{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:03:18Z","timestamp":1789646598926,"version":"4.0.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-002-228"],"award-info":[{"award-number":["NSTC 112-2314-B-002-228"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114-2314-B-002-182"],"award-info":[{"award-number":["114-2314-B-002-182"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2314-B-002-123"],"award-info":[{"award-number":["113-2314-B-002-123"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Formosan Medical Association"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jfma.2026.08.058","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:38:58Z","timestamp":1788320338000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical predictors of severe and fatal respiratory syncytial virus infection in adults and the elderly: A retrospective cohort study"],"prefix":"10.1016","author":[{"given":"Yen-Chieh","family":"Chin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6324-1135","authenticated-orcid":false,"given":"Li-Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yuan","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-1699","authenticated-orcid":false,"given":"Chi-Tai","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-1956","authenticated-orcid":false,"given":"Luan-Yin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfma.2026.08.058_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijid.2023.08.008","article-title":"Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: a systematic analysis of the global Burden of Disease 2019 Study","volume":"135","author":"Du","year":"2023","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib2","first-page":"478","article-title":"RSV vaccination as the optimal prevention strategy for older adults","volume":"32","author":"Andreoni","year":"2024","journal-title":"Infez Med"},{"key":"10.1016\/j.jfma.2026.08.058_bib3","doi-asserted-by":"crossref","first-page":"ofae513","DOI":"10.1093\/ofid\/ofae513","article-title":"Clinical manifestations and outcomes in adults hospitalized with respiratory syncytial virus and influenza a\/B: a multicenter observational cohort Study","volume":"11","author":"Clausen","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib4","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa043951","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults","volume":"352","author":"Falsey","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.08.058_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/infdis\/jis309","article-title":"Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults","volume":"206","author":"Widmer","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib6","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1056\/NEJMoa2309189","article-title":"Nirsevimab for prevention of hospitalizations due to RSV in infants","volume":"389","author":"Drysdale","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfma.2026.08.058_bib7","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001545","article-title":"Viral respiratory tract infections in adult patients attending outpatient and emergency departments, Taiwan, 2012-2013: a PCR\/Electrospray ionization Mass spectrometry Study","volume":"94","author":"Shih","year":"2015","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jfma.2026.08.058_bib8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/vaccines11050905","article-title":"Viral pneumonia during the COVID-19 pandemic, 2019-2021 evoking needs for SARS-CoV-2 and additional vaccinations","volume":"11","author":"Lin","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jfma.2026.08.058_bib9","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jfma.2023.12.004","article-title":"Epidemiology and clinical characteristics of hospitalized adults with respiratory syncytial virus infection at a medical center in northern Taiwan","volume":"123","author":"Chang","year":"2024","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jfma.2026.08.058_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99608-y","article-title":"Respiratory viral infections in pragmatically selected adults in intensive care units","volume":"11","author":"Cia","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jfma.2026.08.058_bib11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.15585\/mmwr.mm7332e1","article-title":"Use of respiratory syncytial virus vaccines in adults aged \u226560 years: updated Recommendations of the Advisory Committee on immunization practices - united States, 2024","volume":"73","author":"Britton","year":"2024","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jfma.2026.08.058_bib12","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3390\/microorganisms9061293","article-title":"Bacterial and viral coinfections with the human respiratory syncytial virus","volume":"9","author":"Pacheco","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.jfma.2026.08.058_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12916-023-03100-5","article-title":"Transient increased risk of influenza infection following RSV infection in South Africa: findings from the PHIRST study, South Africa, 2016\u20132018","volume":"21","author":"Waterlow","year":"2023","journal-title":"BMC Med"},{"key":"10.1016\/j.jfma.2026.08.058_bib14","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/cid\/ciaa1728","article-title":"Impact of the coronavirus disease 2019 (COVID-19) pandemic on invasive pneumococcal disease and risk of pneumococcal coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): prospective national cohort Study, England","volume":"72","author":"Amin-Chowdhury","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2020.104685","article-title":"Severity of influenza virus and respiratory syncytial virus coinfections in hospitalized adult patients","volume":"133","author":"Zhang","year":"2020","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jfma.2026.08.058_bib16","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1097\/INF.0000000000004080","article-title":"Clinical relevance of RSV and SARS-CoV-2 coinfections in infants and young