{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:51:02Z","timestamp":1760575862513,"version":"build-2065373602"},"reference-count":22,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","award":["20180550912","81401485"],"award-info":[{"award-number":["20180550912","81401485"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jfma.2022.05.011","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T16:52:28Z","timestamp":1654534348000},"page":"2501-2511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Response surface model comparison and combinations for remifentanil and propofol in describing response to esophageal instrumentation and adverse respiratory events"],"prefix":"10.1016","volume":"121","author":[{"given":"Ziyi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Kun","family":"Ting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara M.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jfma.2022.05.011_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00000542-200302000-00008","article-title":"Response surface modeling of remifentanil\u2013propofol interaction on cardiorespiratory control and bispectral index","volume":"98","author":"Nieuwenhuijs","year":"2003","journal-title":"J Anesthesiol"},{"issue":"6","key":"10.1016\/j.jfma.2022.05.011_bib2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/bja\/aeq081","article-title":"Analysis of pharmacodynamic interaction of sevoflurane and propofol on bispectral index during general anaesthesia using a response surface model","volume":"104","author":"Diz","year":"2010","journal-title":"J British Journal of Anaesthesia"},{"issue":"4","key":"10.1016\/j.jfma.2022.05.011_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/ALN.0b013e3181b799ef","article-title":"Response surface modeling of the interaction between propofol and sevoflurane","volume":"111","author":"Schumacher","year":"2009","journal-title":"J Anesthesiol"},{"issue":"3","key":"10.1016\/j.jfma.2022.05.011_bib4","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1213\/ANE.0b013e318210fc45","article-title":"An exploration of remifentanil-propofol combinations that lead to a loss of response to esophageal instrumentation, a loss of responsiveness, and\/or onset of intolerable ventilatory depression","volume":"113","author":"LaPierre","year":"2011","journal-title":"J Anesthe Analgesia"},{"key":"10.1016\/j.jfma.2022.05.011_bib5","series-title":"Total intravenous anesthesia and target controlled infusions","first-page":"117","article-title":"Pharmacokinetic\u2013Pharmacodynamic modelling of anesthetic drugs","author":"Proost","year":"2017"},{"issue":"4","key":"10.1016\/j.jfma.2022.05.011_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.aat.2015.06.005","article-title":"Response surface models in the field of anesthesia: a crash course","volume":"53","author":"Liou","year":"2015","journal-title":"J Acta Anaesthesiologica Taiwanica"},{"issue":"3","key":"10.1016\/j.jfma.2022.05.011_bib7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3565(24)29450-7","article-title":"Drug synergism: its detection and applications","volume":"298","author":"Tallarida","year":"2001","journal-title":"J J Pharma Experi Therapeutics"},{"key":"10.1016\/j.jfma.2022.05.011_bib8","series-title":"Biopharmaceutics and pharmacokinetics","first-page":"238","author":"SL W, Q Z","year":"2004"},{"issue":"2","key":"10.1016\/j.jfma.2022.05.011_bib9","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/ALN.0b013e31825fb1b2","article-title":"A simulation study of common propofol and propofol-opioid dosing regimens for upper EndoscopyImplications on the time course of recovery","volume":"117","author":"LaPierre","year":"2012","journal-title":"J Anesthesiol"},{"issue":"6","key":"10.1016\/j.jfma.2022.05.011_bib10","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1097\/00000542-200006000-00017","article-title":"Response surface model for anesthetic drug interactions","volume":"92","author":"Minto","year":"2000","journal-title":"J Anesthesiol"},{"issue":"6","key":"10.1016\/j.jfma.2022.05.011_bib11","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1097\/00000542-200406000-00006","article-title":"Pharmacodynamic interaction between propofol and remifentanil regarding hypnosis, tolerance of laryngoscopy, bispectral index, and electroencephalographic approximate entropy","volume":"100","author":"Bouillon","year":"2004","journal-title":"J Anesthesiol"},{"issue":"2","key":"10.1016\/j.jfma.2022.05.011_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1213\/ANE.0000000000001299","article-title":"Predicting the best fit: a comparison of response surface models for midazolam and alfentanil sedation in procedures with varying stimulation","volume":"123","author":"Liou","year":"2016","journal-title":"J Anesthesia & Analgesia"},{"issue":"2","key":"10.1016\/j.jfma.2022.05.011_bib13","first-page":"311","article-title":"Sevoflurane remifentanil interaction: comparison of different response surface models","volume":"116","author":"Heyse","year":"2012","journal-title":"J The Journal of the American Society of Anesthesiologists"},{"issue":"17","key":"10.1016\/j.jfma.2022.05.011_bib14","first-page":"5318","article-title":"Application of a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-\u03b2-d-Arabinofuranosylcytosine","volume":"50","author":"Greco","year":"1990","journal-title":"J Cancer Res"},{"key":"10.1016\/j.jfma.2022.05.011_bib15","series-title":"Modern anesthetics","first-page":"471","article-title":"Hypnotic and opioid anesthetic drug interactions on the CNS, focus on response surface modeling","author":"Bouillon","year":"2008"},{"issue":"4","key":"10.1016\/j.jfma.2022.05.011_bib16","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/ALN.0b013e3181d40368","article-title":"Noxious stimulation response IndexA novel anesthetic state index based on hypnotic\u2013opioid interaction","volume":"112","author":"Luginb\u00fchl","year":"2010","journal-title":"J Anesthesiol"},{"issue":"5","key":"10.1016\/j.jfma.2022.05.011_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF02353864","article-title":"Comparison of the Akaike Information Criterion, the Schwarz criterion and the F test as guides to model selection","volume":"22","author":"Ludden","year":"1994","journal-title":"J J Pharma Biopharm"},{"issue":"6","key":"10.1016\/j.jfma.2022.05.011_bib18","first-page":"1373","article-title":"A response surface analysis of propofol\u2013remifentanil pharmacodynamic interaction in volunteers","volume":"100","author":"Kern","year":"2004","journal-title":"J The J Am Soc Anesthe"},{"issue":"1","key":"10.1016\/j.jfma.2022.05.011_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0022-3565(24)39076-7","article-title":"Quantification of pharmacodynamic interactions between dexmedetomidine and midazolam in the rat","volume":"294","author":"Bol","year":"2000","journal-title":"J J Pharm Exper Therapeutics"},{"issue":"1","key":"10.1016\/j.jfma.2022.05.011_bib20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.pharmtox.47.120505.105154","article-title":"Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis","volume":"47","author":"Danhof","year":"2007","journal-title":"J Annual Rev Pharm Toxi"},{"issue":"5","key":"10.1016\/j.jfma.2022.05.011_bib21","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bja.2018.01.018","article-title":"Pharmacokinetic\u2013pharmacodynamic model for propofol for broad application in anaesthesia and sedation","volume":"120","author":"Eleveld","year":"2018","journal-title":"J British J Anaesthe"},{"issue":"2","key":"10.1016\/j.jfma.2022.05.011_bib22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bja.2020.10.027","article-title":"Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia","volume":"126","author":"Vellinga","year":"2021","journal-title":"J Bri J Anaesthe"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664622002169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664622002169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:49:40Z","timestamp":1760539780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664622002169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0929664622002169"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2022.05.011","relation":{},"ISSN":["0929-6646"],"issn-type":[{"type":"print","value":"0929-6646"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Response surface model comparison and combinations for remifentanil and propofol in describing response to esophageal instrumentation and adverse respiratory events","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2022.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}