{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:23:35Z","timestamp":1784071415404,"version":"3.55.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>Case presentation and assessment A 3-month-old female Cornish Rex kitten was found to have non-painful swelling of the carpal and tarsal regions when presented for routine neutering. The kitten was smaller in stature and less active than its siblings and, according to the owner, had a bunny-hopping gait, was reluctant to climb stairs and strained during defecation. Radiography of the affected limbs and a subsequent radiographic survey of the entire skeleton demonstrated features consistent with rickets. The three littermates were clinically and radiographically normal. As a nutritionally complete diet was being fed, it seemed most likely that the kitten had an inborn error related to vitamin D metabolism. Serum biochemistry demonstrated reduced total alkaline phosphatase activity and increased concentrations of parathyroid hormone. Concentrations of 1,25- and 25-hydroxycholecalciferol were markedly reduced, confirming the diagnosis of rickets.<\/jats:p>\n                  <jats:p>Treatment The kitten was treated with calcitriol, administered orally once daily, and improved rapidly both clinically and radiologically. Serial laboratory studies suggested that the error in vitamin D metabolism was transient, and, at the time of writing, as an adult, the cat appears to require no ongoing replacement calcitriol therapy.<\/jats:p>\n                  <jats:p>Clinical relevance This case emphasises the value of examining a full \u2018calcium profile\u2019 via a human or veterinary reference laboratory, and a favourable prognosis in some kittens with rickets makes such investigations worthwhile. Even when finances preclude detailed investigation, trial therapy using a nutritionally complete diet and physiological doses of calcitriol or cholecalciferol is inexpensive and can produce a good response.<\/jats:p>","DOI":"10.1016\/j.jfms.2011.05.010","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T12:31:22Z","timestamp":1309177882000},"page":"526-531","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Vitamin D-Dependent Non-Type 1, Non-Type 2 Rickets in a 3-Month-Old Cornish Rex Kitten"],"prefix":"10.1177","volume":"13","author":[{"given":"Angela M","family":"Phillips","sequence":"first","affiliation":[{"name":"Sydney Animal Hospitals Inner West, 1A Northumberland Avenue, Stanmore, NSW 2048, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C","family":"Fawcett","sequence":"additional","affiliation":[{"name":"Sydney Animal Hospitals Inner West, 1A Northumberland Avenue, Stanmore, NSW 2048, Australia"},{"name":"Faculty of Veterinary Science, University of Sydney, B14, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme S","family":"Allan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, University of Sydney, B14, NSW 2006, Australia"},{"name":"Veterinary Imaging Associates, PO Box 300, St Leonards, NSW 1590, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Pacific Laboratory Medicine Services, The Endocrine Unit, Block 1a, Royal North Shore Hospital, St Leonards, NSW 2065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Fraser","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, University of Sydney, B14, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malik","sequence":"additional","affiliation":[{"name":"Centre for Veterinary Education, The University of Sydney, B22, NSW 2006, 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