{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:25:09Z","timestamp":1790270709621,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Taiwan Children Liver Foundation"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","jfma-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jfma.2017.05.008","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T07:00:45Z","timestamp":1496386845000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Modality of treatment and potential outcome of Wilson disease in Taiwan: A population-based longitudinal study"],"prefix":"10.1016","volume":"117","author":[{"given":"Chi-San","family":"Tai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huey-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hwei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hsuan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2017.05.008_bib1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ng1293-344","article-title":"The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene","volume":"5","author":"Tanzi","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.jfma.2017.05.008_bib2","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.4254\/wjh.v7.i29.2859","article-title":"Wilson's disease: a review of what we have learned","volume":"7","author":"Rodriguez-Castro","year":"2015","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jfma.2017.05.008_bib3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ejmg.2014.04.016","article-title":"New mutations and polymorphisms of the ATP7B gene in sporadic Wilson disease","volume":"57","author":"Lu","year":"2014","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.jfma.2017.05.008_bib4","first-page":"671","article-title":"Wilson's disease","volume":"56","author":"EASL Clinical Practice Guidelines","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.jfma.2017.05.008_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bpg.2010.07.014","article-title":"Wilson disease","volume":"24","author":"Huster","year":"2010","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jfma.2017.05.008_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1468-1331.2009.02946.x","article-title":"Population-based epidemiologic study of Wilson's disease in Taiwan","volume":"17","author":"Lai","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jfma.2017.05.008_bib7","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cgh.2013.03.012","article-title":"Efficacy and safety of oral chelators in treatment of patients with Wilson disease","volume":"11","author":"Weiss","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jfma.2017.05.008_bib8","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/hep.22261","article-title":"Diagnosis and treatment of Wilson disease: an update","volume":"47","author":"Roberts","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jfma.2017.05.008_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000115077","article-title":"Oral zinc sulphate as long-term treatment in Wilson's disease (hepatolenticular degeneration)","volume":"18","author":"Hoogenraad","year":"1979","journal-title":"Eur Neurol"},{"key":"10.1016\/j.jfma.2017.05.008_bib10","first-page":"145","article-title":"Living donor liver transplantation in Taiwan-challenges beyond surgery","volume":"5","author":"Pillai","year":"2016","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.jfma.2017.05.008_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2005.087262","article-title":"Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study","volume":"56","author":"Merle","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jfma.2017.05.008_bib12","first-page":"959","article-title":"Orthotopic liver transplantation for fulminant and subacute hepatic failure","volume":"34","author":"Stieber","year":"1988","journal-title":"ASAIO Trans"},{"key":"10.1016\/j.jfma.2017.05.008_bib13","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0140-6736(96)08054-3","article-title":"Fulminant hepatic failure","volume":"349","author":"Mas","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jfma.2017.05.008_bib14","first-page":"75","article-title":"Wilson's disease in Taiwan","volume":"17","author":"Chu","year":"2008","journal-title":"Acta Neurol Taiwan"},{"key":"10.1016\/j.jfma.2017.05.008_bib15","first-page":"502","article-title":"Wilson's disease: clinical analysis of 71 cases and comparison with previous Chinese series","volume":"91","author":"Huang","year":"1992","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jfma.2017.05.008_bib16","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S1665-2681(19)31417-6","article-title":"Response to different therapeutic approaches in Wilson disease. A long-term follow up study","volume":"11","author":"Rodriguez","year":"2012","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jfma.2017.05.008_bib17","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/hep.23182","article-title":"Long-term exclusive zinc monotherapy in symptomatic Wilson disease: experience in 17 patients","volume":"50","author":"Linn","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jfma.2017.05.008_bib18","first-page":"448","article-title":"Steroids used to desensitize penicillamine allergy in Wilson disease","volume":"40","author":"Hsu","year":"1999","journal-title":"Acta Paediatr Taiwan"},{"key":"10.1016\/j.jfma.2017.05.008_bib19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S1875-9572(10)60022-8","article-title":"Clinical features and therapeutic response in Taiwanese children with Wilson's disease: 12 years of experience in a single center","volume":"51","author":"Wang","year":"2010","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.jfma.2017.05.008_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1590\/S1807-59322011000300008","article-title":"Wilson's disease in southern Brazil: a 40-year follow-up study","volume":"66","author":"Bem","year":"2011","journal-title":"Clin (Sao Paulo)"},{"key":"10.1016\/j.jfma.2017.05.008_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/MEG.0b013e328358f7da","article-title":"Histologic evolution and long-term outcome of Wilson's disease: results of a single-center experience","volume":"25","author":"Sini","year":"2013","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664617300396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664617300396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T08:51:05Z","timestamp":1569401465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664617300396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0929664617300396"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2017.05.008","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modality of treatment and potential outcome of Wilson disease in Taiwan: A population-based longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2017.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}