{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:37:35Z","timestamp":1790192255458,"version":"4.1.0"},"reference-count":140,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"HORUS PHARMA"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jfo.2016.07.006","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:21:03Z","timestamp":1473452463000},"page":"641-651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperosmolarit\u00e9\u00a0: effets intracellulaires et implication dans la s\u00e9cheresse oculaire"],"prefix":"10.1016","volume":"39","author":[{"given":"E.","family":"Warcoin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Clouzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Brignole-Baudouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Baudouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfo.2016.07.006_bib0705","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)","volume":"5","author":"DEWS","year":"2007","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jfo.2016.07.006_bib0710","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ajo.2006.11.060","article-title":"Impact of dry eye syndrome on vision-related quality of life","volume":"143","author":"Miljanovi\u0107","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0715","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0181-5512(07)89584-2","article-title":"A new approach for better comprehension of diseases of the ocular surface","volume":"30","author":"Baudouin","year":"2007","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0720","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1167\/iovs.10-5390","article-title":"An objective approach to dry eye disease severity","volume":"51","author":"Sullivan","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib0725","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ajo.2010.10.032","article-title":"Tear osmolarity in the diagnosis and management of dry eye disease","volume":"151","author":"Lemp","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0730","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1167\/iovs.05-1504","article-title":"Tear film osmolarity: determination of a referent for dry eye diagnosis","volume":"47","author":"Tomlinson","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib0735","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/02713683.2010.484557","article-title":"Performance of tear osmolarity compared to previous diagnostic tests for dry eye diseases","volume":"35","author":"Versura","year":"2010","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib0740","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","article-title":"Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN Group Meeting","volume":"11","author":"Baudouin","year":"2013","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jfo.2016.07.006_bib0745","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/978-1-4615-2417-5_83","article-title":"Tear osmolarity--a new gold standard?","volume":"350","author":"Farris","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0750","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/archopht.1978.03910050373015","article-title":"Osmolarity of tear microvolumes in keratoconjunctivitis sicca","volume":"96","author":"Gilbard","year":"1978","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0755","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.ajo.2014.03.002","article-title":"New testing options for diagnosing and grading dry eye disease","volume":"157","author":"Foulks","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0760","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.survophthal.2011.11.003","article-title":"Evaluation of dry eye","volume":"57","author":"McGinnigle","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0765","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1097\/ICO.0b013e318242fd60","article-title":"Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management","volume":"31","author":"Sullivan","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2016.07.006_bib0770","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/jamaophthalmol.2015.0429","article-title":"Variability of tear osmolarity in patients with dry eye","volume":"133","author":"Bunya","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0775","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3109\/02713683.2013.763987","article-title":"Impact of time between collection and collection method on human tear fluid osmolarity","volume":"38","author":"Keech","year":"2013","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib0780","first-page":"252","article-title":"The effects of hyperosmotic stress on rabbit ocular surface and mucin 5AC expression","volume":"47","author":"Cai","year":"2011","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"10.1016\/j.jfo.2016.07.006_bib0785","first-page":"330","article-title":"A primary study of L-carnitine protective effect on corneal and conjunctival epithelium of mouse dry eye model induced by hyperosmolar saline","volume":"48","author":"Huo","year":"2012","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"10.1016\/j.jfo.2016.07.006_bib0790","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/108076803321908400","article-title":"A convenient rabbit model of ocular epithelium damage induced by osmotic