{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:16:36Z","timestamp":1778559396755,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T00:00:00Z","timestamp":1628380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2314-B-182-033 -"],"award-info":[{"award-number":["109-2314-B-182-033 -"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2314-B-182-036 -MY2"],"award-info":[{"award-number":["110-2314-B-182-036 -MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2314-B-182-017 -"],"award-info":[{"award-number":["MOST 108-2314-B-182-017 -"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012283","name":"Chiayi Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG6G0191"],"award-info":[{"award-number":["CORPG6G0191"]}],"id":[{"id":"10.13039\/501100012283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012283","name":"Chiayi Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG6G0192"],"award-info":[{"award-number":["CORPG6G0192"]}],"id":[{"id":"10.13039\/501100012283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012283","name":"Chiayi Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG6H0441"],"award-info":[{"award-number":["CMRPG6H0441"]}],"id":[{"id":"10.13039\/501100012283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012283","name":"Chiayi Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG6G0193"],"award-info":[{"award-number":["CORPG6G0193"]}],"id":[{"id":"10.13039\/501100012283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jfma.2021.08.006","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T08:25:41Z","timestamp":1629447941000},"page":"1053-1061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["P2Y12 receptor inhibitor plus aspirin versus aspirin treated within 24\u00a0hours of acute noncardioembolic ischemic stroke or TIA: Meta-analysis"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-9234","authenticated-orcid":false,"given":"Wen-Yi","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Ovbiagele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7491-0571","authenticated-orcid":false,"given":"Meng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2021.08.006_bib1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1136\/bmj.37991.635266.44","article-title":"Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services","volume":"328","author":"Coull","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jfma.2021.08.006_bib2","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1161\/STROKEAHA.107.513234","article-title":"Recurrent events in transient ischemic attack and minor stroke: what events are happening and to which patients?","volume":"39","author":"Coutts","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib3","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1161\/01.STR.20.11.1494","article-title":"A comparison of risk factors and prognosis for transient ischemic attacks and minor ischemic strokes. The Oxfordshire Community Stroke Project","volume":"20","author":"Dennis","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib4","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S1474-4422(07)70274-0","article-title":"Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis","volume":"6","author":"Giles","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jfma.2021.08.006_bib5","doi-asserted-by":"crossref","first-page":"k5108","DOI":"10.1136\/bmj.k5108","article-title":"Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis","volume":"363","author":"Hao","year":"2018","journal-title":"BMJ"},{"issue":"22","key":"10.1016\/j.jfma.2021.08.006_bib6","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1001\/jama.284.22.2901","article-title":"Short-term prognosis after emergency department diagnosis of TIA","volume":"284","author":"Johnston","year":"2000","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jfma.2021.08.006_bib7","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1001\/archinte.167.22.2417","article-title":"Early risk of stroke after transient ischemic attack: a systematic review and meta-analysis","volume":"167","author":"Wu","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jfma.2021.08.006_bib8","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Kernan","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib9","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STROKEAHA.118.022606","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1056\/NEJMoa1800410","article-title":"Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA","volume":"379","author":"Johnston","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2021.08.006_bib11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S1474-4422(07)70250-8","article-title":"Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial","volume":"6","author":"Kennedy","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jfma.2021.08.006_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1215340","article-title":"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack","volume":"369","author":"Wang","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2021.08.006_bib13","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1161\/STROKEAHA.115.012293","article-title":"Recurrent ischemic lesions after acute atherothrombotic stroke: clopidogrel plus aspirin versus aspirin alone","volume":"47","author":"Hong","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1056\/NEJMoa1916870","article-title":"Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA","volume":"383","author":"Johnston","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2021.08.006_bib15","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.jfma.2021.08.006_bib16","series-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins","year":"2011"},{"key":"10.1016\/j.jfma.2021.08.006_bib17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.jfma.2021.08.006_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jfma.2021.08.006_bib19","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/STROKEAHA.118.024497","article-title":"Antiplatelet therapy after noncardioembolic stroke","volume":"50","author":"Greving","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib20","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1001\/jamaneurol.2019.2531","volume":"76","author":"Pan","year":"2019","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jfma.2021.08.006_bib21","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1161\/STROKEAHA.118.020553","article-title":"Efficacy and safety of ticagrelor in relation to aspirin use within the week before randomization in the SOCRATES trial","volume":"49","author":"Wong","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejim.2021.05.022","article-title":"Risk of stroke in CYP2C19 LoF polymorphism carrier coronary artery disease patients undergoing clopidogrel therapy: an ethnicity-based updated meta-analysis","volume":"90","author":"Jafrin","year":"2021","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jfma.2021.08.006_bib23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/svn-2020-000791","article-title":"Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial","volume":"6","author":"Wang","year":"2021","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.jfma.2021.08.006_bib24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1212\/WNL.0000000000001844","article-title":"Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy","volume":"85","author":"Wang","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.jfma.2021.08.006_bib25","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/STROKEAHA.119.027465","article-title":"Disability after minor stroke and transient ischemic attack in the POINT trial","volume":"51","author":"Cucchiara","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2018.8496","article-title":"Effect of alteplase vs aspirin on functional outcome for patients with acute ischemic stroke and minor nondisabling neurologic deficits: the PRISMS randomized clinical trial","volume":"320","author":"Khatri","year":"2018","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jfma.2021.08.006_bib27","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1161\/STROKEAHA.120.033040","article-title":"P2Y12 inhibitors plus aspirin versus aspirin alone in patients with minor stroke or high-risk transient ischemic attack","volume":"52","author":"Li","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib28","doi-asserted-by":"crossref","first-page":"e468","DOI":"10.1161\/STR.0000000000000377","article-title":"Benefits and risks of dual versus single antiplatelet therapy for secondary stroke prevention: a systematic review for the 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack","volume":"52","author":"Brown","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.jfma.2021.08.006_bib29","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1161\/STROKEAHA.120.033033","article-title":"Dual antiplatelet therapy versus aspirin in patients with stroke or transient ischemic attack: meta-analysis of randomized controlled trials","volume":"52","author":"Bhatia","year":"2021","journal-title":"Stroke"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664621003648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664621003648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:05:49Z","timestamp":1778558749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664621003648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0929664621003648"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2021.08.006","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P2Y12 receptor inhibitor plus aspirin versus aspirin treated within 24\u00a0hours of acute noncardioembolic ischemic stroke or TIA: Meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2021.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}