{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:16:47Z","timestamp":1788985007206,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["108-2926-I-002-002-MY4"],"award-info":[{"award-number":["108-2926-I-002-002-MY4"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2314-B-002-097-MY3"],"award-info":[{"award-number":["112-2314-B-002-097-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 114-SS0027"],"award-info":[{"award-number":["NTUH 114-SS0027"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jfma.2025.09.037","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:30:41Z","timestamp":1759991441000},"page":"1231-1238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The toxicity of hybrid techniques combining hypofractionated whole breast radiotherapy with concomitant tumor bed boost in patients with breast cancer"],"prefix":"10.1016","volume":"125","author":[{"given":"Yen-Ting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-An","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hung","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Kuang Tony","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-887X","authenticated-orcid":false,"given":"Sung-Hsin","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.jfma.2025.09.037_bib1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/94.15.1143","article-title":"Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer","volume":"94","author":"Whelan","year":"2002","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"10.1016\/j.jfma.2025.09.037_bib2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1001\/jamaoncol.2020.0449","article-title":"Association of utilization management policy with uptake of hypofractionated radiotherapy among patients with early-stage breast cancer","volume":"6","author":"Parikh","year":"2020","journal-title":"JAMA Oncol"},{"issue":"2","key":"10.1016\/j.jfma.2025.09.037_bib3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2020.09.004","article-title":"Trends in use of hypofractionated whole breast radiation in breast cancer: an analysis of the national cancer database","volume":"109","author":"Woodward","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.jfma.2025.09.037_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2025.09.037_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.breast.2019.08.001","article-title":"Meta-analysis of long-term efficacy and safety of hypofractionated radiotherapy in the treatment of early breast cancer","volume":"48","author":"Andrade","year":"2019","journal-title":"Breast"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.meddos.2014.06.007","article-title":"A planning comparison of 7 irradiation options allowed in RTOG 1005 for early-stage breast cancer","volume":"40","author":"Chen","year":"2015","journal-title":"Med Dosim"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13014-016-0701-z","article-title":"Phase II trial of hypofractionated VMAT-based treatment for early stage breast cancer: 2-year toxicity and clinical results","volume":"11","author":"De Rose","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.jfma.2025.09.037_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.compmedimag.2016.10.001","article-title":"Evaluation of 3D-CRT, IMRT and VMAT radiotherapy plans for left breast cancer based on clinical dosimetric study","volume":"54","author":"Liu","year":"2016","journal-title":"Comput Med Imag Grap"},{"issue":"3","key":"10.1016\/j.jfma.2025.09.037_bib9","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ejso.2014.12.002","article-title":"Effect of cosmetic outcome on quality of life after breast cancer surgery","volume":"41","author":"Kim","year":"2015","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"10.1016\/j.jfma.2025.09.037_bib10","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/SLA.0000000000000908","article-title":"Patient-reported quality of life and satisfaction with cosmetic outcomes after breast conservation and mastectomy with and without reconstruction: results of a survey of breast cancer survivors","volume":"261","author":"Jagsi","year":"2015","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.radonc.2008.10.017","article-title":"Phase I-II studies on accelerated IMRT in breast carcinoma: technical comparison and acute toxicity in 332 patients","volume":"90","author":"Morganti","year":"2009","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clbc.2011.09.002","article-title":"Comparative acute toxicity from whole breast irradiation using 3-week accelerated schedule with concomitant boost and the 6.5-week conventional schedule with sequential boost for early-stage breast cancer","volume":"12","author":"Chadha","year":"2012","journal-title":"Clin Breast Cancer"},{"issue":"4","key":"10.1016\/j.jfma.2025.09.037_bib13","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.ijrobp.2012.01.091","article-title":"Five-year local control in a phase II study of hypofractionated intensity modulated radiation therapy with an incorporated boost for early stage breast cancer","volume":"84","author":"Freedman","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.jfma.2025.09.037_bib14","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s12032-013-0518-7","article-title":"Five-year results of a prospective case series of accelerated hypofractionated whole breast radiation with concomitant boost to the surgical bed after conserving surgery for early breast cancer","volume":"30","author":"Cante","year":"2013","journal-title":"Med Oncol"},{"key":"10.1016\/j.jfma.2025.09.037_bib15","unstructured":"Vicini F. A Phase III trial of accelerated whole breast irradiation with hypofractionation plus concurrent boost versus standard whole breast irradiation plus sequential boost for early-stage breast cancer (RTOG 1005 protocol) (NCT01349322)."},{"issue":"2","key":"10.1016\/j.jfma.2025.09.037_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0360-3016(02)04617-5","article-title":"Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results","volume":"56","author":"Wu","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.jfma.2025.09.037_bib17","first-page":"207","article-title":"Homogeneity Index: an objective tool for assessment of conformal radiation treatments","volume":"37","author":"Kataria","year":"2012","journal-title":"J Med Phy\/Assoc Med Phys India"},{"key":"10.1016\/j.jfma.2025.09.037_bib18","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2307\/3576626","article-title":"Complication probability as assessed from dose-volume histograms","volume":"104","author":"Lyman","year":"1985","journal-title":"Radiat Res"},{"issue":"3\u20134","key":"10.1016\/j.jfma.2025.09.037_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejmp.2007.07.001","article-title":"A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy","volume":"23","author":"Gay","year":"2007","journal-title":"Phys Med"},{"key":"10.1016\/j.jfma.2025.09.037_bib20","first-page":"1100","article-title":"A generalized concept of equivalent uniform dose (EUD)","volume":"26","author":"Niemierko","year":"1999","journal-title":"Med Phys"},{"issue":"2","key":"10.1016\/j.jfma.2025.09.037_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09553009214552071","article-title":"Tumour and normal tissue responses to fractionated non-uniform dose delivery","volume":"62","author":"K\u00e4llman","year":"1992","journal-title":"Int J Radiat Biol"},{"issue":"8","key":"10.1016\/j.jfma.2025.09.037_bib22","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.3390\/curroncol30080561","article-title":"NTCP