{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:16:26Z","timestamp":1788556586170,"version":"build-2803163510"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["115-S0142"],"award-info":[{"award-number":["115-S0142"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 115-2314-B-002-146-"],"award-info":[{"award-number":["NSTC 115-2314-B-002-146-"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-002-107-MY2"],"award-info":[{"award-number":["NSTC 113-2314-B-002-107-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jfma.2026.08.052","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:29:19Z","timestamp":1788233359000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clonal hematopoiesis and atherosclerotic cardiovascular disease: Clinical implications, biological mechanisms, and emerging therapeutic strategies"],"prefix":"10.1016","author":[{"given":"Chi-Yuan","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9252-9939","authenticated-orcid":false,"given":"Yen-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Ru","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jone","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8936-9570","authenticated-orcid":false,"given":"Yi-Lwun","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-5735","authenticated-orcid":false,"given":"Li-Tan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2026.08.052_bib1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","article-title":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the global burden of disease study 2016","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jfma.2026.08.052_bib2","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jacc.2017.01.064","article-title":"The aging cardiovascular system: understanding it at the cellular and clinical levels","volume":"69","author":"Paneni","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41569-020-0431-7","article-title":"Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6","volume":"18","author":"Tyrrell","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib4","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1093\/eurheartj\/ehv587","article-title":"Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease","volume":"36","author":"Camici","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jfma.2026.08.052_bib5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib6","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1093\/eurheartj\/ehz961","article-title":"Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease","volume":"41","author":"Liberale","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jfma.2026.08.052_bib7","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib8","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan4673","article-title":"Clonal hematopoiesis in human aging and disease","volume":"366","author":"Jaiswal","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jfma.2026.08.052_bib10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/HCO.0000000000001286","article-title":"Genetic factors contributing to atherosclerosis","volume":"41","author":"Raddatz","year":"2026","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1182\/blood-2017-07-746453","article-title":"Age-related clonal hematopoiesis","volume":"131","author":"Shlush","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.stem.2018.01.011","article-title":"Clonal hematopoiesis and evolution to hematopoietic malignancies","volume":"22","author":"Bowman","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jfma.2026.08.052_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCRESAHA.117.312115","article-title":"Somatic mutations and clonal hematopoiesis: unexpected potential new drivers of age-related cardiovascular disease","volume":"122","author":"Fuster","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jfma.2026.08.052_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s44161-021-00015-3","article-title":"Clonal hematopoiesis in cardiovascular disease and therapeutic implications","volume":"1","author":"Tall","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jfma.2026.08.052_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180066","article-title":"Clonal hematopoiesis and atherosclerosis","volume":"134","author":"Oren","year":"2024","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jfma.2026.08.052_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.200334","article-title":"Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis","volume":"11","author":"Carter","year":"2026","journal-title":"JCI Insight"},{"key":"10.1016\/j.jfma.2026.08.052_bib18","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41569-025-01148-9","article-title":"Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target","volume":"22","author":"Schuermans","year":"2025","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00004.2022","article-title":"Clonal hematopoiesis, somatic mosaicism, and age-associated disease","volume":"103","author":"Evans","year":"2023","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jfma.2026.08.052_bib20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2012.06.023","article-title":"The origin and evolution of mutations in acute myeloid leukemia","volume":"150","author":"Welch","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jfma.2026.08.052_bib21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-018-0497-0","article-title":"Population dynamics of normal human blood inferred from somatic mutations","volume":"561","author":"Lee-Six","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2026.08.052_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180065","article-title":"Clonal hematopoiesis and hematological malignancy","volume":"134","author":"Dunn","year":"2024","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jfma.2026.08.052_bib24","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib25","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.118.001926","article-title":"Clonal