dehydration","volume":"19","author":"Katsuyama","year":"2003","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.jfo.2016.07.006_bib0795","doi-asserted-by":"crossref","first-page":"18243","DOI":"10.1074\/jbc.M000522200","article-title":"Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation","volume":"275","author":"Dmitrieva","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib0800","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1073\/pnas.98.4.1999","article-title":"Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells","volume":"98","author":"K\u00fcltz","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib0805","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.1074\/jbc.R700042200","article-title":"Intracellular organic osmolytes: function and regulation","volume":"283","author":"Burg","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib0810","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/physrev.00056.2006","article-title":"Cellular response to hyperosmotic stresses","volume":"87","author":"Burg","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jfo.2016.07.006_bib0815","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/physrev.1998.78.1.247","article-title":"Functional significance of cell volume regulatory mechanisms","volume":"78","author":"Lang","year":"1998","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jfo.2016.07.006_bib0820","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1095-6433(01)00439-1","article-title":"Cell cycle delay and apoptosis in response to osmotic stress","volume":"130","author":"Dmitrieva","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0825","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mrfmmm.2004.06.053","article-title":"Hypertonic stress response","volume":"569","author":"Dmitrieva","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib0830","doi-asserted-by":"crossref","first-page":"e662","DOI":"10.1038\/cddis.2013.189","article-title":"Hyperosmotic stress induces cell cycle arrest in retinal pigmented epithelial cells","volume":"4","author":"Arsenijevic","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jfo.2016.07.006_bib0835","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.7112124","article-title":"Living with water stress: evolution of osmolyte systems","volume":"217","author":"Yancey","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.jfo.2016.07.006_bib0840","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10254-003-0009-x","article-title":"Cell volume regulation: osmolytes, osmolyte transport, and signal transduction","volume":"148","author":"Wehner","year":"2003","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0845","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1016\/j.bbadis.2014.07.030","article-title":"High glucose-induced hyperosmolarity impacts proliferation, cytoskeleton remodeling and migration of human induced pluripotent stem cells via aquaporin-1","volume":"1842","author":"Madonna","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jfo.2016.07.006_bib0850","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1095-6433(01)00429-9","article-title":"The cytoskeleton and cell volume regulation","volume":"130","author":"Pedersen","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0855","doi-asserted-by":"crossref","first-page":"C850","DOI":"10.1152\/ajpcell.00018.2002","article-title":"Osmotic stress-induced remodeling of the cortical cytoskeleton","volume":"283","author":"Di Ciano","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0860","doi-asserted-by":"crossref","first-page":"F336","DOI":"10.1152\/ajprenal.00003.2003","article-title":"Regulatory volume increase is associated with p38 kinase-dependent actin cytoskeleton remodeling in rat kidney MTAL","volume":"285","author":"Bustamante","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0865","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1074\/jbc.M509386200","article-title":"The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin","volume":"281","author":"Mazzochi","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib0870","doi-asserted-by":"crossref","first-page":"C902","DOI":"10.1152\/ajpcell.1997.273.3.C902","article-title":"Hypertonic induction of the cell adhesion molecule beta 1-integrin in MDCK cells","volume":"273","author":"Sheikh-Hamad","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0875","doi-asserted-by":"crossref","first-page":"F223","DOI":"10.1152\/ajprenal.00371.2004","article-title":"Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration","volume":"290","author":"Moeckel","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0880","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1073\/pnas.0308463100","article-title":"Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo","volume":"101","author":"Dmitrieva","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib0885","doi-asserted-by":"crossref","first-page":"e12108","DOI":"10.1371\/journal.pone.0012108","article-title":"Mediator of DNA Damage Checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP\/OREBP","volume":"5","author":"Kunin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jfo.2016.07.006_bib0890","doi-asserted-by":"crossref","first-page":"13645","DOI":"10.1074\/jbc.273.22.13645","article-title":"Hyperosmolality causes growth arrest of murine kidney cells. Induction of GADD45 and GADD153 by osmosensing via stress-activated protein kinase 2","volume":"273","author":"K\u00fcltz","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib0895","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/35044005","article-title":"The DNA damage response: putting checkpoints in perspective","volume":"408","author":"Zhou","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jfo.2016.07.006_bib0900","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000096315","article-title":"Cell volume-regulated cation