{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:44:25Z","timestamp":1790228665751,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jfo.2025.104433","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T08:16:12Z","timestamp":1739780172000},"page":"104433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Physiopathologie et prise en charge des k\u00e9ratites herp\u00e9tiques li\u00e9es aux virus herpes simplex r\u00e9sistants \u00e0 l\u2019aciclovir"],"prefix":"10.1016","volume":"48","author":[{"given":"R.","family":"Boucher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Boutolleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Burrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Haigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Barreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Benali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meziou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Labetoulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfo.2025.104433_bib0005","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/09286586.2021.1962919","article-title":"Incidence of herpes simplex virus keratitis and other ocular disease: global review and estimates","volume":"29","author":"McCormick","year":"2022","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1016\/j.jfo.2025.104433_bib0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jtos.2021.07.002","article-title":"Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: facts for the clinician","volume":"28","author":"Labetoulle","year":"2023","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jfo.2025.104433_bib0015","series-title":"Herpes Simplex Virus Keratitis: a treatment guideline. Secondary Herpes Simplex Virus Keratitis: a treatment guideline","author":"Lee","year":"2014"},{"key":"10.1016\/j.jfo.2025.104433_bib0020","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1001\/archopht.118.8.1030","article-title":"Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis","volume":"118","author":"Herpetic eye disease study group (HEDSG)","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0025","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1056\/NEJM199807303390503","article-title":"Acyclovir for the prevention of recurrent herpes simplex virus eye disease","volume":"339","author":"Wilhelmus","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfo.2025.104433_bib0030","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0002-9394(14)75589-8","article-title":"Interferon treatment of herpetic keratitis in a patient with acquired immunodeficiency syndrome","volume":"109","author":"McLeish","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.antiviral.2017.09.013","article-title":"Recurrent herpetic keratitis despite antiviral prophylaxis: a virological and pharmacological study","volume":"146","author":"Rousseau","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jfo.2025.104433_bib0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajo.2022.01.010","article-title":"Acyclovir-resistant herpes simplex virus 1\u00a0keratitis: a concerning and emerging clinical challenge","volume":"238","author":"Rousseau","year":"2022","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.jfo.2025.104433_bib0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/ICO.0000000000003553","article-title":"Efficacy and safety of amenamevir, a helicase-primase inhibitor for the treatment of acyclovir-resistant herpes simplex virus 1 keratitis","volume":"44","author":"Boucher","year":"2025","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2025.104433_bib0050","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1080\/21505594.2021.1982373","article-title":"Pathogenesis and virulence of herpes simplex virus","volume":"12","author":"Zhu","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.jfo.2025.104433_bib0055","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1001\/archopht.1989.01070020226030","article-title":"Epidemiology of ocular herpes simplex. Natural history in Rochester, Minn, 1950\u00a0through 1982","volume":"107","author":"Liesegang","year":"1989","journal-title":"Arch Ophthalmol"},{"issue":"24","key":"10.1016\/j.jfo.2025.104433_bib0060","doi-asserted-by":"crossref","first-page":"e01586","DOI":"10.1128\/JVI.01586-19","article-title":"Herpes simplex virus 1 replication, ocular disease, and reactivations from latency are restricted unilaterally after inoculation of virus into the lip","volume":"93","author":"Poccardi","year":"2019","journal-title":"J Virol"},{"key":"10.1016\/j.jfo.2025.104433_bib0065","first-page":"415","article-title":"Latence et r\u00e9activation de HSV1, LAT et ICP0: les deux faces d\u2019une seule m\u00e9daille","volume":"10","author":"Cr\u00e9pin","year":"2006","journal-title":"Virol"},{"issue":"1","key":"10.1016\/j.jfo.2025.104433_bib0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3390\/v15010225","article-title":"A comprehensive