{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:59:20Z","timestamp":1778403560172,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jfma.2024.11.009","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:28:16Z","timestamp":1732778896000},"page":"1171-1176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of radiation dose on chemoradiation outcomes and rectum preservation in locally advanced rectal cancer: A retrospective study"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-1195","authenticated-orcid":false,"given":"Pei-Hsuan","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hsin","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-1758","authenticated-orcid":false,"given":"Been-Ren","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hsuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2024.11.009_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial","volume":"12","author":"van Gijn","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib2","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1200\/JCO.2011.40.1836","article-title":"Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO\/ARO\/AIO-94 randomized phase III trial after a median follow-up of 11 years","volume":"30","author":"Sauer","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib3","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1200\/JCO.2009.22.0467","article-title":"Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03","volume":"27","author":"Roh","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib4","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1200\/JCO.2016.66.6198","article-title":"Modified FOLFOX6 with or without radiation versus fluorouracil and leucovorin with radiation in neoadjuvant treatment of locally advanced rectal cancer: initial results of the Chinese FOWARC multicenter, open-label, randomized three-arm phase III trial","volume":"34","author":"Deng","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.clon.2020.06.008","article-title":"Neoadjuvant radiotherapy dose escalation in locally advanced rectal cancer: a systematic review and meta-analysis of modern treatment approaches and outcomes","volume":"33","author":"Hearn","year":"2021","journal-title":"Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib6","first-page":"388","article-title":"Morbidity and mortality following abdominoperineal resection for low rectal adenocarcinoma","volume":"53","author":"Luna-Perez","year":"2001","journal-title":"Rev Invest Clin"},{"key":"10.1016\/j.jfma.2024.11.009_bib7","first-page":"106","article-title":"Bowel function 14 years after preoperative short-course radiotherapy and total mesorectal excision for rectal cancer: report of a multicenter randomized trial","volume":"14","author":"Chen","year":"2015","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.jfma.2024.11.009_bib8","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.sla.0000141194.27992.32","article-title":"Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results","volume":"240","author":"Habr-Gama","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.jfma.2024.11.009_bib9","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.gassur.2006.09.005","article-title":"Patterns of failure and survival for nonoperative treatment of stage c0 distal rectal cancer following neoadjuvant chemoradiation therapy","volume":"10","author":"Habr-Gama","year":"2006","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.jfma.2024.11.009_bib10","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ijrobp.2013.12.012","article-title":"Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control","volume":"88","author":"Habr-Gama","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jfma.2024.11.009_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijrobp.2012.05.017","article-title":"Radiation dose-response model for locally advanced rectal cancer after preoperative chemoradiation therapy","volume":"85","author":"Appelt","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jfma.2024.11.009_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12094-016-1522-0","article-title":"Radiation dose intensification in pre-operative chemo-radiotherapy for locally advanced rectal cancer","volume":"19","author":"Alongi","year":"2017","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/COC.0b013e318161dbd3","article-title":"Preoperative capecitabine and accelerated intensity-modulated radiotherapy in locally advanced rectal cancer: a phase II trial","volume":"31","author":"Ballonoff","year":"2008","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijrobp.2015.05.005","article-title":"NRG Oncology radiation therapy Oncology group 0822: a phase 2 study of preoperative chemoradiation therapy using intensity modulated radiation therapy in combination with capecitabine and oxaliplatin for patients with locally advanced rectal cancer","volume":"93","author":"Hong","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jfma.2024.11.009_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1470-2045(20)30557-X","article-title":"Conditional recurrence-free survival of clinical complete responders managed by watch and wait after neoadjuvant chemoradiotherapy for rectal cancer in the International Watch & Wait Database: a retrospective, international, multicentre registry study","volume":"22","author":"Fernandez","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib16","article-title":"Effect of increasing radiation dose for rectal cancer patients with nonoperative management after neoadjuvant chemoradiotherapy","volume":"36","author":"Jinghua Tang","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib17","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1200\/JCO.2011.37.7176","article-title":"Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer","volume":"29","author":"Maas","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw171","article-title":"Long-term outcome of an organ preservation program after neoadjuvant treatment for rectal cancer","volume":"108","author":"Martens","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jfma.2024.11.009_bib19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(15)00467-2","article-title":"Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis","volume":"17","author":"Renehan","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib20","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.5896","article-title":"Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy","volume":"5","author":"Smith","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/DCR.0b013e3182a25c4e","article-title":"Watch and wait approach following extended neoadjuvant chemoradiation for distal rectal cancer: are we getting closer to anal cancer management?","volume":"56","author":"Habr-Gama","year":"2013","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.jfma.2024.11.009_bib22","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/S0140-6736(18)31078-X","article-title":"Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study","volume":"391","author":"van der Valk","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jfma.2024.11.009_bib23","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S1470-2045(15)00120-5","article-title":"High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study","volume":"16","author":"Appelt","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib24","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1200\/JCO.2012.42.9597","article-title":"Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: trans-Tasman Radiation Oncology Group trial 01.04","volume":"30","author":"Ngan","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jfma.2024.11.009_bib25","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664624005461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664624005461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:52:19Z","timestamp":1763812339000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664624005461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0929664624005461"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2024.11.009","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of radiation dose on chemoradiation outcomes and rectum preservation in locally advanced rectal cancer: A retrospective study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2024.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Formosan Medical Association. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}