channels","volume":"152","author":"Wehner","year":"2006","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0905","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00232-001-0023-3","article-title":"Osmotic stimulation of the Na+\/H+ exchanger NHE1: relationship to the activation of three MAPK pathways","volume":"181","author":"Gillis","year":"2001","journal-title":"J Membr Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0910","doi-asserted-by":"crossref","first-page":"23823","DOI":"10.1016\/S0021-9258(18)35911-8","article-title":"Activation of the Na+\/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism","volume":"267","author":"Grinstein","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib0915","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s002320001098","article-title":"Adaptation by corneal epithelial cells to chronic hypertonic stress depends on upregulation of Na:K:2Cl cotransporter gene and protein expression and ion transport activity","volume":"177","author":"Bildin","year":"2000","journal-title":"J Membr Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0920","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.exer.2006.10.011","article-title":"Fate of hypertonicity-stressed corneal epithelial cells depends on differential MAPK activation and p38MAPK\/Na-K-2Cl cotransporter1 interaction","volume":"84","author":"Cap\u00f3-Aponte","year":"2007","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib0925","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s002329900503","article-title":"Osmotic shrinkage activates nonselective cation (NSC) channels in various cell types","volume":"168","author":"Koch","year":"1999","journal-title":"J Membr Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0930","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-5793(01)02303-1","article-title":"The epithelial Na(+) channel (ENaC) is related to the hypertonicity-induced Na(+) conductance in rat hepatocytes","volume":"494","author":"B\u00f6hmer","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jfo.2016.07.006_bib0935","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00424-007-0355-7","article-title":"Subunits alpha, beta and gamma of the epithelial Na+ channel (ENaC) are functionally related to the hypertonicity-induced cation channel (HICC) in rat hepatocytes","volume":"455","author":"Plettenberg","year":"2008","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jfo.2016.07.006_bib0940","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1167\/iovs.10-5801","article-title":"TRPV1 activation is required for hypertonicity-stimulated inflammatory cytokine release in human corneal epithelial cells","volume":"52","author":"Pan","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib0945","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1681\/ASN.2005121381","article-title":"Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro rats","volume":"17","author":"Li","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0950","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1517\/14728222.11.3.307","article-title":"Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain","volume":"11","author":"Ma","year":"2007","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jfo.2016.07.006_bib0955","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-002-2002-8","article-title":"Hypertonicity-induced p38MAPK activation elicits recovery of corneal epithelial cell volume and layer integrity","volume":"193","author":"Bildin","year":"2003","journal-title":"J Membr Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0960","first-page":"799","article-title":"Okadaic acid inhibition of KCl cotransport","volume":"97","author":"Jennings","year":"1991","journal-title":"Evidence that protein dephosphorylation is necessary for activation of transport by either cell swelling or N-ethylmaleimide. J Gen Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0965","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.exer.2007.02.007","article-title":"Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells","volume":"84","author":"Cap\u00f3-Aponte","year":"2007","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib0970","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1472-8206.2003.00197.x","article-title":"Structure and pharmacology of swelling-sensitive chloride channels, I(Cl,swell)","volume":"17","author":"d\u2019Anglemont de Tassigny","year":"2003","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0975","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1085\/jgp.118.3.251","article-title":"Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release","volume":"118","author":"Sabirov","year":"2001","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib0980","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000113743","article-title":"Swelling-induced taurine transport: relationship with chloride channels, anion-exchangers and other swelling-activated transport pathways","volume":"21","author":"Shennan","year":"2008","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jfo.2016.07.006_bib0985","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1167\/iovs.11-8581","article-title":"Four subunits (\u03b1\u03b2\u03b3\u03b4) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations","volume":"53","author":"Krueger","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib0990","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/exer.1999.0675","article-title":"Immunochemical analysis of the sodium channel in rodent and human eye","volume":"69","author":"Mirshahi","year":"1999","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib0995","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000055635","article-title":"Mineralocorticoid