overview of epidemiology, pathogenesis and the management of herpes labialis","volume":"15","author":"Gopinath","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.jfo.2025.104433_bib0075","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature11583","article-title":"Impaired intrinsic immunity to HSV-1\u00a0in human iPSC-derived TLR3-deficient CNS cells","volume":"491","author":"Lafaille","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jfo.2025.104433_bib0080","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/archophthalmol.2010.187","article-title":"Incidence, recurrence, and outcomes of herpes simplex virus eye disease in Olmsted County, Minnesota, 1976\u20132007: the effect of oral antiviral prophylaxis","volume":"128","author":"Young","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0085","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ophtha.2016.10.001","article-title":"Persistent impairment of quality of life in patients with herpes simplex keratitis","volume":"124","author":"Reynaud","year":"2017","journal-title":"Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0090","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/exer.2000.0886","article-title":"Acyclovir-resistant bilateral keratitis associated with mutations in the HSV-1\u00a0thymidine kinase gene","volume":"71","author":"Bodaghi","year":"2000","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2025.104433_bib0095","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.survophthal.2012.01.005","article-title":"Herpes simplex epithelial and stromal keratitis: an epidemiologic update","volume":"57","author":"Farooq","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0100","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/00003226-200310001-00008","article-title":"Quantitative analysis of herpes simplex virus genome in tears from patients with herpetic keratitis","volume":"22","author":"Fukuda","year":"2003","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2025.104433_bib0105","doi-asserted-by":"crossref","first-page":"e0088523","DOI":"10.1128\/jcm.00885-23","article-title":"Diagnostic performance of real-time quantitative PCR in tear samples in various subtypes of herpes simplex keratitis","volume":"61","author":"Hoarau","year":"2023","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jfo.2025.104433_bib0110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00003226-199903000-00001","article-title":"Classification of herpes simplex virus keratitis and anterior uveitis","volume":"18","author":"Liesegang","year":"1999","journal-title":"Cornea"},{"issue":"5","key":"10.1016\/j.jfo.2025.104433_bib0115","doi-asserted-by":"crossref","first-page":"e02035","DOI":"10.1128\/JVI.02035-19","article-title":"RNA polymerase ii promoter-proximal pausing and release to elongation are key steps regulating herpes simplex virus 1 transcription","volume":"94","author":"Birkenheuer","year":"2020","journal-title":"J Virol"},{"key":"10.1016\/j.jfo.2025.104433_bib0120","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1073\/pnas.77.4.2265","article-title":"Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1","volume":"77","author":"Coen","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.jfo.2025.104433_bib0125","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/v13071228","article-title":"Current drugs to treat infections with herpes simplex viruses-1 and -2","volume":"13","author":"Sadowski","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jfo.2025.104433_bib0130","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/rmv.1787","article-title":"Antiviral drug resistance in herpesviruses other than cytomegalovirus","volume":"24","author":"Piret","year":"2014","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.jfo.2025.104433_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-405880-4.00001-9","article-title":"Antiviral agents for herpes simplex virus","volume":"67","author":"Vere Hodge","year":"2013","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.jfo.2025.104433_bib0140","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/cid\/ciad709","article-title":"Treatment for first cytomegalovirus infection post-hematopoietic cell transplant in the aurora trial: a multicenter, double-blind, randomized, phase 3\u00a0trial comparing maribavir with valganciclovir","volume":"78","author":"Papanicolaou","year":"2024","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jfo.2025.104433_bib0145","first-page":"CD002898","article-title":"Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis","volume":"1","author":"Wilhelmus","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jfo.2025.104433_bib0150","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/ICO.0000000000001917","article-title":"Successful management of herpes simplex keratitis with oral valganciclovir in patients unresponsive or allergic to conventional antiviral