{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:00:07Z","timestamp":1791669607459,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011892","name":"Kaohsiung Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8N0151"],"award-info":[{"award-number":["CMRPG8N0151"]}],"id":[{"id":"10.13039\/501100011892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jfma.2025.04.017","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T16:31:16Z","timestamp":1744821076000},"page":"427-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Controlling nutritional status score as a survival prognosticator in patients with head and neck cancer"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-1579","authenticated-orcid":false,"given":"Ming-Hsien","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-0890","authenticated-orcid":false,"given":"Yao-Te","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yuan","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ching","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-7160","authenticated-orcid":false,"given":"Hui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-1060","authenticated-orcid":false,"given":"Wen-Ling","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yen","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0165-771X","authenticated-orcid":false,"given":"Fu-Min","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2025.04.017_bib1","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1038\/s41598-022-09736-2","article-title":"Forecast of peak attainment and imminent decline after 2017 of oral cancer incidence in men in Taiwan","volume":"12","author":"Jhuang","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jfma.2025.04.017_bib2","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jfma.2025.04.017_bib3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jfma.2025.04.017_bib4","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1158\/0008-5472.CAN-08-3845","article-title":"Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas","volume":"69","author":"Ray-Coquard","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jfma.2025.04.017_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12935-020-1094-5","article-title":"Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis","volume":"20","author":"Zhao","year":"2020","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.jfma.2025.04.017_bib6","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/01635581.2017.1367947","article-title":"Clinical value of nutritional status in cancer: what is its impact and how it affects disease progression and prognosis?","volume":"69","author":"Mantzorou","year":"2017","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jfma.2025.04.017_bib7","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/hed.25075","article-title":"Neutrophil-to-lymphocyte ratio in head and neck cancer prognosis: a systematic review and meta-analysis","volume":"40","author":"Mascarella","year":"2018","journal-title":"Head Neck"},{"key":"10.1016\/j.jfma.2025.04.017_bib8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1159\/000502750","article-title":"Platelet-lymphocyte ratio as a predictor of prognosis in head and neck cancer: a systematic review and meta-analysis","volume":"42","author":"Bardash","year":"2019","journal-title":"Oncol Res Treat"},{"key":"10.1016\/j.jfma.2025.04.017_bib9","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.2147\/CMAR.S275635","article-title":"The clinical impacts of pretreatment peripheral blood ratio on lymphocytes, monocytes, and neutrophils among patients with laryngeal\/hypopharyngeal cancer treated by chemoradiation\/radiation","volume":"12","author":"Chuang","year":"2020","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.jfma.2025.04.017_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1207\/S15327914nc392_8","article-title":"Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss","volume":"39","author":"McMillan","year":"2001","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jfma.2025.04.017_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0236122","article-title":"Predictors of hospital expenses and hospital stay among patients undergoing total laryngectomy: cost effectiveness analysis","volume":"15","author":"Tsai","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jfma.2025.04.017_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/15330338221141254","article-title":"The prognostic value of preoperative albumin-to-alkaline phosphatase ratio on survival outcome for patients with locally advanced oral squamous cell carcinoma","volume":"21","author":"Tsai","year":"2022","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.jfma.2025.04.017_bib13","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.jfma.2023.06.023","article-title":"The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer","volume":"122","author":"Shih","year":"2023","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jfma.2025.04.017_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00405-020-06145-x","article-title":"Retrospective study on the potential of albumin\/globulin ratio as a prognostic biomarker for oral cavity cancer patients","volume":"278","author":"Wang","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jfma.2025.04.017_bib15","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.10465","article-title":"Clinical significance of pretreatment prognostic nutritional index and lymphocyte-to-monocyte ratio in patients with advanced