{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:58:01Z","timestamp":1788875881983,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Feline Medicine and Surgery"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>Medical records (2005\u20132009) of a feline-only practice were searched for cats with degenerative joint disease (DJD) treated using meloxicam. DJD was diagnosed by the presence of at least two of the following: (i) altered mobility (observed by the owner), (ii) abnormal physical findings, (iii) characteristic radiographic changes. The primary study cohort consisted of cats older than 7 years that had received meloxicam for variable intervals in excess of 6 months, and for which complete records were available. These cats were subdivided according to whether detectable chronic kidney disease (CKD) was present (\u2018renal group\u2019), or not (\u2018non-renal group\u2019), and, for the \u2018renal group\u2019, according to the cat's IRIS category. Serum biochemistry, urinalysis (including urine specific gravity [USG]), body mass and condition score were monitored regularly. Progression of CKD in the \u2018renal group\u2019 and \u2018non-renal group\u2019 of cats was compared to two groups of age- and IRIS-matched control cats not receiving meloxicam (from the same clinic, over the same time period). The study was thus a case\u2014control design, with two study groups. Thirty-eight cats with DJD receiving long-term meloxicam therapy met the inclusion criteria. Of these, 22 cats had stable CKD at the start of treatment (stage 1, eight cats; stage 2, 13 cats; stage 3, one cat). No cats initially had an elevated urinary protein to creatinine ratio. The remaining 16 cats initially had normal renal analytes and adequately concentrated urine. The median age of the \u2018renal\u2019 and \u2018non-renal\u2019 meloxicam groups was 15.5 and 13.4 years, respectively. The median treatment duration was 467 days in the \u2018renal group\u2019 and 327 days in the \u2018non-renal group\u2019. After titration (to the lowest effective dose), the median maintenance dose was 0.02 mg\/kg\/day in both groups (range 0.015\u20130.033 mg\/kg\/day). There was no difference in sequential serum creatinine concentration or USG measurements between the \u2018non-renal group\u2019 treated with meloxicam compared to control cats not treated with meloxicam. There was less progression of renal disease in the \u2018renal group\u2019 treated with meloxicam compared to the age- and IRIS-matched cats with CKD not given meloxicam. These results suggest that a long-term maintenance dose of 0.02 mg\/kg of meloxicam can be safely administered to cats older than 7 years even if they have CKD, provided their overall clinical status is stable. Long-term meloxicam therapy may slow the progression of renal disease in some cats suffering from both CKD and DJD. Prospective studies are required to confirm these findings.<\/jats:p>","DOI":"10.1016\/j.jfms.2011.06.008","type":"journal-article","created":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T17:03:44Z","timestamp":1315674224000},"page":"752-761","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":100,"title":["Retrospective Case\u2014Control Study of the Effects of Long-Term Dosing with Meloxicam on Renal Function in Aged Cats with Degenerative Joint Disease"],"prefix":"10.1177","volume":"13","author":[{"given":"Richard A","family":"Gowan","sequence":"first","affiliation":[{"name":"The Cat Clinic, 1 Miller Street, Prahran, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E","family":"Lingard","sequence":"additional","affiliation":[{"name":"The Cat Clinic, 1 Miller Street, Prahran, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Johnston","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim, Binger Strasse, Ingelheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wibke","family":"Stansen","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim, Binger Strasse, Ingelheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malik","sequence":"additional","affiliation":[{"name":"Centre for Veterinary Education, Level 2, Conference Centre, B22, The University of Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"bibr1-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00597.x"},{"key":"bibr2-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.628"},{"key":"bibr3-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.25.793"},{"key":"bibr4-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2005.tb00340.x"},{"key":"bibr5-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.01.003"},{"key":"bibr6-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1968.tb04605.x"},{"key":"bibr7-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.10.007"},{"key":"bibr8-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2009.09.016"},{"key":"bibr9-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.01.002"},{"key":"bibr10-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2010.05.004"},{"key":"bibr11-j.jfms.2011.06.008","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2460\/javma.1987.190.09.1196","volume":"190","author":"Dibartola SP","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"bibr12-j.jfms.2011.06.008","first-page":"127","volume":"14","author":"Lulich JP","year":"1992","journal-title":"Compend Contin Educ Pract Vet"},{"key":"bibr13-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03598.x"},{"key":"bibr14-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2004.00614.x"},{"key":"bibr15-j.jfms.2011.06.008","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.6.949"},{"key":"bibr16-j.jfms.2011.06.008","unstructured":"International Renal Interest Society Staging of CKD 2006; 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