therapy","volume":"38","author":"Koseoglu","year":"2019","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2025.104433_bib0155","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s40121-022-00746-1","article-title":"New insights on cmv management in solid organ transplant patients: prevention, treatment, and management of resistant\/refractory disease","volume":"12","author":"Kotton","year":"2023","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.jfo.2025.104433_bib0160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/0366-6999.147808","article-title":"Clinical efficacy of oral ganciclovir for prophylaxis and treatment of recurrent herpes simplex keratitis","volume":"128","author":"Wang","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jfo.2025.104433_bib0165","unstructured":"HAS. Avis de la comission de transparence, valganciclovir. Secondary Avis de la comission de transparence, valganciclovir 2018. https:\/\/www.has-sante.fr\/upload\/docs\/evamed\/CT-17146_ROVALCYTE_PIS_RI_AVIS2_CT17146.pdf."},{"key":"10.1016\/j.jfo.2025.104433_bib0170","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/tri.13558","article-title":"Effects of valganciclovir on spermatogenesis in renal transplant patients\u00a0\u2013\u00a0results of a multicenter prospective nonrandomized study","volume":"33","author":"McLeroth","year":"2020","journal-title":"Transpl Int"},{"key":"10.1016\/j.jfo.2025.104433_bib0175","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1167\/iovs.10-5671","article-title":"In vitro synergism of trifluorothymidine and ganciclovir against HSV-1","volume":"52","author":"Hobden","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jfo.2025.104433_bib0180","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cmi.2023.03.020","article-title":"Oral antiviral drugs for treatment of cytomegalovirus in transplant recipients","volume":"29","author":"Razonable","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jfo.2025.104433_bib0185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1099\/0022-1317-49-1-115","article-title":"Isolation and characterization of acyclovir-resistant mutants of herpes simplex virus","volume":"49","author":"Field","year":"1980","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jfo.2025.104433_bib0190","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcv.2013.05.001","article-title":"Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1\u00a0isolates from immunocompetent patients with recurrent herpetic keratitis","volume":"58","author":"Burrel","year":"2013","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jfo.2025.104433_bib0195","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1442-9071.2010.02209.x","article-title":"Aciclovir-resistant herpes keratitis","volume":"38","author":"Choong","year":"2010","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0200","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2147\/OPTH.S39113","article-title":"Acyclovir-resistant herpetic keratitis in a solid-organ transplant recipient on systemic immunosuppression","volume":"7","author":"Turner","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0205","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/infdis\/jit350","article-title":"Acyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis","volume":"208","author":"van Velzen","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfo.2025.104433_bib0210","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/590668","article-title":"Acyclovir-resistant corneal HSV-1\u00a0isolates from patients with herpetic keratitis","volume":"198","author":"Duan","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfo.2025.104433_bib0215","doi-asserted-by":"crossref","first-page":"101268","DOI":"10.1016\/j.ajoc.2022.101268","article-title":"Putting drug resistant epithelial herpes keratitis in the spotlight: a case series","volume":"25","author":"De Clerck","year":"2022","journal-title":"Am J Ophthalmol Case Rep"},{"key":"10.1016\/j.jfo.2025.104433_bib0220","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000368297","article-title":"Necrotizing keratitis caused by acyclovir-resistant herpes simplex virus","volume":"5","author":"Toriyama","year":"2014","journal-title":"Case Rep Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0225","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/AAC.42.4.868","article-title":"Survey of resistance of herpes simplex virus to acyclovir in Northwest England","volume":"42","author":"Christophers","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jfo.2025.104433_bib0230","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1086\/606028","article-title":"Acyclovir susceptibility and genetic characteristics of sequential herpes simplex virus type 1\u00a0corneal isolates from patients with recurrent herpetic keratitis","volume":"200","author":"Duan","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfo.2025.104433_bib0235","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.enz.2021.09.003","article-title":"Herpesvirus