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Serial plasma samples were collected and assayed for metronidazole using high pressure liquid chromatography (HPLC). Genotoxicity was assessed in vitro in feline peripheral blood mononuclear cells (PBMC) and a feline T-cell lymphoma line incubated with metronidazole, and in vivo in PBMC collected before, during and 7 days after oral metronidazole, by use of the COMET assay. Systemic absorption of metronidazole was variable (mean=65\u00b128%) with a peak of 8.84\u00b15.4 \u03bcg\/ml at 3.6\u00b12.9 h. The terminal half-life was 5.34 h from the intravenous dose and 5.16 h from the oral dose. Systemic clearance was low (mean=91.57 ml\/h\/kg [1.53 ml\/kg\/min]), and the apparent volume of distribution (steady state) was 0.650\u00b10.254 l\/kg. Genotoxicity was detected at all concentrations of metronidazole in feline PBMC and the T-cell lymphoma line in vitro. Genotoxicity was also observed in PBMC collected from cats after 7 days of oral metronidazole but resolved within 6 days of discontinuing metronidazole.<\/jats:p>","DOI":"10.1016\/j.jfms.2008.06.011","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T04:05:27Z","timestamp":1232424327000},"page":"60-68","source":"Crossref","is-referenced-by-count":32,"title":["Single-dose pharmacokinetics and genotoxicity of metronidazole in cats"],"prefix":"10.1177","volume":"11","author":[{"given":"Ivana","family":"Sekis","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Tower Road, Ithaca, NY 14853, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Ramstead","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Tower Road, Ithaca, NY 14853, United 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