{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:29:23Z","timestamp":1777850963293,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>This case report documents clinical and molecular findings in two littermate kittens of the Japanese domestic cat with GM2 gangliosidosis variant 0. Analysis included detailed physical, magnetic resonance imaging, biochemical, pathological and genetic examinations. At first, these littermate kittens showed typical cerebellar signs at approximately 2 months of age. About 2 months later, they progressively showed other neurological signs and subsequently died at about 7 months of age. Magnetic resonance imaging just before the death showed an enlarged ventricular system, T1 hyperintensity in the internal capsule, and T2 hyperintensity in the white matter of the whole brain. Histological findings suggested a type of lysosomal storage disease. Biochemical studies demonstrated that the kittens were affected with GM2 gangliosidosis variant 0, and a DNA assay finally demonstrated that these animals were homozygous for the mutation, which the authors had identified in a different family of the Japanese domestic cat. The findings in the present cases provide\u00a0useful information about GM2 gangliosidosis variant 0 in Japanese domestic cats.<\/jats:p>","DOI":"10.1016\/j.jfms.2006.11.003","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T08:26:01Z","timestamp":1167899161000},"page":"232-237","source":"Crossref","is-referenced-by-count":19,"title":["Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat"],"prefix":"10.1177","volume":"9","author":[{"given":"Daisuke","family":"Hasegawa","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yamato","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Fujita","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimimasa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Satoh","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Shoda","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimitsu","family":"Maede","sequence":"additional","affiliation":[{"name":"Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Kita-ku, Sapporo 060-0818, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Arai","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Orima","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounan-chou, Musashino-shi, Tokyo 180-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"bibr1-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687364"},{"key":"bibr2-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1126\/science.404709"},{"key":"bibr3-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687809"},{"key":"bibr4-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050955"},{"key":"bibr5-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197001000-00044"},{"key":"bibr6-j.jfms.2006.11.003","first-page":"3827","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Gravel R.A.","year":"2001","edition":"8"},{"key":"bibr7-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0925-3"},{"key":"bibr8-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2006.05.007"},{"key":"bibr9-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588086"},{"key":"bibr10-j.jfms.2006.11.003","first-page":"1219","volume":"16","author":"Kroll R.A.","year":"1995","journal-title":"American Journal of Neuroradiology"},{"key":"bibr11-j.jfms.2006.11.003","first-page":"219","volume-title":"Handbook of Veterinary Neurology","author":"Lorenz M.D.","year":"2004","edition":"4"},{"key":"bibr12-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50113-0"},{"key":"bibr13-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.008"},{"key":"bibr14-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1040-6"},{"key":"bibr15-j.jfms.2006.11.003","first-page":"275","volume":"46","author":"Matsuki N.","year":"2005","journal-title":"Canadian Veterinary Journal"},{"key":"bibr16-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199607000-00009"},{"key":"bibr17-j.jfms.2006.11.003","first-page":"1109","volume":"144","author":"Muldoon L.L.","year":"1994","journal-title":"American Journal of Pathology"},{"key":"bibr18-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111997"},{"key":"bibr19-j.jfms.2006.11.003","first-page":"419","volume":"83","author":"Pierce K.R.","year":"1976","journal-title":"American Journal of Pathology"},{"key":"bibr20-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1177\/030098586800500108"},{"key":"bibr21-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1177\/104063870401600308"},{"key":"bibr22-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(78)50049-9"},{"key":"bibr23-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016562626961"},{"key":"bibr24-j.jfms.2006.11.003","first-page":"739","volume":"155","author":"Yamato O.","year":"2004","journal-title":"Veterinary Record"},{"key":"bibr26-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1136\/vr.146.17.493"},{"key":"bibr25-j.jfms.2006.11.003","doi-asserted-by":"publisher","DOI":"10.1177\/104063870401600107"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.jfms.2006.11.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1016\/j.jfms.2006.11.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.jfms.2006.11.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:14:24Z","timestamp":1777500864000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1016\/j.jfms.2006.11.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1016\/j.jfms.2006.11.003"],"URL":"https:\/\/doi.org\/10.1016\/j.jfms.2006.11.003","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}