hematopoiesis: somatic mutations in blood cells and atherosclerosis","volume":"11","author":"Natarajan","year":"2018","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib26","first-page":"1590","article-title":"Clonal hematopoiesis: mechanisms driving dominance of stem cell clones","volume":"136","author":"Challen","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13366","article-title":"Clonal hematopoiesis associated with epigenetic aging and clinical outcomes","volume":"20","author":"Nachun","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.jfma.2026.08.052_bib28","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and Histiocytic\/Dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.jfma.2026.08.052_bib29","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.celrep.2015.02.005","article-title":"Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis","volume":"10","author":"McKerrell","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jfma.2026.08.052_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12484","article-title":"Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults","volume":"7","author":"Young","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jfma.2026.08.052_bib31","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41586-018-0317-6","article-title":"Prediction of acute myeloid leukaemia risk in healthy individuals","volume":"559","author":"Abelson","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2026.08.052_bib32","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/s41588-022-01121-z","article-title":"Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis","volume":"54","author":"Kar","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.jfma.2026.08.052_bib33","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/s41591-018-0081-z","article-title":"Somatic mutations precede acute myeloid leukemia years before diagnosis","volume":"24","author":"Desai","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib34","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood.2021011323","article-title":"Relationship between clone metrics and clinical outcome in clonal cytopenia","volume":"138","author":"Gall\u00ec","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib35","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1182\/blood-2017-01-763425","article-title":"Clinical significance of somatic mutation in unexplained blood cytopenia","volume":"129","author":"Malcovati","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib36","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2024024756","article-title":"Risk prediction for clonal cytopenia: multicenter real-world evidence","volume":"144","author":"Xie","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib37","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2200310","article-title":"Prediction of risk for myeloid malignancy in clonal hematopoiesis","volume":"2","author":"Weeks","year":"2023","journal-title":"NEJM Evid"},{"key":"10.1016\/j.jfma.2026.08.052_bib38","first-page":"1606","article-title":"Clonal hematopoiesis and nonhematologic disorders","volume":"136","author":"Jaiswal","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-med-042921-112347","article-title":"Clonal hematopoiesis and its impact on human health","volume":"74","author":"Ahmad","year":"2023","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1182\/blood.2021013531","article-title":"Association of clonal hematopoiesis with chronic obstructive pulmonary disease","volume":"139","author":"Miller","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1053\/j.ajkd.2022.08.014","article-title":"Clonal hematopoiesis of indeterminate potential and kidney function decline in the general population","volume":"81","author":"Kestenbaum","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jfma.2026.08.052_bib42","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.2337\/dc23-0805","article-title":"Clonal hematopoiesis of indeterminate potential (CHIP) and incident type 2 diabetes risk","volume":"46","author":"Tobias","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jfma.2026.08.052_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.70137","article-title":"Clonal haematopoiesis in type 2 diabetes: a review of mechanistic links with inflammation and cardiovascular disease","volume":"42","author":"Migliozzi","year":"2026","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.jfma.2026.08.052_bib44","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41586-023-05857-4","article-title":"Clonal haematopoiesis and risk of chronic liver disease","volume":"616","author":"Wong","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2026.08.052_bib45","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/HEP.0000000000000839","article-title":"Impact of clonal hematopoiesis of indeterminate potential on hepatocellular carcinoma in individuals with steatotic liver disease","volume":"80","author":"Marchetti","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.jfma.2026.08.052_bib46","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1182\/blood.2022015384","article-title":"TET2-mutant clonal hematopoiesis and risk of gout","volume":"140","author":"Agrawal","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib47","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211872","article-title":"Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis","volume":"218","author":"Kim","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib48","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/joim.20080","article-title":"Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases","volume":"297","author":"Wu","year":"2025","journal-title":"J Intern Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.seminhematol.2024.01.012","article-title":"Clonal hematopoiesis and