hormone signaling regulates the \u201cepithelial sodium channel\u201d in fibroblasts from human cornea","volume":"33","author":"Mirshahi","year":"2001","journal-title":"Ophthalmic Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1000","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00418-012-0924-5","article-title":"Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells","volume":"137","author":"Mergler","year":"2012","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1005","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jcp.21141","article-title":"Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling","volume":"213","author":"Zhang","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1010","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/978-1-4615-5359-5_90","article-title":"Effects of chronic hypertonic stress on regulatory volume increase and Na-K-2Cl cotransporter expression in cultured corneal epithelial cells","volume":"438","author":"Bildin","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1015","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.preteyeres.2008.04.001","article-title":"Functions of aquaporins in the eye","volume":"27","author":"Verkman","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1020","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.bbagen.2013.09.033","article-title":"Human aquaporins: regulators of transcellular water flow","volume":"1840","author":"Day","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jfo.2016.07.006_bib1025","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1073\/pnas.91.14.6269","article-title":"Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells","volume":"91","author":"Ishibashi","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib1030","doi-asserted-by":"crossref","first-page":"15765","DOI":"10.1074\/jbc.M209980200","article-title":"Hypertonicity-induced Aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene","volume":"278","author":"Umenishi","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib1035","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1074\/jbc.275.12.9070","article-title":"Hypertonic induction of aquaporin-5 expression through an ERK-dependent pathway","volume":"275","author":"Hoffert","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib1040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.proghi.2004.03.001","article-title":"Aquaporins: water channel proteins of the cell membrane","volume":"39","author":"Takata","year":"2004","journal-title":"Prog Histochem Cytochem"},{"key":"10.1016\/j.jfo.2016.07.006_bib1045","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/BF02896188","article-title":"Effect of cyclosporin A eye drop on keratoconjunctivitis sicca and its mechanism","volume":"25","author":"Sun","year":"2005","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1006\/exer.1999.0814","article-title":"Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5","volume":"70","author":"Moore","year":"2000","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-2187-8-5","article-title":"NFAT5 in cellular adaptation to hypertonic stress\u2013regulations and functional significance","volume":"8","author":"Cheung","year":"2013","journal-title":"J Mol Signal"},{"key":"10.1016\/j.jfo.2016.07.006_bib1060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1073\/pnas.241637298","article-title":"Activity of the TonEBP\/OREBP transactivation domain varies directly with extracellular NaCl concentration","volume":"99","author":"Ferraris","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib1065","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1073\/pnas.96.5.2538","article-title":"Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity","volume":"96","author":"Miyakawa","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib1070","first-page":"360","article-title":"Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5","volume":"21","author":"Hollborn","year":"2015","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2016.07.006_bib1075","doi-asserted-by":"crossref","first-page":"F506","DOI":"10.1152\/ajprenal.00417.2004","article-title":"Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP\/OREBP","volume":"289","author":"Zhang","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1080","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.1073\/pnas.0403062101","article-title":"ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP\/OREBP","volume":"101","author":"Irarrazabal","year":"2004","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1085","doi-asserted-by":"crossref","first-page":"16800","DOI":"10.1073\/pnas.222659799","article-title":"cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer\/osmotic response element-binding protein","volume":"99","author":"Ferraris","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib1090","doi-asserted-by":"crossref","first-page":"46085","DOI":"10.1074\/jbc.M208138200","article-title":"Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein\/tonicity-responsive enhancer-binding protein (OREBP\/TonEBP)","volume":"277","author":"Ko","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib1095","doi-asserted-by":"crossref","first-page":"F140","DOI":"10.1152\/ajprenal.00471.2014","article-title":"PKC-\u03b1 contributes to high NaCl-induced activation of NFAT5 (TonEBP\/OREBP) through MAPK ERK1\/2","volume":"308","author":"Wang","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1100","doi-asserted-by":"crossref","first-page":"F1169","DOI":"10.1152\/ajprenal.00378.2005","article-title":"Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP\/OREBP","volume":"290","author":"Zhou","year":"2006","journal-title":"AJP