{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:04:12Z","timestamp":1759334652451,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.jfo.2011.08.016","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T09:01:57Z","timestamp":1334048517000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacit\u00e9 et tol\u00e9rance d\u2019une nouvelle formulation oculaire de l\u00e9vocabastine sans conservateur (Levofree\u00ae) \u00e9valu\u00e9es lors d\u2019un test de provocation conjonctivale"],"prefix":"10.1016","volume":"35","author":[{"given":"C.","family":"Allaire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Siou-Mermet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bassols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfo.2011.08.016_bib0005","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/bmj.315.7111.816","article-title":"Managing eye conditions in general practice","volume":"315","author":"Manners","year":"1997","journal-title":"Brit Med J"},{"key":"10.1016\/j.jfo.2011.08.016_bib0010","first-page":"1","article-title":"Epidemiology of hay fever and perennial allergic rhinitis","volume":"21","author":"Weeke","year":"1987","journal-title":"Monogr Allergy"},{"key":"10.1016\/j.jfo.2011.08.016_bib0015","first-page":"95","article-title":"Differential diagnosis of ocular allergic disorders","volume":"70","author":"Abelson","year":"1993","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jfo.2011.08.016_bib0020","first-page":"1","article-title":"Conjonctivites allergiques saisonni\u00e8res et perannuelles","volume":"141","author":"Mortemousque","year":"2007","journal-title":"Real Ophtalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0025","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2165\/00003495-199243020-00003","article-title":"Drug treatment of allergic conjunctivitis. A review of the evidence","volume":"43","author":"Ciprandi","year":"1992","journal-title":"Drugs"},{"key":"10.1016\/j.jfo.2011.08.016_bib0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-0420.1999.tb01172.x","article-title":"Comparison of the conjunctival allergen challenge model with the environmental model of allergic conjunctivitis","volume":"228","author":"Abelson","year":"1999","journal-title":"Acta Ophthalmol Scand Suppl"},{"key":"10.1016\/j.jfo.2011.08.016_bib0035","first-page":"23","article-title":"Conjonctivites allergiques\u00a0: principes th\u00e9rapeutiques","volume":"36","author":"Hannouche","year":"1996","journal-title":"Real Ophtalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/00055735-199808000-00010","article-title":"The current and future therapy of allergic conjunctivitis","volume":"9","author":"Friedlaender","year":"1998","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0045","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1398-9995.1990.tb00531.x","article-title":"Absence of central effects with levocabastine eye drops","volume":"45","author":"Arriaga","year":"1990","journal-title":"Allergy"},{"key":"10.1016\/j.jfo.2011.08.016_bib0050","first-page":"75","article-title":"Effects of topical administration of levocabastine on psychomotor and cognitive function","volume":"67","author":"Rombaut","year":"1991","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jfo.2011.08.016_bib0055","first-page":"S26","article-title":"A review of the tolerability and safety of levocabastine eye drops and nasal spray. Implications for patient management","volume":"4","author":"Howarth","year":"1995","journal-title":"Mediators Inflamn"},{"key":"10.1016\/j.jfo.2011.08.016_bib0060","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2165\/00003495-199550060-00009","article-title":"Levocabastine: an update of its pharmacology, clinical efficacy and tolerability in the topical treatment of allergic rhinitis and conjunctivitis","volume":"50","author":"Noble","year":"1995","journal-title":"Drugs"},{"key":"10.1016\/j.jfo.2011.08.016_bib0065","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1365-2222.1993.tb00368.x","article-title":"Rapid onset of action of levocabastine eye drops in histamineinduced conjunctivitis","volume":"23","author":"Stokes","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jfo.2011.08.016_bib0070","first-page":"S16","article-title":"Levocabastine eye drops are effective and well tolerated for the treatment of allergic conjunctivitis in children","volume":"4","author":"W\u00fcthrich","year":"1995","journal-title":"Mediators Inflamn"},{"key":"10.1016\/j.jfo.2011.08.016_bib0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0039-6257(80)90072-7","article-title":"Corneal cytotoxicity of topically applied drugs, excipients and preservatives","volume":"25","author":"Burstein","year":"1980","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0080","first-page":"376","article-title":"\u00c9tude exp\u00e9rimentale sur les effets cytotoxiques des conservateurs pour la surface corn\u00e9oconjonctivale","volume":"10","author":"Baudouin","year":"1996","journal-title":"Ophtalmologie"},{"key":"10.1016\/j.jfo.2011.08.016_bib0085","first-page":"619","article-title":"Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells","volume":"40","author":"De Saint Jean","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2011.08.016_bib0090","first-page":"186","article-title":"Tol\u00e9rance