{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:37:08Z","timestamp":1761395828154,"version":"build-2065373602"},"reference-count":11,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["109-P13","109-P14"],"award-info":[{"award-number":["109-P13","109-P14"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jfma.2020.08.022","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T16:13:25Z","timestamp":1598372005000},"page":"1269-1273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Experience of the use of hydroxychloroquine on patients with COVID-19: A perspective on viral load and cytokine kinetics"],"prefix":"10.1016","volume":"120","author":[{"given":"Wang-Da","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sui-Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yuan","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui-Hung","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hua","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jui","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Hsien","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jann-Tay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang-Huei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-Chou","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bor-Luen","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Chwen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jfma.2020.08.022_bib1","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1016\/j.jinf.2020.05.018","article-title":"Prescribing COVID-19 treatments: what we should never forget","volume":"81","author":"Tunesi","year":"2020","journal-title":"J Infect"},{"key":"10.1016\/j.jfma.2020.08.022_bib2","doi-asserted-by":"crossref","first-page":"106028","DOI":"10.1016\/j.ijantimicag.2020.106028","article-title":"A review on possible modes of actions of Chloroquine\/Hydroxychloroquine: repurposing against SAR-COV-2 (COVID 19) pandemic [published online ahead of print, 2020 May 22]","author":"Tripathy","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jfma.2020.08.022_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41421-020-0156-0","article-title":"Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in\u00a0vitro","volume":"6","author":"Liu","year":"2020","journal-title":"Cell Discov"},{"key":"10.1016\/j.jfma.2020.08.022_bib4","doi-asserted-by":"crossref","unstructured":"Rosenberg ES, Dufort EM, Udo T, Wilberschied LA, Kumar J, Tesoriero J, et\u00a0al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York state. JAMA. Published online May 11, 2020. doi:10.1001\/jama.2020.8630.","DOI":"10.1001\/jama.2020.8630"},{"key":"10.1016\/j.jfma.2020.08.022_bib5","doi-asserted-by":"crossref","first-page":"m1849","DOI":"10.1136\/bmj.m1849","article-title":"Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial","volume":"369","author":"Tang","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jfma.2020.08.022_bib6","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2016638","article-title":"A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19","author":"Boulware","year":"2020","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jfma.2020.08.022_bib7","first-page":"318","article-title":"Prolonged virus shedding even after seroconversion in a patient with COVID-19","volume":"81","author":"Liu","year":"2020","journal-title":"J Infect"},{"issue":"7809","key":"10.1016\/j.jfma.2020.08.022_bib8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","article-title":"Virological assessment of hospitalized patients with COVID-2019","volume":"581","author":"W\u00f6lfel","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2020.08.022_bib9","doi-asserted-by":"crossref","first-page":"104791","DOI":"10.1016\/j.phrs.2020.104791","article-title":"Could IL-17 represent a new therapeutic target for the treatment and\/or management of COVID-19-related respiratory syndrome?","volume":"156","author":"Casillo","year":"2020","journal-title":"Pharmacol Res"},{"issue":"6","key":"10.1016\/j.jfma.2020.08.022_bib10","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3899\/jrheum.170737","article-title":"Hydroxychloroquine inhibits the differentiation of Th17 cells in systemic lupus erythematosus","volume":"45","author":"Yang","year":"2018","journal-title":"J Rheumatol"},{"issue":"5","key":"10.1016\/j.jfma.2020.08.022_bib11","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462030396X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462030396X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:44:44Z","timestamp":1760539484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092966462030396X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S092966462030396X"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2020.08.022","relation":{},"ISSN":["0929-6646"],"issn-type":[{"type":"print","value":"0929-6646"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experience of the use of hydroxychloroquine on patients with COVID-19: A perspective on viral load and cytokine kinetics","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2020.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}