Ren Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1105","doi-asserted-by":"crossref","first-page":"10742","DOI":"10.1073\/pnas.91.22.10742","article-title":"Cloning, genomic organization, and osmotic response of the aldose reductase gene","volume":"91","author":"Ferraris","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib1110","doi-asserted-by":"crossref","first-page":"C667","DOI":"10.1152\/ajpcell.1999.276.3.C667","article-title":"Functional consensus for mammalian osmotic response elements","volume":"276","author":"Ferraris","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1115","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.physiol.59.1.437","article-title":"Regulation of gene expression by hypertonicity","volume":"59","author":"Burg","year":"1997","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1120","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/physrev.1991.71.4.1081","article-title":"Renal medullary organic osmolytes","volume":"71","author":"Garcia-Perez","year":"1991","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jfo.2016.07.006_bib1125","first-page":"2916","article-title":"Osmosensitive taurine transporter expression and activity in human corneal epithelial cells","volume":"43","author":"Shioda","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1130","first-page":"2512","article-title":"Hypertonic stress increases NaK ATPase, taurine, and myoinositol in human lens and retinal pigment epithelial cultures","volume":"34","author":"Yokoyama","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1135","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1167\/iovs.03-0503","article-title":"Osmoregulation of taurine transporter function and expression in retinal pigment epithelial, ganglion, and muller cells","volume":"45","author":"El-Sherbeny","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0005-2736(99)00058-9","article-title":"Hypertonicity stimulates taurine uptake and transporter gene expression in Caco-2 cells","volume":"1419","author":"Satsu","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jfo.2016.07.006_bib1145","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00424-002-0849-2","article-title":"TonEBP transcriptional activator in the cellular response to increased osmolality","volume":"444","author":"Woo","year":"2002","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jfo.2016.07.006_bib1150","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0955-0674(95)80002-6","article-title":"Cell volume regulated transporters of compatible osmolytes","volume":"7","author":"Kwon","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1155","first-page":"F753","article-title":"Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity","volume":"274","author":"Miyakawa","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1160","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/BJ20031838","article-title":"Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)\/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells","volume":"382","author":"Ito","year":"2004","journal-title":"Biochem J"},{"key":"10.1016\/j.jfo.2016.07.006_bib1165","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1128\/MCB.22.16.5753-5760.2002","article-title":"TonEBP\/NFAT5 stimulates transcription of HSP70 in response to hypertonicity","volume":"22","author":"Woo","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1170","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/embo-reports\/kvf175","article-title":"Targeted disruption of hsp70.1 sensitizes to osmotic stress","volume":"3","author":"Shim","year":"2002","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jfo.2016.07.006_bib1175","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1167\/iovs.07-1142","article-title":"NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells","volume":"49","author":"Lee","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1400","doi-asserted-by":"crossref","first-page":"e0159983","DOI":"10.1371\/journal.pone.0159983","article-title":"In vitro inhibition of NFAT5-mediated induction of CCL2 in hyperosmotic conditions by cyclosporine and dexamethasone on human HeLa-modified conjunctiva-derived cells","volume":"11","author":"Warcoin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jfo.2016.07.006_bib1185","first-page":"851","article-title":"Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitro","volume":"18","author":"Clouzeau","year":"2012","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2016.07.006_bib1190","doi-asserted-by":"crossref","first-page":"F209","DOI":"10.1152\/ajprenal.2000.278.2.F209","article-title":"Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells","volume":"278","author":"Michea","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1195","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1152\/ajpcell.1996.271.3.C950","article-title":"Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes","volume":"271","author":"Bortner","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1200","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s004410100358","article-title":"A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes","volume":"304","author":"Galvez","year":"2001","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1205","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jfo.2016.07.006_bib1210","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0074-7696(08)62312-8","article-title":"Cell death: the significance of apoptosis","volume":"68","author":"Wyllie","year":"1980","journal-title":"Int