DNA polymerase: structures, functions, and mechanisms","volume":"50","author":"Coen","year":"2021","journal-title":"Enzymes"},{"key":"10.1016\/j.jfo.2025.104433_bib0240","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1128\/AAC.00669-10","article-title":"Genotypic characterization of UL23\u00a0thymidine kinase and UL30\u00a0DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals","volume":"54","author":"Burrel","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jfo.2025.104433_bib0245","first-page":"325","article-title":"Herpes simplex virus resistance to antivirals","volume":"24","author":"Burrel","year":"2020","journal-title":"Virol (Montrouge)"},{"key":"10.1016\/j.jfo.2025.104433_bib0250","doi-asserted-by":"crossref","first-page":"6817","DOI":"10.1128\/JVI.00166-07","article-title":"Diverse herpes simplex virus type 1\u00a0thymidine kinase mutants in individual human neurons and ganglia","volume":"81","author":"Wang","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.jfo.2025.104433_bib0255","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.virol.2021.01.016","article-title":"Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1\u00a0thymidine kinase substitution mutant with reduced neuronal replication","volume":"556","author":"Wang","year":"2021","journal-title":"Virol"},{"key":"10.1016\/j.jfo.2025.104433_bib0260","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/QCO.0000000000000288","article-title":"Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management","volume":"29","author":"Piret","year":"2016","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jfo.2025.104433_bib0265","first-page":"125","article-title":"Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised","volume":"79","author":"Tan","year":"2012","journal-title":"Neurol"},{"key":"10.1016\/j.jfo.2025.104433_bib0270","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.antiviral.2014.08.013","article-title":"Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France","volume":"111","author":"Frobert","year":"2014","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jfo.2025.104433_bib0275","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/infdis\/jit437","article-title":"Common and new acyclovir resistant herpes simplex virus-1\u00a0mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient","volume":"209","author":"Pan","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jfo.2025.104433_bib0285","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10384-007-0485-7","article-title":"Clinical application of real-time polymerase chain reaction for diagnosis of herpetic diseases of the anterior segment of the eye","volume":"52","author":"Kakimaru-Hasegawa","year":"2008","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104433_bib0280","unstructured":"Bodaghi B, Bourcier T, Labetoulle M. Infections en ophtalmologie - rapport SFO 2024, 2024."},{"key":"10.1016\/j.jfo.2025.104433_bib0290","doi-asserted-by":"crossref","first-page":"105950","DOI":"10.1016\/j.antiviral.2024.105950","article-title":"CRISPR\/Cas9-mediated genome editing of the thymidine kinase gene in a clinical HSV-1\u00a0isolate identifies F289S as novel acyclovir-resistant mutation","volume":"228","author":"Zheng","year":"2024","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jfo.2025.104433_bib0295","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/1120009X.2021.1915074","article-title":"Relationship between renal dysfunction and electrolyte abnormalities in hematopoietic stem cell transplant patients treated with foscarnet","volume":"33","author":"Ota","year":"2021","journal-title":"J Chemother"},{"key":"10.1016\/j.jfo.2025.104433_bib0300","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1755-3768.1992.tb02154.x","article-title":"Phosphonoformate (foscarnet, PFA) versus trifluorthymidine in the treatment of keratitis dendritica in the human. A double-blind, randomized, preliminary trial","volume":"70","author":"Behrens-Baumann","year":"1992","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"10.1016\/j.jfo.2025.104433_bib0305","doi-asserted-by":"crossref","first-page":"210011","DOI":"10.1098\/rsob.210011","article-title":"The three-component helicase\/primase complex of herpes simplex virus-1","volume":"11","author":"Bermek","year":"2021","journal-title":"Open Biol"},{"issue":"3","key":"10.1016\/j.jfo.2025.104433_bib0310","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/1346-8138.16608","article-title":"A phase 3, randomized, double-blind, placebo-controlled study evaluating a single, patient-initiated dose of amenamevir for recurrent herpes labialis","volume":"50","author":"Kawashima","year":"2023","journal-title":"J Dermatol"},{"key":"10.1016\/j.jfo.2025.104433_bib0315","doi-asserted-by":"crossref","DOI":"10.3390\/v13081547","article-title":"Amenamevir, a helicase-primase inhibitor, for the optimal treatment of herpes