calculations of five different irradiation techniques for the treatment of thymoma","volume":"30","author":"Mazonakis","year":"2023","journal-title":"Curr Oncol"},{"key":"10.1016\/j.jfma.2025.09.037_bib23","series-title":"Sample sizes for clinical, laboratory and epidemiology studies","author":"Machin","year":"2018"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1541-0420.2005.00389.x","article-title":"The Wilcoxon signed rank test for paired comparisons of clustered data","volume":"62","author":"Rosner","year":"2006","journal-title":"Biometrics"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12874-023-02097-y","article-title":"baymedr: an R package and web application for the calculation of Bayes factors for superiority, equivalence, and non-inferiority designs","volume":"23","author":"Linde","year":"2023","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jfma.2025.09.037_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.radonc.2020.09.043","article-title":"Postoperative radiotherapy with intensity-modulated radiation therapy versus 3-dimensional conformal radiotherapy in early breast cancer: a randomized clinical trial of KROG 15-03","volume":"154","author":"Choi","year":"2021","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib27","first-page":"1","article-title":"Acute toxicity of normofractionated intensity modulated radiotherapy with simultaneous integrated boost compared to three-dimensional conformal radiotherapy with sequential boost in the adjuvant treatment of breast cancer","volume":"15","author":"Krug","year":"2020","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.1016\/j.jfma.2025.09.037_bib28","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.ijrobp.2020.12.005","volume":"109","author":"H\u00f6rner-Rieber","year":"2021","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.jfma.2025.09.037_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.radonc.2021.08.019","article-title":"Quality of life after simultaneously integrated boost with intensity-modulated versus conventional radiotherapy with sequential boost for adjuvant treatment of breast cancer: 2-year results of the multicenter randomized IMRT-MC2 trial","volume":"163","author":"Forster","year":"2021","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.jfma.2025.09.037_bib30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4048\/jbc.2013.16.3.300","article-title":"Comparison of electron and x-ray beams for tumor bed boost irradiation in breast-conserving treatment","volume":"16","author":"Park","year":"2013","journal-title":"J Breast Cancer"},{"issue":"7","key":"10.1016\/j.jfma.2025.09.037_bib31","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00066-014-0658-5","article-title":"Hypofractionation with simultaneous integrated boost for early breast cancer","volume":"190","author":"Dellas","year":"2014","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00066-020-01689-7","article-title":"Adjuvant hypofractionated radiotherapy with simultaneous integrated boost after breast-conserving surgery: results of a prospective trial","volume":"197","author":"Krug","year":"2021","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.jfma.2025.09.037_bib33","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.ijrobp.2020.07.2091","article-title":"Patient reported experience with treatment modalities and safety of adjuvant breast radiotherapy-first results of the randomized HYPOSIB\u2013study","volume":"108","author":"Dunst","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.jfma.2025.09.037_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/0973-1482.43143","article-title":"Normal tissue complication probability of fibrosis in radiotherapy of breast cancer: accelerated partial breast irradiation vs conventional external-beam radiotherapy","volume":"4","author":"Jothy Basu","year":"2008","journal-title":"J Cancer Res Therapeut"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.radonc.2009.03.003","article-title":"A randomised controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: baseline characteristics and dosimetry results","volume":"92","author":"Barnett","year":"2009","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.radonc.2008.07.011","article-title":"EORTC Radiation Oncology and Breast Cancer Groups. Impact of the boost dose of 10 Gy versus 26 Gy in patients with early stage breast cancer after a microscopically incomplete lumpectomy: 10-year results of the randomised EORTC boost trial","volume":"90","author":"Poortmans","year":"2009","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.jfma.2025.09.037_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.radonc.2013.07.006","article-title":"Normal tissue complication probability (NTCP) parameters for breast fibrosis: pooled results from two randomised trials","volume":"108","author":"Mukesh","year":"2013","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.jfma.2025.09.037_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.radonc.2005.01.005","article-title":"Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial","volume":"75","author":"Yarnold","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jfma.2025.09.037_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258186","article-title":"Long-term results of hypofractionation with concomitant boost in patients with early breast cancer: a prospective study","volume":"16","author":"Saksornchai","year":"2021","journal-title":"PLoS One"},{"issue":"10394","key":"10.1016\/j.jfma.2025.09.037_bib40","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/S0140-6736(23)00619-0","article-title":"Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial","volume":"401","author":"Coles","year":"2023","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jfma.2025.09.037_bib41","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ijrobp.2022.07.2320","article-title":"Nrg RTOG 1005: a phase III trial of hypo fractionated whole breast irradiation with concurrent boost vs. conventional whole breast irradiation plus sequential boost following lumpectomy for high risk early-stage breast cancer","volume":"114","author":"Vicini","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"10.1016\/j.jfma.2025.09.037_bib42","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jfma.2025.09.037_bib43","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/ijc.35245","article-title":"A randomized trial of early cardiotoxicity in breast cancer patients receiving postoperative IMRT with or without serial cardiac dose constraints","volume":"156","author":"Cao","year":"2025","journal-title":"Int J Cancer"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664625005212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664625005212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:49:56Z","timestamp":1788983396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664625005212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0929664625005212"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2025.09.037","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The toxicity of hybrid techniques combining hypofractionated whole breast radiotherapy with concomitant tumor bed boost in patients with breast cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2025.09.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025, Formosan Medical Association. Published by Elsevier Taiwan LLC. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}