autoimmunity","volume":"61","author":"Kishtagari","year":"2024","journal-title":"Semin Hematol"},{"key":"10.1016\/j.jfma.2026.08.052_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12916-025-04077-z","article-title":"Clonal hematopoiesis of indeterminate potential and risk of autoimmune thyroid disease","volume":"23","author":"Zhang","year":"2025","journal-title":"BMC Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib51","article-title":"Clonal haematopoiesis and risk of incident rheumatoid arthritis: results from the UK biobank","author":"Cui","year":"2026","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jfma.2026.08.052_bib52","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1038\/s41591-024-03188-z","article-title":"Clonal hematopoiesis, cardiovascular events and treatment benefit in 63,700 individuals from five TIMI randomized trials","volume":"30","author":"Marston","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib53","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1182\/bloodadvances.2024013228","article-title":"Clonal hematopoiesis of indeterminate potential as a prognostic factor: a systematic review and meta-analysis","volume":"8","author":"Singh","year":"2024","journal-title":"Blood Adv"},{"key":"10.1016\/j.jfma.2026.08.052_bib54","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/CIRCULATIONAHA.120.051775","article-title":"Premature menopause, clonal hematopoiesis, and coronary artery disease in postmenopausal women","volume":"143","author":"Honigberg","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2026.08.052_bib55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jaccao.2021.01.001","article-title":"Clonal hematopoiesis and JAK2V617F mutations in patients with cardiovascular disease","volume":"3","author":"Yokokawa","year":"2021","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jfma.2026.08.052_bib56","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1161\/CIRCULATIONAHA.122.062126","article-title":"Interleukin-6 receptor polymorphism attenuates clonal hematopoiesis-mediated coronary artery disease risk among 451 180 individuals in the UK biobank","volume":"147","author":"Vlasschaert","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2026.08.052_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109472","article-title":"Clonal hematopoiesis is associated with cardiovascular events in patients with stable coronary artery disease","volume":"27","author":"Dregoesc","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jfma.2026.08.052_bib58","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.jacc.2023.03.401","article-title":"Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease","volume":"81","author":"Gumuser","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib59","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.jacc.2022.08.740","article-title":"Impact of clonal hematopoiesis in patients with cardiogenic shock complicating acute myocardial infarction","volume":"80","author":"B\u00f6hme","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103964","article-title":"Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction","volume":"78","author":"Wang","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jfma.2026.08.052_bib61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12933-025-02588-w","article-title":"Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization","volume":"24","author":"Zhao","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jfma.2026.08.052_bib62","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jacc.2021.04.085","article-title":"Supplemental association of clonal hematopoiesis with incident heart failure","volume":"78","author":"Yu","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib63","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ejhf.2715","article-title":"Clonal haematopoiesis of indeterminate potential: associations with heart failure incidence, clinical parameters and biomarkers","volume":"25","author":"Shi","year":"2023","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jfma.2026.08.052_bib64","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.53244","article-title":"Clonal hematopoiesis and incident heart failure with preserved ejection fraction","volume":"7","author":"Schuermans","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jfma.2026.08.052_bib65","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.120.003003","article-title":"Multiple somatic mutations for clonal hematopoiesis are associated with increased mortality in patients with chronic heart failure","volume":"13","author":"Cremer","year":"2020","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib66","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/CIRCULATIONAHA.123.064170","article-title":"Clonal hematopoiesis in clinical and experimental heart failure with preserved ejection fraction","volume":"148","author":"Cochran","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2026.08.052_bib67","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jacc.2025.07.058","article-title":"Clonal hematopoiesis and cardiovascular outcomes in older women","volume":"86","author":"Ezzat","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib68","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.jacc.2021.02.028","article-title":"Clonal hematopoiesis and risk of progression of heart failure with reduced left ventricular ejection fraction","volume":"77","author":"Pascual-Figal","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/jamacardio.2018.3965","article-title":"Association of mutations contributing to clonal hematopoiesis with prognosis in chronic ischemic heart