{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:45:33Z","timestamp":1786992333377,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["106-TDUB-211-113002"],"award-info":[{"award-number":["106-TDUB-211-113002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["107-TDU-B-211-123002"],"award-info":[{"award-number":["107-TDU-B-211-123002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["102-2314-B-002-158-MY3"],"award-info":[{"award-number":["102-2314-B-002-158-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["104-2314-B002-241"],"award-info":[{"award-number":["104-2314-B002-241"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2314-B-002-181"],"award-info":[{"award-number":["107-2314-B-002-181"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2321-B-002 -045"],"award-info":[{"award-number":["109-2321-B-002 -045"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2634-F-002-029"],"award-info":[{"award-number":["MOST 109-2634-F-002-029"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST109-2314-B-002 -238"],"award-info":[{"award-number":["MOST109-2314-B-002 -238"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jfma.2021.11.009","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T07:46:18Z","timestamp":1638603978000},"page":"1668-1679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparisons of the clinical and mycological characteristics of pediatric candidemia"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-1221","authenticated-orcid":false,"given":"Wan-Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-9644","authenticated-orcid":false,"given":"Ting-Yu","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Ing","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-1956","authenticated-orcid":false,"given":"Luan-Ying","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jfma.2021.11.009_bib1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/myc.12792","article-title":"Candidemia in children: epidemiology, prevention and management","volume":"61","author":"Mantadakis","year":"2018","journal-title":"Mycoses"},{"issue":"10","key":"10.1016\/j.jfma.2021.11.009_bib2","article-title":"Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants","author":"Cleminson","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.jfma.2021.11.009_bib3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJMoa061094","article-title":"Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia","volume":"356","author":"Cornely","year":"2007","journal-title":"N Engl J Med"},{"issue":"12b","key":"10.1016\/j.jfma.2021.11.009_bib4","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1111\/imj.12595","article-title":"Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014","volume":"44","author":"Fleming","year":"2014","journal-title":"Intern Med J"},{"issue":"3","key":"10.1016\/j.jfma.2021.11.009_bib5","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1093\/jpids\/piy009","article-title":"Neonatal and pediatric candidemia: results from population-based active laboratory surveillance in four US locations, 2009-2015","volume":"7","author":"Benedict","year":"2018","journal-title":"J Pediatr Infect Dis Soc"},{"issue":"5","key":"10.1016\/j.jfma.2021.11.009_bib6","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1542\/peds.2008-2055","article-title":"Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients","volume":"123","author":"Blyth","year":"2009","journal-title":"Pediatrics"},{"issue":"suppl_3","key":"10.1016\/j.jfma.2021.11.009_bib7","doi-asserted-by":"crossref","first-page":"S445","DOI":"10.1093\/infdis\/jix131","article-title":"Multidrug-resistant Candida: epidemiology, molecular mechanisms, and treatment","volume":"216","author":"Arendrup","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfma.2021.11.009_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2147\/IDR.S184884","article-title":"Resistance rates of non-albicans Candida infections in Taiwan after the revision of 2012 clinical and laboratory standards institute breakpoints","volume":"12","author":"Hii","year":"2019","journal-title":"Infect Drug Resist"},{"issue":"6","key":"10.1016\/j.jfma.2021.11.009_bib9","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.fgb.2008.03.011","article-title":"Molecular phylogenetic analysis of Candida tropicalis isolates by multi-locus sequence typing","volume":"45","author":"Jacobsen","year":"2008","journal-title":"Fungal Genet Biol"},{"issue":"9","key":"10.1016\/j.jfma.2021.11.009_bib10","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3201\/eid2509.190520","article-title":"Clonality of fluconazole-nonsusceptible Candida tropicalis in bloodstream infections, Taiwan, 2011-2017","volume":"25","author":"Chen","year":"2019","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"10.1016\/j.jfma.2021.11.009_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/archpedi.160.3.293","article-title":"Development of pediatric comorbidity prediction model","volume":"160","author":"Tai","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"10","key":"10.1016\/j.jfma.2021.11.009_bib12","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2017.2352","article-title":"Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the sepsis-3 definitions in critically ill children","volume":"171","author":"Matics","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"2","key":"10.1016\/j.jfma.2021.11.009_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1086\/499057","article-title":"Current treatment strategies for disseminated