{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:18:03Z","timestamp":1783189083252,"version":"3.54.6"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["110-L1009.110-L1010.110-L1011"],"award-info":[{"award-number":["110-L1009.110-L1010.110-L1011"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 110-S5106"],"award-info":[{"award-number":["NTUH 110-S5106"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2314-B-002-090-MY3"],"award-info":[{"award-number":["MOST 109-2314-B-002-090-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2314-B-002-280"],"award-info":[{"award-number":["110-2314-B-002-280"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2628-B-002-045-MY3"],"award-info":[{"award-number":["105-2628-B-002-045-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW111-TDU-B-221-014008"],"award-info":[{"award-number":["MOHW111-TDU-B-221-014008"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jfma.2026.04.112","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:28:49Z","timestamp":1779362929000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum and tissue IGFBP2 as a prognostic biomarker in gastric adenocarcinoma: A multi-cohort clinical validation study"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-8250","authenticated-orcid":false,"given":"Kun-Feng","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-4468","authenticated-orcid":false,"given":"Chia-Tung","family":"Shun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-1216","authenticated-orcid":false,"given":"Yi-Chia","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-3835","authenticated-orcid":false,"given":"Tzu-Chan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0266-1534","authenticated-orcid":false,"given":"Chih-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaw-Town","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Rue","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-6428","authenticated-orcid":false,"given":"Ming-Shiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-5408","authenticated-orcid":false,"given":"Jyh-Ming","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2026.04.112_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jfma.2026.04.112_bib2","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa2004413","article-title":"Trastuzumab deruxtecan in previously treated HER2-positive gastric cancer","volume":"382","author":"Shitara","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.04.112_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0140-6736(21)00797-2","article-title":"First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649)","volume":"398","author":"Janjigian","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jfma.2026.04.112_bib4","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/S0959-8049(01)00269-6","article-title":"Expression of the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs) in human gastric cancer cells","volume":"37","author":"Yi","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jfma.2026.04.112_bib5","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1007\/s13277-015-3972-3","article-title":"Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers","volume":"36","author":"Kashyap","year":"2015","journal-title":"Tumour Biol"},{"key":"10.1016\/j.jfma.2026.04.112_bib6","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2025.13574","article-title":"Insulin-like growth factor in cancer: new perspectives","author":"Wu","year":"2025","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jfma.2026.04.112_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.14764","article-title":"Association of IGF-1 and IGFBP-3 levels with gastric cancer: a systematic review and meta-analysis","author":"Liu","year":"2021","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.jfma.2026.04.112_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ecl.2012.04.014","article-title":"The insulin-like growth factor system in cancer","volume":"41","author":"Weroha","year":"2012","journal-title":"Endocrinol Metab Clin N Am"},{"key":"10.1016\/j.jfma.2026.04.112_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41388-022-02353-3","article-title":"Noncoding RNA actions through IGFs and IGF binding proteins in cancer","author":"Kerr","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.jfma.2026.04.112_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1634\/theoncologist.2007-0199","article-title":"The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer","volume":"13","author":"Ryan","year":"2008","journal-title":"Oncologist"},{"key":"10.1016\/j.jfma.2026.04.112_bib11","first-page":"211","article-title":"Insulin-like growth factor binding protein-3: relationship to the development of gastric pre-malignancy and gastric adenocarcinoma (United Kingdom)","volume":"15","author":"Zhang","year":"2004","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jfma.2026.04.112_bib12","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.ejca.2007.04.014","article-title":"A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3","volume":"43","author":"Pham","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jfma.2026.04.112_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s10620-006-9358-z","article-title":"Expression of IGFBP2 in gastric carcinoma and relationship with clinicopathologic parameters and cell proliferation","volume":"52","author":"Zhang","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jfma.2026.04.112_bib14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000226089","article-title":"Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer","volume":"80","author":"Ge","year":"2009","journal-title":"Digestion"},{"key":"10.1016\/j.jfma.2026.04.112_bib15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1159\/000345918","article-title":"Prognostic significance of serum levels of vascular endothelial growth factor and insulin-like growth factor-1 in advanced gastric cancer patients treated with FOLFOX chemotherapy","volume":"58","author":"Oh","year":"2012","journal-title":"Chemotherapy"},{"key":"10.1016\/j.jfma.2026.04.112_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jprot.2015.04.021","article-title":"Identification of differentially expressed serum proteins in gastric adenocarcinoma","volume":"127","author":"Subbannayya","year":"2015","journal-title":"J Proteonomics"},{"key":"10.1016\/j.jfma.2026.04.112_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.11.027","article-title":"Serum IGFBP-1 as a potential biomarker for diagnosis of early-stage upper gastrointestinal tumour","volume":"51","author":"Xu","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jfma.2026.04.112_bib18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mrrev.2016.08.007","article-title":"Insulin-like growth factor (IGF) axis in cancerogenesis","volume":"772","author":"Kasprzak","year":"2017","journal-title":"Mutat Res Rev Mutat