zoster","volume":"13","author":"Shiraki","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jfo.2025.104433_bib0320","doi-asserted-by":"crossref","first-page":"ofac494","DOI":"10.1093\/ofid\/ofac494","article-title":"Single-dose, patient-initiated amenamevir therapy for recurrent genital herpes: a phase 3, randomized, double-blind, placebo-controlled study","volume":"9","author":"Kawashima","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jfo.2025.104433_bib0325","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1021\/acs.jmedchem.2c00668","article-title":"Discovery, chemistry, and preclinical development of pritelivir, a novel treatment option for acyclovir-resistant herpes simplex virus infections","volume":"65","author":"Birkmann","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.jfo.2025.104433_bib0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2017.11.002","article-title":"Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis","volume":"149","author":"Quenelle","year":"2018","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jfo.2025.104433_bib0335","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1056\/NEJMoa1301150","article-title":"Helicase-primase inhibitor pritelivir for HSV-2\u00a0infection","volume":"370","author":"Wald","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jfo.2025.104433_bib0340","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1001\/jama.2016.18189","article-title":"Effect of pritelivir compared with valacyclovir on genital HSV-2\u00a0shedding in patients with frequent recurrences: a randomized clinical trial","volume":"316","author":"Wald","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jfo.2025.104433_bib0345","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/cpdd.1241","volume":"12","author":"Kropeit","year":"2023","journal-title":"Clin Pharmacol Drug Dev"},{"key":"10.1016\/j.jfo.2025.104433_bib0350","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S1542-0124(12)70614-6","article-title":"Evidence-based treatment of herpes simplex virus keratitis: a systematic review","volume":"5","author":"Guess","year":"2007","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jfo.2025.104433_bib0355","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3851\/IMP3254","article-title":"Antiviral effects of Cacicol(\u00ae), a heparan sulfate biomimetic for corneal regeneration therapy, for herpes simplex virus type-1\u00a0and varicella zoster virus infection","volume":"23","author":"Deback","year":"2018","journal-title":"Antivir Ther"},{"issue":"1","key":"10.1016\/j.jfo.2025.104433_bib0360","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12985-024-02384-0","article-title":"Harmol used for the treatment of herpes simplex virus induced keratitis","volume":"21","author":"Xu","year":"2024","journal-title":"Virol J"},{"issue":"21","key":"10.1016\/j.jfo.2025.104433_bib0365","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.3390\/molecules28217375","article-title":"Large subunit of the human herpes simplex virus terminase as a promising target in design of anti-herpesvirus agents","volume":"28","author":"Krasnov","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jfo.2025.104433_bib0370","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12929-024-01045-2","article-title":"Development of a highly effective combination monoclonal antibody therapy against herpes simplex virus","volume":"31","author":"Seyfizadeh","year":"2024","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jfo.2025.104433_bib0375","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jtos.2020.11.001","article-title":"Herpes Simplex Virus-1\u00a0infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis","volume":"19","author":"Guan","year":"2021","journal-title":"Ocul Surf"},{"key":"10.1016\/j.jfo.2025.104433_bib0380","doi-asserted-by":"crossref","first-page":"S7-s18","DOI":"10.1097\/ICO.0000000000002425","article-title":"Adoption of innovation in herpes simplex virus keratitis","volume":"39","author":"Chodosh","year":"2020","journal-title":"Cornea"}],"container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551225000154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551225000154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T16:33:35Z","timestamp":1744389215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0181551225000154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0181551225000154"],"URL":"https:\/\/doi.org\/10.1016\/j.jfo.2025.104433","relation":{},"ISSN":["0181-5512"],"issn-type":[{"value":"0181-5512","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiopathologie et prise en charge des k\u00e9ratites herp\u00e9tiques li\u00e9es aux virus herpes simplex r\u00e9sistants \u00e0 l\u2019aciclovir","name":"articletitle","label":"Article Title"},{"value":"Journal Fran\u00e7ais d'Ophtalmologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfo.2025.104433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104433"}}