Rev Cytol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1215","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/ICO.0b013e318030d259","article-title":"Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways","volume":"26","author":"Luo","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2016.07.006_bib1220","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.exer.2012.12.001","article-title":"Betaine stabilizes cell volume and protects against apoptosis in human corneal epithelial cells under hyperosmotic stress","volume":"108","author":"Garrett","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1225","first-page":"1945","article-title":"Decrease in hyperosmotic stress\u2013induced corneal epithelial cell apoptosis by L-carnitine","volume":"19","author":"Khandekar","year":"2013","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2016.07.006_bib1230","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jcp.22389","article-title":"Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells","volume":"226","author":"Png","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1235","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1167\/iovs.10-6485","article-title":"Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun","volume":"52","author":"Wang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1240","doi-asserted-by":"crossref","first-page":"34966","DOI":"10.1074\/jbc.M502430200","article-title":"Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin","volume":"280","author":"Yang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jfo.2016.07.006_bib1245","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.1073\/pnas.0402961101","article-title":"High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib1250","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1167\/iovs.14-16247","article-title":"Protective effects of L-carnitine against oxidative injury by hyperosmolarity in human corneal epithelial cells","volume":"56","author":"Hua","year":"2015","journal-title":"Invest Opthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1255","first-page":"F786","article-title":"Urea-associated oxidative stress and Gadd153\/CHOP induction","volume":"276","author":"Zhang","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1260","doi-asserted-by":"crossref","first-page":"e0126561","DOI":"10.1371\/journal.pone.0126561","article-title":"Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells","volume":"10","author":"Deng","year":"2015","journal-title":"Plos One"},{"key":"10.1016\/j.jfo.2016.07.006_bib1265","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.exer.2015.02.013","article-title":"Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients","volume":"134","author":"Zheng","year":"2015","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1270","doi-asserted-by":"crossref","first-page":"e72900","DOI":"10.1371\/journal.pone.0072900","article-title":"Effect of reactive oxygen species generation in rabbit corneal epithelial cells on inflammatory and apoptotic signaling pathways in the presence of high osmotic pressure","volume":"8","author":"Chen","year":"2013","journal-title":"Plos One"},{"key":"10.1016\/j.jfo.2016.07.006_bib1275","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1476-9255-6-21","article-title":"Is inflammation a consequence of extracellular hyperosmolarity?","volume":"6","author":"Schwartz","year":"2009","journal-title":"J Inflamm (Lond)"},{"key":"10.1016\/j.jfo.2016.07.006_bib1280","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00011-007-7213-0","article-title":"Hyperosmolarity causes inflammation through the methylation of protein phosphatase 2A","volume":"57","author":"Abolhassani","year":"2008","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1285","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/excr.1997.3476","article-title":"Hyperosmotic stress as a stimulant for proinflammatory cytokine production","volume":"231","author":"Shapiro","year":"1997","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1290","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s00424-001-0768-7","article-title":"Stimulation of TNF alpha expression by hyperosmotic stress","volume":"443","author":"Lang","year":"2002","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jfo.2016.07.006_bib1295","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1056-8727(97)00004-4","article-title":"High glucose and hyperosmolarity increase secretion of interleukin-1 beta in cultured human aortic endothelial cells","volume":"11","author":"Asakawa","year":"1997","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.jfo.2016.07.006_bib1300","doi-asserted-by":"crossref","first-page":"12230","DOI":"10.1073\/pnas.92.26.12230","article-title":"Osmotic regulation of cytokine synthesis in vitro","volume":"92","author":"Shapiro","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jfo.2016.07.006_bib1305","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1046\/j.1440-1843.2002.00401.x","article-title":"p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase regulate interleukin-8 and RANTES production in hyperosmolarity stimulated human bronchial epithelial cells","volume":"7","author":"Furuichi","year":"2002","journal-title":"Respirology"},{"key":"10.1016\/j.jfo.2016.07.006_bib1310","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.exer.2005.08.019","article-title":"JNK and ERK MAP kinases mediate induction of IL-1\u03b2, TNF-\u03b1 and IL-8 following hyperosmolar stress in human limbal epithelial