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Data came from survey responses (45 cats) or Federal Drug Administration reports (16 cats). Cat age (7 weeks\u201419 years), breed, and gender ranged widely. Most were healthy (87%) prior to anaphylaxis. Ophthalmic antibiotics commonly were administered for conjunctival (65%) or corneal (11%) disease, or ocular lubrication (7%) and contained bacitracin, neomycin, and polymyxin B (44%), or oxytetracycline and polymyxin B (21%). Polymyxin B was present in all cases. Vaccines or other drugs were also administered to 51% of cats. In 56% cases, anaphylaxis occurred within 10 min of drug application. Most (82%) cats survived. Although a causal association was not proved, ophthalmic antibiotic administration preceded anaphylaxis in all cats. Like other drugs, ophthalmic antibiotics should be used only when indicated.<\/jats:p>","DOI":"10.1016\/j.jfms.2011.06.007","type":"journal-article","created":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T17:03:28Z","timestamp":1315674208000},"page":"744-751","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Anaphylactic Events Observed within 4 h of Ocular Application of an Antibiotic-Containing Ophthalmic Preparation: 61 Cats (1993\u20132010)"],"prefix":"10.1177","volume":"13","author":[{"given":"Karen M","family":"Hume-Smith","sequence":"first","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson D","family":"Groth","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, 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