failure","volume":"4","author":"Dorsheimer","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib70","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/eurheartj\/ehaa845","article-title":"Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations","volume":"42","author":"Assmus","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jfma.2026.08.052_bib71","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/ehf2.13297","article-title":"Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality","volume":"8","author":"Kiefer","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jfma.2026.08.052_bib72","doi-asserted-by":"crossref","DOI":"10.1172\/JCI171634","article-title":"Clonal hematopoiesis activates procalcific pathways in macrophages and promotes aortic valve stenosis","volume":"136","author":"Abplanalp","year":"2026","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jfma.2026.08.052_bib73","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/eurheartj\/ehz591","article-title":"Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation","volume":"41","author":"Mas-Peiro","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jfma.2026.08.052_bib74","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00392-022-02135-7","article-title":"Long-term risk associated with clonal hematopoiesis in patients with severe aortic valve stenosis undergoing TAVR","volume":"112","author":"Mas-Peiro","year":"2023","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101532","article-title":"Clonal hematopoiesis is associated with adverse clinical outcomes and left ventricular remodeling in aortic stenosis","volume":"4","author":"Yao","year":"2025","journal-title":"JACC Adv"},{"key":"10.1016\/j.jfma.2026.08.052_bib76","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.jacbts.2023.04.010","article-title":"Negative impact of TET2 mutations on long-term survival after transcatheter aortic valve replacement","volume":"8","author":"Lassalle","year":"2023","journal-title":"JACC, Basic Transl Sci"},{"key":"10.1016\/j.jfma.2026.08.052_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-24130-8","article-title":"Transcriptomic profiling of calcified aortic valves in clonal hematopoiesis of indeterminate potential carriers","volume":"12","author":"Vieceli Dalla Sega","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.jfma.2026.08.052_bib78","doi-asserted-by":"crossref","DOI":"10.1007\/s00392-025-02658-9","article-title":"Mutational landscape and impact of clonal hematopoiesis of indeterminate potential in severe aortic valve stenosis","author":"Jamin","year":"2025","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib79","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/jamacardio.2020.2468","article-title":"Association of clonal hematopoiesis of indeterminate potential with inflammatory gene expression in patients with severe degenerative aortic valve stenosis or chronic postischemic heart failure","volume":"5","author":"Abplanalp","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib80","first-page":"819","article-title":"Cell-intrinsic effects of clonal hematopoiesis in heart failure","volume":"2","author":"Abplanalp","year":"2023","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jfma.2026.08.052_bib81","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCRESAHA.120.317104","article-title":"Clonal hematopoiesis-driver DNMT3A mutations alter immune cells in heart failure","volume":"128","author":"Abplanalp","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jfma.2026.08.052_bib82","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","article-title":"Tet2-Mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1\u03b2\/NLRP3 inflammasome","volume":"71","author":"Sano","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib83","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1161\/CIRCULATIONAHA.123.065344","article-title":"BRCC3-Mediated NLRP3 deubiquitylation promotes inflammasome activation and atherosclerosis in Tet2 clonal hematopoiesis","volume":"148","author":"Yalcinkaya","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2026.08.052_bib84","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1001\/jamacardio.2022.0386","article-title":"TET2-Driven clonal hematopoiesis and response to canakinumab: an exploratory analysis of the CANTOS randomized clinical trial","volume":"7","author":"Svensson","year":"2022","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib85","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.atherosclerosis.2022.03.005","article-title":"Blocking the NLRP3 inflammasome reduces osteogenic calcification and M1 macrophage polarization in a mouse model of calcified aortic valve stenosis","volume":"347","author":"Lu","year":"2022","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jfma.2026.08.052_bib86","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026154","article-title":"Experimental ASXL1-Mediated clonal hematopoiesis promotes inflammation and accelerates heart failure","volume":"11","author":"Min","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jfma.2026.08.052_bib87","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/s44161-024-00579-w","article-title":"Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity","volume":"3","author":"Sato","year":"2024","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jfma.2026.08.052_bib88","doi-asserted-by":"crossref","first-page":"E1490","DOI":"10.1073\/pnas.1616420114","article-title":"Dnmt3a restrains mast cell inflammatory responses","volume":"114","author":"Leoni","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfma.2026.08.052_bib89","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ng.1009","article-title":"Dnmt3a is essential for hematopoietic stem cell differentiation","volume":"44","author":"Challen","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.jfma.2026.08.052_bib90","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41586-021-03341-5","article-title":"The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis","volume":"592","author":"Fidler","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2026.08.052_bib91","article-title":"Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice","volume":"135","author":"Liu","year":"2024","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jfma.2026.08.052_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132184","article-title":"The