{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:31:20Z","timestamp":1791952280355,"version":"4.3.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Feline herpesvirus 1 (FHV-1) infection is extremely common in cats and is frequently associated with morbidity because of recurrent ocular and respiratory clinical signs of disease. Enterococcus faecium strain SF68 is an immune-enhancing probiotic used as a dietary supplement. In this pilot study, 12 cats with chronic FHV-1 infection were administered either SF68 or a placebo, monitored for clinical signs of disease, monitored for FHV-1 shedding, and evaluated for FHV-1 specific humoral and cell-mediated immune responses and fecal microbiome stability. Fecal microbial diversity was maintained throughout the study in cats supplemented with SF68, but decreased in cats fed the placebo, indicating a more stable microbiome in cats fed SF68. While clinical results varied among individual cats, the overall findings suggest that administration of the probiotic lessened morbidity associated with chronic FHV-1 infection in some cats. Additional study is warranted to determine efficacy in a clinical setting.<\/jats:p>","DOI":"10.1016\/j.jfms.2008.12.006","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T06:04:52Z","timestamp":1233986692000},"page":"650-654","source":"Crossref","is-referenced-by-count":45,"title":["Pilot Study to Evaluate the Effect of Oral Supplementation of\n                    <i>Enterococcus Faecium<\/i>\n                    SF68 on Cats with Latent Feline Herpesvirus 1"],"prefix":"10.1177","volume":"11","author":[{"given":"Michael R.","family":"Lappin","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Ft Collins, CO 80523, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Veir","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Ft Collins, CO 80523, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer","family":"Satyaraj","sequence":"additional","affiliation":[{"name":"Nestle-Purina PetCare, St Louis, MO, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Czarnecki-Maulden","sequence":"additional","affiliation":[{"name":"Nestle-Purina PetCare, St Louis, MO, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"bibr1-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.04.002"},{"key":"bibr2-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1136\/vr.156.21.669"},{"key":"bibr3-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2003.08.008"},{"key":"bibr4-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(03)90014-4"},{"key":"bibr5-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2000.0084"},{"key":"bibr6-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1993.203.06.0834"},{"key":"bibr7-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.9.1405"},{"key":"bibr8-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.399"},{"key":"bibr9-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.37"},{"key":"bibr10-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2006.08.005"},{"key":"bibr11-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.2.289"},{"key":"bibr12-j.jfms.2008.12.006","first-page":"229","volume":"8","author":"Veir J.K.","year":"2007","journal-title":"Vet Ther"},{"key":"bibr13-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.4.1158"},{"key":"bibr14-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.64.10.3854-3859.1998"},{"key":"bibr15-j.jfms.2008.12.006","first-page":"130","volume-title":"Microbial ecology: fundamentals and applications","author":"Atlas R.","year":"1997","edition":"4"},{"key":"bibr16-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3971-3978.2005"},{"key":"bibr17-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.38"},{"key":"bibr18-j.jfms.2008.12.006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.011"},{"issue":"2","key":"bibr19-j.jfms.2008.12.006","first-page":"37","volume":"29","author":"Czarnecki-Maulden G.L.","year":"2007","journal-title":"Compend Contin Educ Pract Vet"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.jfms.2008.12.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1016\/j.jfms.2008.12.006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.jfms.2008.12.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:13:48Z","timestamp":1777500828000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1016\/j.jfms.2008.12.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1016\/j.jfms.2008.12.006"],"URL":"https:\/\/doi.org\/10.1016\/j.jfms.2008.12.006","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}