma.2017.05.002_bib10","doi-asserted-by":"crossref","first-page":"II187","DOI":"10.1161\/01.CIR.100.suppl_2.II-187","article-title":"Impaired glucose transporter activity in pressure-overload hypertrophy is an early indicator of progression to failure","volume":"100","author":"Friehs","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2017.05.002_bib11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1172\/JCI0213946","article-title":"Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression","volume":"109","author":"Belke","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfma.2017.05.002_bib12","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1128\/MCB.01110-06","article-title":"Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function","volume":"27","author":"Laustsen","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jfma.2017.05.002_bib13","doi-asserted-by":"crossref","first-page":"32424","DOI":"10.1074\/jbc.M113.479527","article-title":"LMBD1 protein serves as a specific adaptor for insulin receptor internalization","volume":"288","author":"Tseng","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfma.2017.05.002_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/00016480802593497","article-title":"An animal model of central auditory pathway imaging in the rat brain by high resolution small animal positron emission tomography","volume":"129","author":"Hsu","year":"2009","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jfma.2017.05.002_bib15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00259-004-1628-4","article-title":"ECG-triggered high-resolution positron emission tomography: a breakthrough in cardiac molecular imaging of mice","volume":"32","author":"Schafers","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jfma.2017.05.002_bib16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2967\/jnumed.108.056051","article-title":"Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI","volume":"50","author":"Stegger","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jfma.2017.05.002_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/016173460803000402","article-title":"Characterization of malignant focal liver lesions with contrast-enhanced 40 MHz ultrasound imaging in hepatitis B virus X transgenic mice: a feasibility study","volume":"30","author":"Liao","year":"2008","journal-title":"Ultrason Imaging"},{"key":"10.1016\/j.jfma.2017.05.002_bib18","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1172\/JCI43569","article-title":"Proapoptotic Rassf1A\/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice","volume":"120","author":"Del Re","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfma.2017.05.002_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1210\/er.2007-0006","article-title":"Cardiovascular actions of insulin","volume":"28","author":"Muniyappa","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jfma.2017.05.002_bib20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11906-004-0034-4","article-title":"Insulin signaling in heart muscle: lessons from genetically engineered mouse models","volume":"6","author":"Abel","year":"2004","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.jfma.2017.05.002_bib21","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.yjmcc.2008.03.008","article-title":"Insulin signaling pathways and cardiac growth","volume":"44","author":"DeBosch","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jfma.2017.05.002_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/ng.294","article-title":"Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism","volume":"41","author":"Rutsch","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jfma.2017.05.002_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jcp.19.1.51","article-title":"Plasma lactate dehydrogenase in megaloblastic anaemia","volume":"19","author":"McCarthy","year":"1966","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jfma.2017.05.002_bib24","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","article-title":"Akt induces enhanced myocardial contractility and cell size in\u00a0vivo in transgenic mice","volume":"99","author":"Condorelli","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfma.2017.05.002_bib25","doi-asserted-by":"crossref","first-page":"22896","DOI":"10.1074\/jbc.M200347200","article-title":"Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart","volume":"277","author":"Matsui","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfma.2017.05.002_bib26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1015332726303","article-title":"Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth","volume":"7","author":"Lehman","year":"2002","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jfma.2017.05.002_bib27","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nature06798","article-title":"Tackling heart failure in the twenty-first century","volume":"451","author":"Mudd","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2017.05.002_bib28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1196\/annals.1341.019","article-title":"Metabolic energetics and genetics in the heart","volume":"1047","author":"Taegtmeyer","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jfma.2017.05.002_bib29","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/nm1116","article-title":"Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy","volume":"10","author":"Cheng","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.jfma.2017.05.002_bib30","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1172\/JCI9056","article-title":"Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth","volume":"105","author":"Barger","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jfma.2017.05.002_bib31","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.jacc.2006.07.026","article-title":"Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies","volume":"48","author":"Barth","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2017.05.002_bib32","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1111\/jcmm.12844","article-title":"Lmbrd1 expression is essential for the initiation of gastrulation","volume":"20","author":"Buers","year":"2016","journal-title":"J Cell Mol Med"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664616303552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664616303552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T10:21:51Z","timestamp":1535797311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664616303552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0929664616303552"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2017.05.002","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single allele Lmbrd1 knockout results in cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2017.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}