clonal hematopoiesis mutation Jak2(V617F) aggravates endothelial injury and thrombosis in arteries with erosion-like intimas","volume":"409","author":"Molinaro","year":"2024","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib93","doi-asserted-by":"crossref","first-page":"e650","DOI":"10.1016\/S2352-3026(25)00137-1","article-title":"Clonal haematopoiesis to clonal cytopenias: unravelling disease evolution over time","volume":"12","author":"Kirschner","year":"2025","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jfma.2026.08.052_bib94","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1161\/CIRCULATIONAHA.119.044362","article-title":"Genetic interleukin 6 signaling deficiency attenuates cardiovascular risk in clonal hematopoiesis","volume":"141","author":"Bick","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jfma.2026.08.052_bib95","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib96","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in patients with chronic coronary disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.08.052_bib97","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.atherosclerosis.2017.12.027","article-title":"The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation","volume":"269","author":"Mart\u00ednez","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jfma.2026.08.052_bib98","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.jacc.2025.08.025","article-title":"Colchicine and longitudinal dynamics of clonal hematopoiesis: an exploratory substudy of the LoDoCo2 trial","volume":"86","author":"Mohammadnia","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jfma.2026.08.052_bib99","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10557-020-06943-9","article-title":"Inhibition of JAK2 suppresses myelopoiesis and atherosclerosis in Apoe(-\/-) mice","volume":"34","author":"Tang","year":"2020","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jfma.2026.08.052_bib100","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1182\/blood-2014-06-582809","article-title":"TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients","volume":"124","author":"Bejar","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib101","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.3324\/haematol.2016.148999","article-title":"Mutational correlates of response to hypomethylating agent therapy in acute myeloid leukemia","volume":"101","author":"Coombs","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.jfma.2026.08.052_bib102","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2023-184977","article-title":"Ivosidenib for patients with clonal cytopenia of undetermined significance and mutations in IDH1","volume":"142","author":"Petrone","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jfma.2026.08.052_bib103","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41586-025-08871-w","article-title":"Metformin reduces the competitive advantage of Dnmt3a(R878H) HSPCs","volume":"642","author":"Hosseini","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jfma.2026.08.052_bib104","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1158\/2643-3230.BCD-21-0143","article-title":"The cell type-specific 5hmC landscape and dynamics of healthy human hematopoiesis and TET2-Mutant preleukemia","volume":"3","author":"Nakauchi","year":"2022","journal-title":"Blood Cancer Discov"},{"key":"10.1016\/j.jfma.2026.08.052_bib105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s42003-020-01220-9","article-title":"Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia","volume":"3","author":"Guan","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.jfma.2026.08.052_bib106","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s44161-022-00206-6","article-title":"TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease","volume":"2","author":"Zekavat","year":"2023","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jfma.2026.08.052_bib107","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jaccao.2025.05.013","article-title":"Managing cardiovascular risk in clonal hematopoiesis of indeterminate potential: JACC: cardiooncology short-form primer","volume":"7","author":"Oren","year":"2025","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.jfma.2026.08.052_bib108","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13148-022-01404-6","article-title":"Vitamin C boosts DNA demethylation in TET2 germline mutation carriers","volume":"15","author":"Taira","year":"2023","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.jfma.2026.08.052_bib109","doi-asserted-by":"crossref","first-page":"e940","DOI":"10.1161\/CIR.0000000000001404","article-title":"Clonal hematopoiesis and its cardiovascular implications: a scientific statement from the American heart Association","volume":"153","author":"Rhee","year":"2026","journal-title":"Circulation"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664626008417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0929664626008417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:06:08Z","timestamp":1788555968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0929664626008417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":109,"alternative-id":["S0929664626008417"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2026.08.052","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clonal hematopoiesis and atherosclerotic cardiovascular disease: Clinical implications, biological mechanisms, and emerging therapeutic strategies","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2026.08.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2026, Formosan Medical Association. Published by Elsevier Taiwan LLC. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}