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Mean thermal thresholds did not change significantly [analysis of variance (ANOVA)] from baseline. The maximum thermal threshold increase above baseline was 2.8\u00b12.8\u00b0C at 6 h ( P&gt;0.05) after tramadol; it was above the 95% confidence interval (CI) at 0.75, 3 and 6 h. Pressure thresholds increased above baseline from 0.25 to 2 h after acepromazine ( P&lt;0.05) and from 0.5 to 3 h after the combination ( P&lt;0.05), with a maximum increase of 132\u00b1156 mmHg 0.25 h after acepromazine and 197\u00b1129 mmHg 0.5 h after the combination. Pressure thresholds were above the 95% CI from 0.25 to 2 h after acepromazine and from 0.5 to 3 h after the combination. SC tramadol at 1 mg\/kg in cats had limited effect on thermal and pressure nociception, but this was enhanced by acepromazine. Acepromazine alone had pressure antinociceptive effects.<\/jats:p>","DOI":"10.1016\/j.jfms.2007.06.009","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T07:29:19Z","timestamp":1188977359000},"page":"24-31","source":"Crossref","is-referenced-by-count":78,"title":["Antinociceptive effects of tramadol and acepromazine in cats"],"prefix":"10.1177","volume":"10","author":[{"given":"Paulo V.M.","family":"Steagall","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science, FMVZ, UNESP, Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polly M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Taylor Monroe, Gravel Head Farm, Downham Common, Little Downham, Ely, Cambs CB6 2TY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana T.","family":"Brondani","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science, FMVZ, UNESP, Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stelio P.L.","family":"Luna","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine and Animal Science, FMVZ, UNESP, Botucatu, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Taylor Monroe, Gravel Head Farm, Downham Common, Little Downham, Ely, Cambs CB6 2TY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"bibr1-j.jfms.2007.06.009","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2995.2000.00024.x"},{"key":"bibr2-j.jfms.2007.06.009","first-page":"111","volume-title":"Anaesthesia of the Cat","author":"Brearley J.C.","year":"1994","edition":"1"},{"key":"bibr3-j.jfms.2007.06.009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1998.tb00158.x"},{"key":"bibr4-j.jfms.2007.06.009","unstructured":"Brondani JT, Beier SL, Luna SPL, Minto BW, Gomes GC (2006) Analgesic effects of perioperative administration of vedaprofen, tramadol and their combination in cats undergoing ovariohysterectomy. 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