{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:43:00Z","timestamp":1790923380949,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-075-005"],"award-info":[{"award-number":["NSTC 112-2314-B-075-005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V112C-181"],"award-info":[{"award-number":["V112C-181"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jfma.2024.10.025","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T04:35:20Z","timestamp":1730522120000},"page":"413-418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics and outcomes of ICU-admitted COVID-19 patients in the Omicron and Alpha-dominated periods"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-9651","authenticated-orcid":false,"given":"Chih-Jung","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhong-Ru","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Chin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Yen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ting","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Jui","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4172-5529","authenticated-orcid":false,"given":"Wei-Chih","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yih","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Yao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jfma.2024.10.025_bib1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00134-020-06092-5","article-title":"Managing ICU surge during the COVID-19 crisis: rapid guidelines","volume":"46","author":"Aziz","year":"2020","journal-title":"Intensive Care Med"},{"issue":"8","key":"10.1016\/j.jfma.2024.10.025_bib2","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1097\/CCM.0000000000004410","article-title":"Adult ICU triage during the coronavirus disease 2019 pandemic: who will live and who will die? Recommendations to improve survival","volume":"48","author":"Sprung","year":"2020","journal-title":"Crit Care Med"},{"issue":"16","key":"10.1016\/j.jfma.2024.10.025_bib3","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/jama.2020.5394","article-title":"Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the lombardy region, Italy","volume":"323","author":"Grasselli","year":"2020","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.jfma.2024.10.025_bib4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/anae.15425","article-title":"Mortality in patients admitted to intensive care with COVID-19: an updated systematic review and meta-analysis of observational studies","volume":"76","author":"Armstrong","year":"2021","journal-title":"Anaesthesia"},{"issue":"22","key":"10.1016\/j.jfma.2024.10.025_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11226796","article-title":"Clinical outcomes and prolonged SARS-CoV-2 viral shedding in ICU patients with severe COVID-19 infection and nosocomial bacterial pneumonia: a retrospective cohort study","volume":"11","author":"Sun","year":"2022","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.jfma.2024.10.025_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/life12020170","article-title":"SARS-CoV-2 variants and clinical outcomes: a systematic review","volume":"12","author":"Mendiola-Pastrana","year":"2022","journal-title":"Life"},{"issue":"3","key":"10.1016\/j.jfma.2024.10.025_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/v15030618","article-title":"Surfing the waves: differences in hospitalised COVID-19 patients across 4 variant waves in a Belgian university hospital","volume":"15","author":"Seyler","year":"2023","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.jfma.2024.10.025_bib8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S2213-2600(20)30161-2","article-title":"Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations","volume":"8","author":"Phua","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.jfma.2024.10.025_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13054-020-02916-4","article-title":"Preparing your intensive care unit for the COVID-19 pandemic: practical considerations and strategies","volume":"24","author":"Goh","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.jfma.2024.10.025_bib10","first-page":"2022","article-title":"Clinical outcomes among patients infected with Omicron (B.1.1.529) SARS-CoV-2 variant in southern California","author":"Lewnard","year":"2022","journal-title":"medRxiv"},{"issue":"1","key":"10.1016\/j.jfma.2024.10.025_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12998\/wjcc.v10.i1.1","article-title":"Omicron variant (B.1.1.529) of SARS-CoV-2: mutation, infectivity, transmission, and vaccine resistance","volume":"10","author":"Ren","year":"2022","journal-title":"World J Clin Cases"},{"issue":"1","key":"10.1016\/j.jfma.2024.10.025_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41392-022-01009-8","article-title":"Omicron: increased transmissibility and decreased pathogenicity","volume":"7","author":"B\u00e1lint","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"issue":"50","key":"10.1016\/j.jfma.2024.10.025_bib14","first-page":"1731","article-title":"SARS-CoV-2 B.1.1.529 (omicron) variant - United States","volume":"70","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7902","key":"10.1016\/j.jfma.2024.10.025_bib15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-022-04442-5","article-title":"Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron","volume":"603","author":"Shuai","year":"2022","journal-title":"Nature"},{"issue":"10335","key":"10.1016\/j.jfma.2024.10.025_bib16","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(22)00327-0","article-title":"Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study","volume":"399","author":"Menni","year":"2022","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.jfma.2024.10.025_bib17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1001\/jama.2021.24868","article-title":"Characteristics and outcomes of hospitalized patients in South Africa during the COVID-19 omicron wave compared with previous waves","volume":"327","author":"Maslo","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jfma.2024.10.025_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101455","article-title":"Severe hospital events following symptomatic infection with Sars-CoV-2 Omicron and Delta variants in France, December 2021-January 2022: a retrospective, population-based, matched cohort study","volume":"48","author":"Auvigne","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"11","key":"10.1016\/j.jfma.2024.10.025_bib19","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/jcmm.17747","article-title":"Severity