{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:00:00Z","timestamp":1773270000279,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004077","name":"Kocaeli University","doi-asserted-by":"publisher","award":["2013\/028"],"award-info":[{"award-number":["2013\/028"]}],"id":[{"id":"10.13039\/501100004077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jfo.2025.104667","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T17:03:06Z","timestamp":1761325386000},"page":"104667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of quercetin as an alternative to riboflavin in collagen cross-linking treatment"],"prefix":"10.1016","volume":"48","author":[{"given":"B.","family":"Katre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6.","family":"Alt\u0131nta\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Emre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"\u015e\u0131k Sarman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kasap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.K.","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-8449","authenticated-orcid":false,"given":"M.","family":"Toprak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Y\u0131lmaz Tu\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jfo.2025.104667_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92133-y","article-title":"Corneal transplantation for keratoconus in South Korea","volume":"11","author":"Hwang","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jfo.2025.104667_bib0010","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/01.icu.0000233954.86723.25","article-title":"Cross-linking treatment of progressive keratoconus: new hope","volume":"17","author":"Wollensak","year":"2006","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104667_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1755-3768.2008.01190.x","article-title":"Long-term biomechanical properties of rabbit cornea after photodynamic collagen cross-linking","volume":"87","author":"Wollensak","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104667_bib0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00003226-200401000-00008","article-title":"Keratocyte apoptosis after corneal collagen cross-linking using riboflavin\/UVA treatment","volume":"23","author":"Wollensak","year":"2004","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2025.104667_bib0025","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/sj.eye.6700751","article-title":"Keratocyte cytotoxicity of riboflavin\/UVA-treatment in vitro","volume":"18","author":"Wollensak","year":"2004","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.jfo.2025.104667_bib0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13318-014-0206-9","article-title":"Comparative pharmacokinetic interactions of quercetin and rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of quercetin and rutin","volume":"40","author":"Kammalla","year":"2015","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.jfo.2025.104667_bib0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.actbio.2009.07.035","article-title":"Quercetin-crosslinked porcine heart valve matrix: mechanical properties, stability, anticalcification and cytocompatibility","volume":"6","author":"Zhai","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jfo.2025.104667_bib0040","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0891-5849(96)00351-6","article-title":"Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships","volume":"22","author":"Cao","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jfo.2025.104667_bib0045","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jphotobiol.2009.08.009","article-title":"UVA and UVB radiation-induced oxidation products of quercetin","volume":"97","author":"Fahlman","year":"2009","journal-title":"J Photochem Photobiol B"},{"key":"10.1016\/j.jfo.2025.104667_bib0050","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-3835(97)04644-2","article-title":"Bioavailability of the dietary antioxidant flavonol quercetin in man","volume":"114","author":"Hollman","year":"1997","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jfo.2025.104667_bib0055","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.lfs.2008.05.009","article-title":"Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: a model experiment","volume":"83","author":"Sakanashi","year":"2008","journal-title":"Life Sci"},{"key":"10.1016\/j.jfo.2025.104667_bib0190","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2230.2001.00884.x","article-title":"Beneficial effects of quercetin on oxidative stress induced by ultraviolet A","volume":"26","author":"Erden Inal","year":"2001","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jfo.2025.104667_bib0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1751-1097.1985.tb03551.x","article-title":"O2- -dependent and -independent photooxidation of quercetin in the presence and absence of riboflavin and effects of ascorbate on the photooxidation","volume":"42","author":"Takahama","year":"1985","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.jfo.2025.104667_bib0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1751-1097.2010.00754.x","article-title":"Stability of flavonoids in the presence of riboflavin-photogenerated reactive oxygen species: a kinetic and mechanistic study on quercetin, morin and rutin","volume":"86","author":"Monta\u00f1a","year":"2010","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.jfo.2025.104667_bib0070","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00424-013-1235-y","article-title":"Quercetin as a fluorescent probe for the ryanodine receptor activity in Jurkat cells","volume":"465","author":"Baran","year":"2013","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jfo.2025.104667_bib0075","series-title":"A Latin dictionary founded on Andrews\u2019 edition of Freund's Latin dictionary","author":"Andrews","year":"1896"},{"key":"10.1016\/j.jfo.2025.104667_bib0080","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0891-5849(96)00351-6","article-title":"Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships","volume":"22","author":"Cao","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jfo.2025.104667_bib0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jphotobiol.2009.08.009","article-title":"UVA