cells","volume":"82","author":"Li","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1315","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0002-9440(10)64259-9","article-title":"Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells","volume":"161","author":"N\u00e9meth","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1320","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1164\/ajrccm.159.2.9712090","article-title":"Hyperosmolarity-induced interleukin-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase","volume":"159","author":"Hashimoto","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jfo.2016.07.006_bib1325","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3109\/02713683.2014.957776","article-title":"Effects of l-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress","volume":"40","author":"Hua","year":"2015","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1330","first-page":"1115","article-title":"17-\u03b2-estradiol inhibits hyperosmolarity-induced proinflammatory cytokine elevation via the p38 MAPK pathway in human corneal epithelial cells","volume":"18","author":"Wang","year":"2012","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2016.07.006_bib1335","first-page":"533","article-title":"Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells","volume":"17","author":"Cavet","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2016.07.006_bib1340","first-page":"1791","article-title":"Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells","volume":"16","author":"Cavet","year":"2010","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2016.07.006_bib1345","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1167\/iovs.04-0299","article-title":"Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells","volume":"45","author":"Li","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1350","first-page":"1243","article-title":"Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells","volume":"20","author":"Deng","year":"2014","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2016.07.006_bib1355","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.ajpath.2011.05.036","article-title":"EMMPRIN modulates epithelial barrier function through a MMP-mediated occludin cleavage: implications in dry eye disease","volume":"179","author":"Huet","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jfo.2016.07.006_bib1360","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1167\/iovs.07-0569","article-title":"Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK","volume":"49","author":"Chen","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1365","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/ICO.0b013e318165b19e","article-title":"Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells","volume":"27","author":"Corrales","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2016.07.006_bib1370","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.exer.2009.12.004","article-title":"Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways","volume":"90","author":"Chen","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2016.07.006_bib1375","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1167\/iovs.13-12459","article-title":"Effect of nerve growth factor on the in vitro induction of apoptosis of human conjunctival epithelial cells by hyperosmolar stress","volume":"55","author":"Kang","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1380","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1167\/iovs.11-7215","article-title":"Hyperosmolar stress upregulates HLA-DR expression in human conjunctival epithelium in dry eye patients and in vitro models","volume":"52","author":"Versura","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2016.07.006_bib1385","article-title":"Hyperosmolarity and benzalkonium chloride differently stimulate inflammatory markers on conjunctiva-derived epithelial cells in vitro","author":"Warcoin","year":"2016","journal-title":"Ophthalmic research"},{"key":"10.1016\/j.jfo.2016.07.006_bib1390","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/01.ICL.0000162759.79740.46","article-title":"Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface","volume":"31","author":"Luo","year":"2005","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.jfo.2016.07.006_bib1395","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1515\/bmc-2012-0001","article-title":"The role of hyperosmotic stress in inflammation and disease","volume":"3","author":"Brocker","year":"2012","journal-title":"Biomol Concepts"},{"key":"10.1016\/j.jfo.2016.07.006_bib0700","doi-asserted-by":"crossref","first-page":"584","DOI":"10.2174\/138920210793360961","article-title":"Role of NFAT5 in inflammatory disorders associated with osmotic stress","volume":"11","author":"Neuhofer","year":"2010","journal-title":"Curr Genomics"}],"container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551216301693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551216301693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T19:06:19Z","timestamp":1759259179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0181551216301693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":140,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0181551216301693"],"URL":"https:\/\/doi.org\/10.1016\/j.jfo.2016.07.006","relation":{},"ISSN":["0181-5512"],"issn-type":[{"value":"0181-5512","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperosmolarit\u00e9\u00a0: effets intracellulaires et implication dans la s\u00e9cheresse oculaire","name":"articletitle","label":"Article Title"},{"value":"Journal Fran\u00e7ais d'Ophtalmologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfo.2016.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}