{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:10:41Z","timestamp":1790820641751,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Low-grade alimentary lymphoma (LGAL) was diagnosed by histological and immunohistochemical evaluation of full-thickness biopsies from multiple regions of the gastrointestinal tract collected during exploratory laparotomy in 17 cats. The most common clinical signs were weight loss ( n=17) and vomiting and\/or diarrhoea ( n=15). Clinical signs were chronic in 11 cases. Abdominal palpation was abnormal in 12 cats, including diffuse intestinal thickening ( n=8), an abdominal mass due to mesenteric lymph node enlargement ( n=5) and a focal mural intestinal mass ( n=1). The most common ultrasonographic finding was normal or increased intestinal wall thickness with preservation of layering. Ultrasound-guided fine-needle aspirates of mesenteric lymph nodes ( n=9) were incorrectly identified as benign lymphoid hyperplasia in eight cats, in which the histological diagnosis from biopsies was lymphoma. There was neoplastic infiltration of more than one anatomic region of the gastrointestinal tract in 16\/17 cats. The jejunum (15\/15 cats) and ileum (13\/14 cats), followed by the duodenum (10\/12 cats), were the most frequently affected sites. Twelve cats were treated with oral prednisolone and high-dose pulse chlorambucil, two with a modified Madison\u2013Wisconsin multiagent protocol and three with a combination of both protocols. Thirteen of the 17 cats (76%) had complete clinical remission with a median remission time of 18.9 months. Cats that achieved complete remission had significantly longer median survival times (19.3 months) than cats that did not achieve complete remission ( n=4) (4.1\u00a0months; P=0.019). The prognosis for cats with LGAL treated with oral prednisolone in combination with high-dose pulse chlorambucil is good to excellent.<\/jats:p>","DOI":"10.1016\/j.jfms.2009.05.021","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T05:44:09Z","timestamp":1246599849000},"page":"692-700","source":"Crossref","is-referenced-by-count":104,"title":["Low-Grade Alimentary Lymphoma: Clinicopathological Findings and Response to Treatment in 17 Cases"],"prefix":"10.1177","volume":"11","author":[{"given":"Amy E.","family":"Lingard","sequence":"first","affiliation":[{"name":"Valentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Briscoe","sequence":"additional","affiliation":[{"name":"Valentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Beatty","sequence":"additional","affiliation":[{"name":"Valentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony S.","family":"Moore","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Consultants, 379 Lake Innes Drive, Wauchope NSW 2446, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Anapath, PO Box 504, Newport NSW 2106, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Krockenberger","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Services, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Churcher","sequence":"additional","affiliation":[{"name":"North Shore Veterinary Specialist Centre, 64 Atchison Street, Crows Nest NSW 2065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Canfield","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Services, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa R.","family":"Barrs","sequence":"additional","affiliation":[{"name":"Valentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"bibr1-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02703.x"},{"key":"bibr2-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1118"},{"key":"bibr3-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02134.x"},{"issue":"12","key":"bibr4-j.jfms.2009.05.021","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2460\/javma.1995.207.12.1593","volume":"207","author":"Mahony O.M.","year":"1995","journal-title":"J Am Vet Med Assoc"},{"issue":"8","key":"bibr5-j.jfms.2009.05.021","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.2460\/javma.1998.213.08.1144","volume":"213","author":"Zwahlen C.H.","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"bibr6-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb02176.x"},{"key":"bibr7-j.jfms.2009.05.021","first-page":"595","volume-title":"Current veterinary therapy XI","author":"Couto C.G.","year":"1992"},{"key":"bibr8-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(03)00071-9"},{"key":"bibr9-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1999.tb12085.x"},{"issue":"2","key":"bibr10-j.jfms.2009.05.021","first-page":"5","volume":"4","author":"Fondacaro J.V.","year":"1999","journal-title":"Eur J Comp Gastroenterol"},{"key":"bibr11-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2005.05.004"},{"key":"bibr12-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1177\/030098589803500506"},{"key":"bibr13-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-1-15"},{"key":"bibr14-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2001.tb10923.x"},{"key":"bibr15-j.jfms.2009.05.021","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-36-3-224"},{"key":"bibr16-j.jfms.2009.05.021","unstructured":"Mattoon J.S., Auld D.M., Nyland T.G. 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