Res"},{"key":"10.1016\/j.jfma.2026.04.112_bib19","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.3748\/wjg.v12.i39.6285","article-title":"Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation","volume":"12","author":"Shi","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jfma.2026.04.112_bib20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/PAI.0000000000001071","article-title":"Lessons learned, challenges taken, and actions made for \u201cprecision\u201d immunohistochemistry. Analysis and perspectives from the NordiQC proficiency testing program","volume":"31","author":"Nielsen","year":"2023","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.jfma.2026.04.112_bib21","article-title":"Multidimensional reference regions for insulin-like growth factor-I, insulin-like growth factor-binding protein-2 and -3 in adult men and women","author":"Mattsson","year":"2008","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jfma.2026.04.112_bib22","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1210\/jc.2009-2668","article-title":"Plasma insulin-like growth factor-binding protein-2 levels as diagnostic and prognostic biomarker of colorectal cancer","volume":"95","author":"Liou","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jfma.2026.04.112_bib23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1215\/15228517-2008-114","article-title":"Plasma IGFBP-2 levels predict clinical outcomes of patients with high-grade gliomas","volume":"11","author":"Lin","year":"2009","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.jfma.2026.04.112_bib24","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/hpb.12199","article-title":"Serum IGFBP2 and MSLN as diagnostic and prognostic biomarkers for pancreatic cancer","volume":"16","author":"Kendrick","year":"2014","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.jfma.2026.04.112_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/538019","article-title":"Insulin-like growth factor system in cancer: novel targeted therapies","volume":"2015","author":"Brahmkhatri","year":"2015","journal-title":"BioMed Res Int"},{"issue":"Suppl 2","key":"10.1016\/j.jfma.2026.04.112_bib26","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.2188\/jea.15.S120","article-title":"Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor beta-1, soluble Fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC study","volume":"15","author":"Yatsuya","year":"2005","journal-title":"J Epidemiol"},{"key":"10.1016\/j.jfma.2026.04.112_bib27","first-page":"297","article-title":"IGF-1 and IGF-1BP3 in gastric adenocarcinoma. Preliminary study","volume":"50","author":"Franciosi","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.jfma.2026.04.112_bib28","doi-asserted-by":"crossref","first-page":"10994","DOI":"10.18632\/oncotarget.14202","article-title":"Preoperative serum levels of insulin-like growth factor-binding protein 2 predict prognosis of gastric cancer patients","volume":"8","author":"Hur","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jfma.2026.04.112_bib29","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.21873\/anticanres.13411","article-title":"IGFBP1 is a predictive factor for haematogenous metastasis in patients with gastric cancer","volume":"39","author":"Sato","year":"2019","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jfma.2026.04.112_bib30","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.tranon.2015.06.001","article-title":"Clinical significance of IGFBP-3 methylation in patients with early stage gastric cancer","volume":"8","author":"Kim","year":"2015","journal-title":"Transl Oncol"},{"key":"10.1016\/j.jfma.2026.04.112_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/neuonc\/nop007","article-title":"A multigene predictor of outcome in glioblastoma","volume":"12","author":"Colman","year":"2010","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.jfma.2026.04.112_bib32","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1210\/endo.138.4.5177","article-title":"Nuclear localization of insulin-like growth factor binding protein 3 in a lung cancer cell line","volume":"138","author":"Jaques","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.jfma.2026.04.112_bib33","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/modpathol.3800637","article-title":"Insulin-like growth factor-binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types","volume":"19","author":"Wang","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jfma.2026.04.112_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrc3720","article-title":"IGF binding proteins in cancer: mechanistic and clinical insights","volume":"14","author":"Baxter","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jfma.2026.04.112_bib35","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1038\/s41388-020-1154-2","article-title":"IGFBP2: integrative hub of developmental and oncogenic signaling network","volume":"39","author":"Li","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jfma.2026.04.112_bib36","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s13277-015-4561-1","article-title":"IGF-binding protein 2 is a candidate target of therapeutic potential in cancer","volume":"37","author":"Yao","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.jfma.2026.04.112_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fendo.2018.00117","article-title":"IGF-binding proteins: why do they exist and why are there so many?","volume":"9","author":"Allard","year":"2018","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jfma.2026.04.112_bib38","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bcp.2010.06.013","article-title":"Defining the pathway to insulin-like growth factor system targeting in cancer","volume":"80","author":"Rosenzweig","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jfma.2026.04.112_bib39","doi-asserted-by":"crossref","first-page":"djv258","DOI":"10.1093\/jnci\/djv258","article-title":"A randomized Phase II\/III study of dalotuzumab in combination with cetuximab and irinotecan in chemorefractory, KRAS wild-type, metastatic colorectal cancer","volume":"107","author":"Sclafani","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jfma.2026.04.112_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mrrev.2016.09.005","article-title":"Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer","volume":"772","author":"Philippou","year":"2017","journal-title":"Mutat Res Rev Mutat Res"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462600450X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462600450X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:53:39Z","timestamp":1783187619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092966462600450X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":40,"alternative-id":["S092966462600450X"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2026.04.112","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum and tissue IGFBP2 as a prognostic biomarker in gastric adenocarcinoma: A multi-cohort clinical validation study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2026.04.112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2026, Formosan Medical Association. Published by Elsevier Taiwan LLC. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}