{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:21:10Z","timestamp":1781288470871,"version":"3.54.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Patient and surgical treatment An 11-year-old, castrated male cat was referred for insulin-resistant diabetes mellitus. It had a ravenous appetite, increased body weight, polyuria\/polydipsia and a dull hair coat. The cat was receiving 25 IU insulin four times daily but blood glucose concentrations remained elevated. Plasma concentrations of growth hormone (GH) (51 \u03bcug\/l, reference range 0.8\u20137.2 \u03bcg\/l) and insulin-like growth factor 1 (IGF-1) (3871 \u03bcg\/l, reference range 39\u2013590 \u03bcg\/l) were highly elevated, whereas those of alpha-melanocyte-stimulating hormone, adrenocorticotropic hormone and Cortisol were normal. Computed tomography revealed a thick palatum molle and an enlarged pituitary gland, indicating a pituitary neoplasm. Microsurgical transsphenoidal hypophysectomy was performed and microscopic examination of the surgical specimen revealed an acidophilic, infiltrative pituitary adenoma that showed positive immunostaining for GH.<\/jats:p>\n                  <jats:p>Outcome The clinical signs resolved and 3 weeks after surgery the cat no longer required insulin administration. One year after hypophysectomy the plasma concentrations of GH and IGF-1 were 2.4 \u03bcg\/l and 113 \u03bcg\/l, respectively.<\/jats:p>\n                  <jats:p>Practical relevance This is the first report detailing transsphenoidal hypophysectomy as a feasible and effective treatment for feline acromegaly due to a pituitary somatotroph adenoma. Moreover, in this patient, concurrent insulin-resistant diabetes mellitus resolved completely. The surgery is discussed in the context of human and other feline therapies for acromegaly.<\/jats:p>","DOI":"10.1016\/j.jfms.2010.03.014","type":"journal-article","created":{"date-parts":[[2010,4,25]],"date-time":"2010-04-25T04:13:23Z","timestamp":1272168803000},"page":"406-410","source":"Crossref","is-referenced-by-count":40,"title":["Successful Treatment of Acromegaly in a Diabetic Cat with Transsphenoidal Hypophysectomy"],"prefix":"10.1177","volume":"12","author":[{"given":"Bj\u00f6rn P","family":"Meij","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Auriemma","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Imaging, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Grinwis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny J C W M","family":"Buijtels","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans S","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"bibr1-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1990.tb00897.x"},{"key":"bibr2-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03041.x"},{"key":"bibr3-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2008.07.004"},{"key":"bibr4-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2000.0097"},{"key":"bibr5-j.jfms.2010.03.014","first-page":"625","volume":"18","author":"Javadi S","year":"2004","journal-title":"J Vet Intern Med"},{"key":"bibr6-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2001.17843"},{"key":"bibr7-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00283-6"},{"key":"bibr8-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2008.03.001"},{"key":"bibr9-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2004.tb00154.x"},{"key":"bibr10-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03040.x"},{"key":"bibr11-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00282-4"},{"key":"bibr12-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-1-92"},{"key":"bibr13-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2003.09.004"},{"key":"bibr14-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02525.x"},{"key":"bibr15-j.jfms.2010.03.014","first-page":"682","volume":"34","author":"Abrams-Ogg ACG","year":"1993","journal-title":"Can Vet J"},{"key":"bibr16-j.jfms.2010.03.014","first-page":"53","volume":"43","author":"Abrams-Ogg ACG","year":"2002","journal-title":"Can Vet J"},{"key":"bibr17-j.jfms.2010.03.014","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1748-5827.2008.00590.x","volume":"49","author":"Blois SL","year":"2008","journal-title":"J Small Anim Pract"},{"key":"bibr18-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1998.213.03.374"},{"key":"bibr19-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00078.x"},{"key":"bibr20-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2002.tb00078.x"},{"key":"bibr21-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb00714.x"},{"key":"bibr22-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2002.tb12469.x"},{"key":"bibr23-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0424"},{"key":"bibr24-j.jfms.2010.03.014","first-page":"13","volume-title":"Clinical endocrinology of dogs and cats","author":"Meij BP","year":"2010","edition":"2"},{"key":"bibr25-j.jfms.2010.03.014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03469.x"}],"container-title":["Journal of Feline Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.jfms.2010.03.014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1016\/j.jfms.2010.03.014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.jfms.2010.03.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:14:18Z","timestamp":1777500858000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1016\/j.jfms.2010.03.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1016\/j.jfms.2010.03.014"],"URL":"https:\/\/doi.org\/10.1016\/j.jfms.2010.03.014","relation":{},"ISSN":["1098-612X","1532-2750"],"issn-type":[{"value":"1098-612X","type":"print"},{"value":"1532-2750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}