{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:33:49Z","timestamp":1780396429478,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>In this report, multiple abnormalities (bilateral ovarian cysts, cystic endometrial hyperplasia and pyometra (CEH\u2013P), mammary adenoma, fibrosarcoma and cystic-papillary adenocarcinoma) identified in a queen continually administered medroxyprogesterone acetate (MPA) for 9 years are described. An 11-year-old domestic shorthair intact queen was presented for reduced appetite, polyuria, polydipsia, abdominal distension, and mammary mass. Pyometra was diagnosed based upon clinical, ultrasonographic and radiographic examinations. Mastectomy and ovariohysterectomy (OHE) were performed for\u00a0treatment. Bilateral ovarian cysts were detected during OHE. Histopathologically, follicular ovarian cysts, CEH\u2013P, and benign and neoplastic mammary lesions were identified. We suggest that, the pathological abnormalities may have been attributed to adverse effects of prolonged administration of MPA.<\/jats:p>","DOI":"10.1016\/j.jfms.2008.10.006","type":"journal-article","created":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T05:24:58Z","timestamp":1228541098000},"page":"518-521","source":"Crossref","is-referenced-by-count":28,"title":["Pathological abnormalities after long-term administration of medroxyprogesterone acetate in a queen"],"prefix":"10.1177","volume":"11","author":[{"given":"Abdulkadir","family":"Keskin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Gorukle 16059, Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnaz","family":"Yilmazbas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Gorukle 16059, Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahsan","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Uludag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa O.","family":"Ozyigit","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Uludag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Gumen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Gorukle 16059, Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"bibr1-j.jfms.2008.10.006","unstructured":"Feldman E.C., Nelson R.W. 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