candidiasis","volume":"42","author":"Spellberg","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.jfma.2021.11.009_bib14","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and update of the consensus definitions of invasive fungal disease from the European organization for research and treatment of cancer and the mycoses study group education and research consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.jfma.2021.11.009_bib15","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1128\/JCM.00937-12","article-title":"Progress in antifungal susceptibility testing of Candida spp. by use of clinical and laboratory standards institute broth microdilution methods, 2010 to 2012","volume":"50","author":"Pfaller","year":"2012","journal-title":"J Clin Microbiol"},{"issue":"11","key":"10.1016\/j.jfma.2021.11.009_bib16","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1128\/JCM.43.11.5593-5600.2005","article-title":"Multilocus sequence typing for differentiation of strains of Candida tropicalis","volume":"43","author":"Tavanti","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.jfma.2021.11.009_bib17","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/s41598-017-01123-6","article-title":"Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia","volume":"7","author":"Tsai","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jfma.2021.11.009_bib18","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1542\/peds.2005-1969","article-title":"Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants","volume":"117","author":"Uko","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.jfma.2021.11.009_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/jp.2011.27","article-title":"Impact of \u2018targeted\u2019 fluconazole prophylaxis for preterm neonates: efficacy of a highly selective approach?","volume":"32","author":"Martin","year":"2012","journal-title":"J Perinatol"},{"issue":"5","key":"10.1016\/j.jfma.2021.11.009_bib20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/INF.0000000000002207","article-title":"Pediatric candidemia epidemiology and morbidities: a nationwide cohort","volume":"38","author":"Lausch","year":"2019","journal-title":"Pediatr Infect Dis J"},{"issue":"2","key":"10.1016\/j.jfma.2021.11.009_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1574-6976.2011.00278.x","article-title":"Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance","volume":"36","author":"Silva","year":"2012","journal-title":"FEMS Microbiol Rev"},{"issue":"2","key":"10.1016\/j.jfma.2021.11.009_bib22","doi-asserted-by":"crossref","first-page":"e00111","DOI":"10.1128\/CMR.00111-18","article-title":"Candida parapsilosis: from genes to the bedside","volume":"32","author":"T\u00f3th","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jfma.2021.11.009_bib23","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.3389\/fmicb.2017.01927","article-title":"An update on Candida tropicalis based on basic and clinical approaches","volume":"8","author":"Zuza-Alves","year":"2017","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.jfma.2021.11.009_bib24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s12879-019-4260-4","article-title":"Chronic disseminated candidiasis manifesting as hepatosplenic abscesses among patients with hematological malignancies","volume":"19","author":"Chen","year":"2019","journal-title":"BMC Infect Dis"},{"issue":"1","key":"10.1016\/j.jfma.2021.11.009_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/myc.13002","article-title":"Clinical features and outcome of hepatosplenic fungal infections in children with haematological malignancies","volume":"63","author":"Madney","year":"2020","journal-title":"Mycoses"},{"issue":"3","key":"10.1016\/j.jfma.2021.11.009_bib26","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jinf.2017.06.005","article-title":"Fruits as the vehicle of drug resistant pathogenic yeasts","volume":"75","author":"Lo","year":"2017","journal-title":"J Infect"},{"key":"10.1016\/j.jfma.2021.11.009_bib27","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.meegid.2016.07.026","article-title":"Multilocus sequence typing of Candida tropicalis shows clonal cluster enrichment in azole-resistant isolates from patients in Shanghai, China","volume":"44","author":"Wang","year":"2016","journal-title":"Infect Genet Evol"},{"issue":"1","key":"10.1016\/j.jfma.2021.11.009_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12879-018-3082-0","article-title":"MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates","volume":"18","author":"Jin","year":"2018","journal-title":"BMC Infect Dis"},{"issue":"1","key":"10.1016\/j.jfma.2021.11.009_bib29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1542\/peds.2004-2292","article-title":"Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months","volume":"117","author":"Benjamin","year":"2006","journal-title":"Pediatrics"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664621005295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664621005295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:48:17Z","timestamp":1760539697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664621005295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0929664621005295"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2021.11.009","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparisons of the clinical and mycological characteristics of pediatric candidemia","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2021.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}