p16-negative oropharyngeal cancer-a retrospective study","volume":"8","author":"Tsai","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.jfma.2025.04.017_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2018-000425","article-title":"Prognostic Nutritional Index as an independent prognostic factor in locoregionally advanced squamous cell head and neck cancer","volume":"3","author":"Bruixola","year":"2018","journal-title":"ESMO Open"},{"key":"10.1016\/j.jfma.2025.04.017_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14194892","article-title":"Prognostic value of neutrophil percentage-to-albumin ratio in patients with oral cavity cancer","volume":"14","author":"Ko","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jfma.2025.04.017_bib18","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1002\/hed.27511","article-title":"Prognostic utility of neutrophil-to-albumin ratio in surgically treated oral squamous cell carcinoma","volume":"45","author":"Yu","year":"2023","journal-title":"Head Neck"},{"key":"10.1016\/j.jfma.2025.04.017_bib19","first-page":"38","article-title":"CONUT: a tool for controlling nutritional status. First validation in a hospital population","volume":"20","author":"Ignacio de Ulibarri","year":"2005","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.jfma.2025.04.017_bib20","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00408-020-00361-2","article-title":"The significance of controlling nutritional status (CONUT) score as a novel prognostic parameter in small cell lung cancer","volume":"198","author":"Yilmaz","year":"2020","journal-title":"Lung"},{"key":"10.1016\/j.jfma.2025.04.017_bib21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s10120-017-0744-3","article-title":"Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection","volume":"21","author":"Kuroda","year":"2018","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.jfma.2025.04.017_bib22","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1245\/s10434-018-6672-6","article-title":"Prognostic significance of preoperative controlling nutritional status (CONUT) score in patients undergoing hepatic resection for hepatocellular carcinoma: a multi-institutional study","volume":"25","author":"Harimoto","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jfma.2025.04.017_bib23","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00595-020-02066-8","article-title":"The Controlling Nutritional Status (CONUT) Score as a prognostic factor for obstructive colorectal cancer patients received stenting as a bridge to curative surgery","volume":"51","author":"Sato","year":"2021","journal-title":"Surg Today"},{"key":"10.1016\/j.jfma.2025.04.017_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/sjg.sjg_384_22","article-title":"The CONUT score is prognostic in esophageal cancer treated with chemoradiotherapy","volume":"29","author":"Demir","year":"2023","journal-title":"Saudi J Gastroenterol"},{"key":"10.1016\/j.jfma.2025.04.017_bib25","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1002\/hed.27206","article-title":"Controlling Nutritional Status (CONUT) score is a prognostic marker for laryngeal cancer patients with curative resection","volume":"44","author":"Lin","year":"2022","journal-title":"Head Neck"},{"key":"10.1016\/j.jfma.2025.04.017_bib26","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/lary.30568","article-title":"Prognostic value of controlling nutritional status score in advanced hypopharyngeal cancer","volume":"133","author":"Lin","year":"2023","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jfma.2025.04.017_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.996757","article-title":"Prognostic value of inflammatory biomarkers in aged patients with oral squamous cell carcinoma","volume":"13","author":"Yoshimura","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jfma.2025.04.017_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijsu.2020.04.046","article-title":"Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer: a systematic review and meta-analysis","volume":"78","author":"Takagi","year":"2020","journal-title":"Int J Surg"},{"key":"10.1016\/j.jfma.2025.04.017_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12876-019-1126-6","article-title":"Prognostic significance of the controlling nutritional status (CONUT) score in patients undergoing hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis","volume":"19","author":"Takagi","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jfma.2025.04.017_bib30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12937-023-00863-8","article-title":"Prognostic and clinicopathological impacts of Controlling Nutritional Status (CONUT) score on patients with gynecological cancer: a meta-analysis","volume":"22","author":"Niu","year":"2023","journal-title":"Nutr J"},{"key":"10.1016\/j.jfma.2025.04.017_bib31","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1080\/01635581.2022.2059091","article-title":"The controlling nutritional status (CONUT) score and prognosis in malignant tumors: a systematic review and meta-analysis","volume":"74","author":"Chen","year":"2022","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jfma.2025.04.017_bib32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1186\/s12885-018-4616-y","article-title":"Preoperative controlling nutritional status (CONUT) score as a predictor of long-term outcome after curative resection followed by adjuvant chemotherapy in stage II-III gastric