children","volume":"42","author":"Rodriguez-Fernandez","year":"2023","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jfma.2026.08.058_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10096-018-3407-3","article-title":"Microorganisms associated with respiratory syncytial virus pneumonia in the adult population","volume":"38","author":"Jeanno\u00ebl","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.100955","article-title":"Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients","volume":"37","author":"Liu","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jfma.2026.08.058_bib19","doi-asserted-by":"crossref","first-page":"943.e1","DOI":"10.1016\/j.cmi.2023.03.003","article-title":"Prognosis of hospitalised adult patients with respiratory syncytial virus infection: a multicentre retrospective cohort study","volume":"29","author":"Celante","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jfma.2026.08.058_bib20","doi-asserted-by":"crossref","first-page":"ofaa546","DOI":"10.1093\/ofid\/ofaa546","article-title":"Respiratory syncytial virus infection: its propensity for bacterial coinfection and related mortality in elderly adults","volume":"7","author":"Godefroy","year":"2020","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib21","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/jmv.21623","article-title":"Respiratory syncytial virus infection facilitates acute colonization of Pseudomonas aeruginosa in mice","volume":"81","author":"de Vrankrijker","year":"2009","journal-title":"J Med Virol"},{"key":"10.1016\/j.jfma.2026.08.058_bib22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jointm.2024.03.001","article-title":"Severe respiratory syncytial virus disease","volume":"4","author":"Pe\u00f1a-L\u00f3pez","year":"2024","journal-title":"J Intensive Med"},{"key":"10.1016\/j.jfma.2026.08.058_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2023.105399","article-title":"Focusing on severe infections with the respiratory syncytial virus (RSV) in adults: risk factors, symptomatology and clinical course compared to influenza A\/B and the original SARS-CoV-2 strain","volume":"161","author":"Ambrosch","year":"2023","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jfma.2026.08.058_bib24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.15585\/mmwr.mm7240a2","article-title":"Disease severity of respiratory syncytial virus compared with COVID-19 and Influenza among hospitalized adults aged \u226560 years - IVY network, 20 U.S. States, February 2022-May 2023","volume":"72","author":"Surie","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jfma.2026.08.058_bib25","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1093\/cid\/ciaa730","article-title":"Respiratory syncytial virus-associated hospitalizations among adults with chronic medical conditions","volume":"73","author":"Prasad","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1231641","article-title":"Diabetes and bacterial co-infection are two independent risk factors for respiratory syncytial virus disease severity","volume":"10","author":"Sivgin","year":"2023","journal-title":"Front Med"},{"key":"10.1016\/j.jfma.2026.08.058_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155539","article-title":"Hyperglycemia results in decreased immune cell infiltration and increased viral load in the lung in a mouse model of RSV infection","volume":"143","author":"Khodakhah","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.jfma.2026.08.058_bib28","doi-asserted-by":"crossref","first-page":"ofad513","DOI":"10.1093\/ofid\/ofad513","article-title":"Systematic literature review of risk factors for poor outcomes among adults with respiratory syncytial virus infection in high-income countries","volume":"10","author":"Njue","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/tid.12994","article-title":"Risk factors for mortality after respiratory syncytial virus lower respiratory tract infection in adults with hematologic malignancies","volume":"20","author":"Vakil","year":"2018","journal-title":"Transpl Infect Dis"},{"issue":"Supplement_1","key":"10.1016\/j.jfma.2026.08.058_bib30","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1093\/infdis\/jiad510","article-title":"Respiratory syncytial virus-associated hospitalization in adults with comorbidities in 2 European countries: a modeling Study","volume":"229","author":"Osei-Yeboah","year":"2024","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib31","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/infdis\/jiae346","article-title":"Relative contribution of diagnostic testing to the diagnosis of respiratory syncytial virus in hospitalized adults in the United States","volume":"230","author":"Anderson","year":"2024","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfma.2026.08.058_bib32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1017\/ice.2022.128","article-title":"Clinical impact of healthcare-associated respiratory syncytial virus in hospitalized adults","volume":"44","author":"Hill-Ricciuti","year":"2023","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jfma.2026.08.058_bib33","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/irv.12379","article-title":"Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review","volume":"10","author":"French","year":"2016","journal-title":"Influenza Other Respir Viruses"}],"container-title":["Journal of the Formosan Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462600865X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092966462600865X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:29:48Z","timestamp":1789644588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092966462600865X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S092966462600865X"],"URL":"https:\/\/doi.org\/10.1016\/j.jfma.2026.08.058","relation":{},"ISSN":["0929-6646"],"issn-type":[{"value":"0929-6646","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical predictors of severe and fatal respiratory syncytial virus infection in adults and the elderly: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Formosan Medical Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfma.2026.08.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2026, Formosan Medical Association. Published by Elsevier Taiwan LLC. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}