{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:39:24Z","timestamp":1787974764430,"version":"build-2784847793"},"reference-count":17,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["109-TFDA-D-110"],"award-info":[{"award-number":["109-TFDA-D-110"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009210","name":"Food and Drug Administration","doi-asserted-by":"publisher","award":["MOHW 109-TFDA-D-110"],"award-info":[{"award-number":["MOHW 109-TFDA-D-110"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jfma.2021.09.025","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T01:09:50Z","timestamp":1634692190000},"page":"1397-1405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Analysis of severe cutaneous adverse reactions (SCARs) in Taiwan drug-injury relief system: 18-year results"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1360-7149","authenticated-orcid":false,"given":"Po-Wei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Han","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4980-5665","authenticated-orcid":false,"given":"Mei-Yi","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2021.09.025_bib1","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1056\/NEJMcp1104080","article-title":"Exanthematous drug eruptions","volume":"366","author":"Stern","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2021.09.025_bib2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/1346-8138.13430","article-title":"Severe cutaneous adverse drug reactions","volume":"43","author":"Chung","year":"2016","journal-title":"J Dermatol"},{"key":"10.1016\/j.jfma.2021.09.025_bib3","first-page":"1503709","article-title":"Treatments for severe cutaneous adverse reactions","author":"Cho","year":"2017","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jfma.2021.09.025_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2340\/00015555-2295","article-title":"Long-term sequelae of Stevens-Johnson syndrome\/toxic epidermal necrolysis","volume":"96","author":"Yang","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jfma.2021.09.025_bib5","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1001\/archdermatol.2010.198","article-title":"Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases","volume":"146","author":"Chen","year":"2010","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jfma.2021.09.025_bib6","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/bjd.12133","article-title":"Prognosis of generalized bullous fixed drug eruption: comparison with Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"168","author":"Lipowicz","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jfma.2021.09.025_bib7","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/S0140-6736(16)30378-6","article-title":"Severe cutaneous adverse reactions to drugs","volume":"390","author":"Duong","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jfma.2021.09.025_bib8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","article-title":"The DRESS syndrome: a literature review","volume":"124","author":"Cacoub","year":"2011","journal-title":"Am J Med"},{"key":"10.1016\/j.jfma.2021.09.025_bib9","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/cpt.1474","article-title":"A realistic review of the drug-injury relief system in Taiwan: challenges, lessons, and achievements","volume":"106","author":"Chen","year":"2019","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jfma.2021.09.025_bib10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1365-2125.2010.03774.x","article-title":"Epidemiology and risk factors for drug allergy","volume":"71","author":"Thong","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jfma.2021.09.025_bib11","first-page":"73","article-title":"A 10-years retrospective study on severe cutaneous adverse reactions (SCARs) in a tertiary hospital in penang, Malaysia","volume":"73","author":"Loo","year":"2018","journal-title":"Med J Malaysia"},{"key":"10.1016\/j.jfma.2021.09.025_bib12","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/bjd.15423","article-title":"Recent advances in the understanding of severe cutaneous adverse reactions","volume":"177","author":"Adler","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jfma.2021.09.025_bib13","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/bjd.12501","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study","volume":"169","author":"Kardaun","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jfma.2021.09.025_bib14","first-page":"410","article-title":"Israeli RegiSCAR Network. profile of acute generalized exanthematous pustulosis in Israel during 2002-2005: results of the RegiSCAR Study","volume":"10","author":"Davidovici","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.jfma.2021.09.025_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jaad.2013.11.015","article-title":"Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome\/toxic epidermal necrolysis by immunohistopathological features","volume":"70","author":"Cho","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jfma.2021.09.025_bib16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens-Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2021.09.025_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.fpc.0000199500.46842.4a","article-title":"Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions","volume":"16","author":"Hung","year":"2006","journal-title":"Pharmacogenetics Genom"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462100471X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462100471X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:48:51Z","timestamp":1760539731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092966462100471X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S092966462100471X"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2021.09.025","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of severe cutaneous adverse reactions (SCARs) in Taiwan drug-injury relief system: 18-year results","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2021.09.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}