of the Omicron SARS-CoV-2 variant compared with the previous lineages: a systematic review","volume":"27","author":"Arabi","year":"2023","journal-title":"J Cell Mol Med"},{"issue":"6","key":"10.1016\/j.jfma.2024.10.025_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.15585\/mmwr.mm7106e2","volume":"71","author":"Modes","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"3","key":"10.1016\/j.jfma.2024.10.025_bib21","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1093\/cid\/ciac571","article-title":"Clinical characteristics and outcomes of immunocompromised patients with coronavirus disease 2019 caused by the omicron variant: a prospective, observational study","volume":"76","author":"Malahe","year":"2023","journal-title":"Clin Infect Dis"},{"issue":"7858","key":"10.1016\/j.jfma.2024.10.025_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-021-03426-1","article-title":"Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7","volume":"593","author":"Davies","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2024.10.025_bib23","article-title":"Identification and analysis of SARS-CoV-2 Alpha variants in the largest taiwan COVID-19 outbreak in 2021","volume":"9","author":"Liu","year":"2022","journal-title":"Front Med"},{"issue":"4","key":"10.1016\/j.jfma.2024.10.025_bib24","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3201\/eid2904.221497","article-title":"Emergence and persistent dominance of SARS-CoV-2 omicron BA.2.3.7 variant, taiwan","volume":"29","author":"Shao","year":"2023","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"10.1016\/j.jfma.2024.10.025_bib25","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1038\/s41467-022-33801-z","article-title":"Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19","volume":"13","author":"de Prost","year":"2022","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jfma.2024.10.025_bib26","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3390\/idr14030052","article-title":"COVID-19 variants in critically ill patients: a comparison of the delta and omicron variant profiles","volume":"14","author":"Corriero","year":"2022","journal-title":"Infect Dis Rep"},{"key":"10.1016\/j.jfma.2024.10.025_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.resmer.2023.100990","article-title":"Impact of SARS-CoV-2 Omicron and Delta variants in patients requiring intensive care unit (ICU) admission for COVID-19, Northern Italy, December 2021 to January 2022","volume":"83","author":"Piralla","year":"2023","journal-title":"Respiratory Medicine and Research"},{"issue":"6","key":"10.1016\/j.jfma.2024.10.025_bib28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00134-023-07039-2","article-title":"Variants of concern and clinical outcomes in critically ill COVID-19 patients","volume":"49","year":"2023","journal-title":"Intensive Care Med"},{"issue":"Suppl 1","key":"10.1016\/j.jfma.2024.10.025_bib29","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.jfma.2023.07.003","article-title":"Critical care response during the COVID-19 pandemic","volume":"123","author":"Chen","year":"2024","journal-title":"J Formos Med Assoc"},{"issue":"6","key":"10.1016\/j.jfma.2024.10.025_bib30","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00134-021-06416-z","article-title":"Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials","volume":"47","author":"Snow","year":"2021","journal-title":"Intensive Care Med"},{"issue":"12","key":"10.1016\/j.jfma.2024.10.025_bib31","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.jfma.2022.07.006","article-title":"COVID-19-associated pulmonary aspergillosis is associated with increased in-hospital mortality and prolonged SARS-CoV-2 viral shedding","volume":"121","author":"Huang","year":"2022","journal-title":"J Formos Med Assoc"},{"issue":"3","key":"10.1016\/j.jfma.2024.10.025_bib32","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1097\/CCM.0000000000004899","article-title":"Surviving sepsis campaign guidelines on the management of adults with coronavirus disease 2019 (COVID-19) in the ICU: first update","volume":"49","author":"Alhazzani","year":"2021","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.jfma.2024.10.025_bib33","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1038\/s41598-023-34613-x","article-title":"An observational study on factors associated with ICU mortality in Covid-19 patients and critical review of the literature","volume":"13","author":"Lavrentieva","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jfma.2024.10.025_bib34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/MAT.0000000000001837","article-title":"Rising mortality in coronavirus-19 patients supported with extracorporeal membrane oxygenation","volume":"69","author":"Rando","year":"2023","journal-title":"Asaio j"},{"issue":"1","key":"10.1016\/j.jfma.2024.10.025_bib35","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1093\/cid\/ciab875","article-title":"Remdesivir treatment in hospitalized patients with coronavirus disease 2019 (COVID-19): a comparative analysis of in-hospital all-cause mortality in a large multicenter observational cohort","volume":"75","author":"Mozaffari","year":"2022","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.jfma.2024.10.025_bib36","article-title":"Effect of tocilizumab on mortality in patients with SARS-CoV-2 pneumonia caused by delta or omicron variants: a propensity-matched analysis in nimes university hospital, France","volume":"12","author":"Laffont-Lozes","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jfma.2024.10.025_bib37","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.13.06017","article-title":"Changes in all-cause and cause-specific excess mortality before and after the Omicron outbreak of COVID-19 in Hong Kong","volume":"13","author":"Chong","year":"2023","journal-title":"J Glob Health"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664624005126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664624005126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T01:47:22Z","timestamp":1747964842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664624005126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0929664624005126"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2024.10.025","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics and outcomes of ICU-admitted COVID-19 patients in the Omicron and Alpha-dominated periods","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2024.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}