Cancer","volume":"18","author":"Liu","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jfma.2025.04.017_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3254581","article-title":"Controlling nutritional status (CONUT) as a novel postoperative prognostic marker in breast cancer patients: a retrospective study","volume":"2022","author":"Zhu","year":"2022","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jfma.2025.04.017_bib34","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1186\/s12885-019-6218-8","article-title":"Controlling nutritional status (CONUT) score as a preoperative risk assessment index for older patients with colorectal cancer","volume":"19","author":"Ahiko","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jfma.2025.04.017_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12957-024-03505-3","article-title":"Prognostic and clinicopathological value of the controlling nutritional status (CONUT) score in patients with head and neck cancer: a meta-analysis","volume":"22","author":"Wang","year":"2024","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.jfma.2025.04.017_bib36","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.0845","article-title":"Evaluation of absolute lymphocyte count at diagnosis and mortality among patients with localized bone or soft tissue sarcoma","volume":"4","author":"Brewster","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jfma.2025.04.017_bib37","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3748\/wjg.v21.i9.2668","article-title":"Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer","volume":"21","author":"Eo","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jfma.2025.04.017_bib38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10549-022-06748-4","article-title":"Absolute lymphocyte count decreases with disease progression and is a potential prognostic marker for metastatic breast cancer","volume":"196","author":"Jimbo","year":"2022","journal-title":"Breast Cancer Res Treat"},{"issue":"388","key":"10.1016\/j.jfma.2025.04.017_bib39","first-page":"e319","article-title":"Lymphopenia is an independent predictor of inferior outcome in papillary renal cell carcinoma","volume":"33","author":"Mehrazin","year":"2015","journal-title":"Urol Oncol"},{"key":"10.1016\/j.jfma.2025.04.017_bib40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1001\/jamaoto.2020.1019","article-title":"Host factors independently associated with prognosis in patients with oral cavity cancer","volume":"146","author":"Valero","year":"2020","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jfma.2025.04.017_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8060775","article-title":"Nutritional laboratory markers in malnutrition","volume":"8","author":"Keller","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jfma.2025.04.017_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1475-2891-9-69","article-title":"Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature","volume":"9","author":"Gupta","year":"2010","journal-title":"Nutr J"},{"key":"10.1016\/j.jfma.2025.04.017_bib43","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/lary.25877","article-title":"Prognostic value of albumin in patients with head and neck cancer","volume":"126","author":"Danan","year":"2016","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jfma.2025.04.017_bib44","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4490","article-title":"Clinical impact of albumin in advanced head and neck cancer patients with free flap reconstruction-a retrospective study","volume":"6","author":"Tsai","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.jfma.2025.04.017_bib45","first-page":"797","article-title":"Nutritional screening; control of clinical undernutrition with analytical parameters","volume":"29","author":"de Ulibarri Perez","year":"2014","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.jfma.2025.04.017_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101043","article-title":"Influence of cholesterol on cancer progression and therapy","volume":"14","author":"Mayengbam","year":"2021","journal-title":"Transl Oncol"},{"key":"10.1016\/j.jfma.2025.04.017_bib47","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cca.2017.11.039","article-title":"Prognostic role of serum total cholesterol and high-density lipoprotein cholesterol in cancer survivors: a systematic review and meta-analysis","volume":"477","author":"Zhou","year":"2018","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jfma.2025.04.017_bib48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s10147-017-1172-4","article-title":"Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma","volume":"23","author":"Kang","year":"2018","journal-title":"Int J Clin Oncol"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462500186X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462500186X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:35:36Z","timestamp":1773758136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092966462500186X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S092966462500186X"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2025.04.017","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Controlling nutritional status score as a survival prognosticator in patients with head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2025.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2025, Formosan Medical Association. Published by Elsevier Taiwan LLC. All rights are reserved.","name":"copyright","label":"Copyright"}]}}