and UVB radiation-induced oxidation products of quercetin","volume":"97","author":"Fahlman","year":"2009","journal-title":"J Photochem Photobiol B"},{"key":"10.1016\/j.jfo.2025.104667_bib0090","doi-asserted-by":"crossref","first-page":"e201700377","DOI":"10.1002\/jbio.201700377","article-title":"Ultraviolet radiation oxidative stress affects eye health","volume":"11","author":"Ivanov","year":"2018","journal-title":"J Biophotonics"},{"key":"10.1016\/j.jfo.2025.104667_bib0095","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jfo.2025.104667_bib0100","doi-asserted-by":"crossref","first-page":"19294","DOI":"10.3390\/ijms140919294","article-title":"Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy","volume":"14","author":"Wojcik","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jfo.2025.104667_bib0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/002215540205000306","article-title":"Evidence of oxidative stress in human corneal diseases","volume":"50","author":"Buddi","year":"2002","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jfo.2025.104667_bib0110","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/molecules24061123","article-title":"Antioxidant activities of quercetin and its complexes for medicinal application","volume":"24","author":"Xu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jfo.2025.104667_bib0115","doi-asserted-by":"crossref","first-page":"6545","DOI":"10.3390\/molecules27196545","article-title":"Quercetin: its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy","volume":"27","author":"Qi","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jfo.2025.104667_bib0120","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3390\/antiox12071326","article-title":"Potential therapeutic functions of PU-91 and quercetin in personalized cybrids derived from patients with age-related macular degeneration, keratoconus, and glaucoma","volume":"12","author":"Salimiaghdam","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jfo.2025.104667_bib0125","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1038\/srep09003","article-title":"Quercetin attenuates lactate production and extracellular matrix secretion in keratoconus","volume":"5","author":"McKay","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jfo.2025.104667_bib0130","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.exer.2011.01.008","article-title":"Differential epithelial and stromal protein profiles in keratoconus and normal human corneas","volume":"92","author":"Joseph","year":"2011","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.jfo.2025.104667_bib0135","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ajo.2010.11.008","article-title":"Transforming growth factor-\u03b2 signaling pathway activation in Keratoconus","volume":"151","author":"Engler","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jfo.2025.104667_bib0140","first-page":"1198","article-title":"Active transforming growth factor-beta2 is increased in the aqueous humor of keratoconus patients","volume":"13","author":"Maier","year":"2007","journal-title":"Mol Vis"},{"key":"10.1016\/j.jfo.2025.104667_bib0145","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.actbio.2009.07.035","article-title":"Quercetin-crosslinked porcine heart valve matrix: mechanical properties, stability, anticalcification and cytocompatibility","volume":"6","author":"Zhai","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jfo.2025.104667_bib0150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00347-002-0700-3","article-title":"Behandlung von Keratokonus durch Kollagenvernetzung [Treatment of keratoconus by collagen cross-linking]","volume":"100","author":"Wollensak","year":"2003","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.jfo.2025.104667_bib0155","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00424-013-1235-y","article-title":"Quercetin as a fluorescent probe for the ryanodine receptor activity in Jurkat cells","volume":"465","author":"Baran","year":"2013","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jfo.2025.104667_bib0160","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/ICO.0b013e3181bdf1cc","article-title":"Immunofluorescence of rabbit corneas after collagen cross-linking treatment with riboflavin and ultraviolet A","volume":"29","author":"Esquenazi","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2025.104667_bib0165","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/ICO.0b013e318041f073","article-title":"Wound healing in the rabbit cornea after corneal collagen cross-linking with riboflavin and UVA","volume":"26","author":"Wollensak","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.jfo.2025.104667_bib0170","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","article-title":"Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking","volume":"29","author":"Wollensak","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.jfo.2025.104667_bib0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jcrs.2005.12.092","article-title":"Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light","volume":"32","author":"Kohlhaas","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.jfo.2025.104667_bib0180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/exer.1997.0410","article-title":"Induction of cross-links in corneal tissue","volume":"66","author":"Spoerl","year":"1998","journal-title":"Exp Eye Res"}],"container-title":["Journal Fran\u00e7ais d'Ophtalmologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551225002499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0181551225002499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:41:34Z","timestamp":1773214894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0181551225002499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0181551225002499"],"URL":"https:\/\/doi.org\/10.1016\/j.jfo.2025.104667","relation":{},"ISSN":["0181-5512"],"issn-type":[{"value":"0181-5512","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of quercetin as an alternative to riboflavin in collagen cross-linking treatment","name":"articletitle","label":"Article Title"},{"value":"Journal Fran\u00e7ais d'Ophtalmologie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jfo.2025.104667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104667"}}