clinique des collyres antiglaucomateux conserv\u00e9s et non conserv\u00e9s. R\u00e9sultats d\u2019une enqu\u00eate in\u00e9dite en Europe","volume":"22","author":"Levrat","year":"1999","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0095","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2515\/therapie:2004050","article-title":"A comparative study of the ocular tolerance after administration of antiallergic eye drops with or without a preservative","volume":"59","author":"Beden","year":"2004","journal-title":"Therapie"},{"key":"10.1016\/j.jfo.2011.08.016_bib0100","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0181-5512(07)89597-0","article-title":"Formes fronti\u00e8res de l\u2019allergie","volume":"30","author":"Baudouin","year":"2007","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0105","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1755-3768.2008.01250.x","article-title":"Detrimental effect of preservatives in eye drops: implications for the treatment of glaucoma","volume":"86","author":"Baudouin","year":"2008","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0110","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.preteyeres.2010.03.001","article-title":"Preservatives in eye drops: the good, the bad and the ugly","volume":"29","author":"Baudouin","year":"2010","journal-title":"Prog Retinal Eye Res"},{"key":"10.1016\/j.jfo.2011.08.016_bib0115","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jfo.2010.06.018","article-title":"Les conservateurs des collyres\u00a0: vers une prise de conscience de leur toxicit\u00e9","volume":"33","author":"Vaede","year":"2010","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0120","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/bjo.59.11.667","article-title":"Effect of benzalkonium chloride on the stability of the precorneal tear film in rabbit and man","volume":"59","author":"Wilson","year":"1975","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0125","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/bjo.79.4.339","article-title":"Effect of timolol with and without preservative on the basal tear turnover in glaucoma","volume":"79","author":"Kuppens","year":"1995","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/bjo.82.1.39","article-title":"Short-term comparative study of topical 2\u00a0% carteolol with and without benzalkonium chloride in healthy volunteers","volume":"82","author":"Baudouin","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0135","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0181-5512(07)89596-9","article-title":"Les tests de provocation conjonctivaux","volume":"30","author":"Mortemousque","year":"2007","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0140","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/archopht.1990.01070030090035","article-title":"Conjunctival allergen challenge","volume":"108","author":"Abelson","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0145","first-page":"32","article-title":"A tool for tuning antiallergy drugs","author":"Abelson","year":"1998","journal-title":"Rev Ophthalmol"},{"unstructured":"CPMP ICH E9. Statistical principles for clinical trials (CPMP\/ICH\/363\/96), September 1998. Accessible \u00e0\u00a0: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500002928.pdf. Lien v\u00e9rifi\u00e9 le 18\u00a0juillet 2011.","key":"10.1016\/j.jfo.2011.08.016_bib0150"},{"key":"10.1016\/j.jfo.2011.08.016_bib0155","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0181-5512(05)81050-2","article-title":"Comparaison de trois collyres antiallergiques lors du test de provocation conjonctivale sp\u00e9cifique\u00a0: m\u00e9quitazine, l\u00e9vocabastine et dexam\u00e9thasone","volume":"28","author":"Richard","year":"2005","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0160","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/bjo.86.4.418","article-title":"Prevalence of ocular symptoms and signs with preserved and preservative-free glaucoma medication","volume":"86","author":"Pisella","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jfo.2011.08.016_bib0165","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/112067210701700311","article-title":"Ocular symptoms and signs with preserved and preservative-free glaucoma medications","volume":"17","author":"Jaenen","year":"2007","journal-title":"Eur J Ophthalmol"}],"container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551212000757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551212000757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:02:40Z","timestamp":1759258960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0181551212000757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0181551212000757"],"URL":"https:\/\/doi.org\/10.1016\/j.jfo.2011.08.016","relation":{},"ISSN":["0181-5512"],"issn-type":[{"type":"print","value":"0181-5512"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacit\u00e9 et tol\u00e9rance d\u2019une nouvelle formulation oculaire de l\u00e9vocabastine sans conservateur (Levofree\u00ae) \u00e9valu\u00e9es lors d\u2019un test de provocation conjonctivale","name":"articletitle","label":"Article Title"},{"value":"Journal Fran\u00e7ais d'Ophtalmologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfo.2011.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}