{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:57:22Z","timestamp":1790261842917,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004083","name":"Ministry of Science ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-017M3A9E4078009"],"award-info":[{"award-number":["NRF-017M3A9E4078009"]}],"id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004083","name":"Ministry of Science ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2017M3A9E4078014"],"award-info":[{"award-number":["NRF-2017M3A9E4078014"]}],"id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2017-ER5404-01"],"award-info":[{"award-number":["2017-ER5404-01"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.jgar.2018.05.021","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T06:00:03Z","timestamp":1527314403000},"page":"302-305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["PNGM-1, a novel subclass B3 metallo-\u03b2-lactamase from a deep-sea sediment metagenome"],"prefix":"10.1016","volume":"14","author":[{"given":"Kwang Seung","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Yeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Ho","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad Mustafa","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumera Kausar","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-7122","authenticated-orcid":false,"given":"Sang Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2018.05.021_bib0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1749-6632.2012.06796.x","article-title":"Metallo-\u03b2-lactamase structure and function","volume":"1277","author":"Palzkill","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jgar.2018.05.021_bib0010","doi-asserted-by":"crossref","first-page":"9654","DOI":"10.3390\/ijms16059654","article-title":"Structural basis for carbapenem-hydrolyzing mechanisms of carbapenemases conferring antibiotic resistance","volume":"16","author":"Jeon","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jgar.2018.05.021_bib0015","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1128\/AAC.00568-10","article-title":"Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-\u03b2-lactam \u03b2-lactamase inhibitor","volume":"54","author":"Stachyra","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2018.05.021_bib0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","article-title":"Three decades of \u03b2-lactamase inhibitors","volume":"23","author":"Drawz","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jgar.2018.05.021_bib0025","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.2174\/092986709789104957","article-title":"\u03b2-Lactamase inhibitors: the story so far","volume":"16","author":"Perez-Llarena","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jgar.2018.05.021_bib0030","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1128\/AAC.45.3.660-663.2001","article-title":"Standard numbering scheme for class B \u03b2-lactamases","volume":"45","author":"Galleni","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2018.05.021_bib0035","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1473-3099(15)00467-3","article-title":"How to minimise antibiotic resistance","volume":"16","author":"Lee","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2018.05.021_bib0040","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1128\/AAC.45.3.837-844.2001","article-title":"Metallo-\u03b2-lactamase producers in environmental microbiota: new molecular class B enzyme in Janthinobacterium lividum","volume":"45","author":"Rossolini","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2018.05.021_bib0045","doi-asserted-by":"crossref","first-page":"R245","DOI":"10.1016\/S1074-5521(98)90108-9","article-title":"Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products","volume":"5","author":"Handelsman","year":"1998","journal-title":"Chem Biol"},{"key":"10.1016\/j.jgar.2018.05.021_bib0050","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ismej.2008.86","article-title":"Functional metagenomics reveals diverse \u03b2-lactamases in a remote Alaskan soil","volume":"3","author":"Allen","year":"2009","journal-title":"ISME J"},{"key":"10.1016\/j.jgar.2018.05.021_bib0055","first-page":"172","article-title":"Molecular characterization of TEM-type \u03b2-lactamases identified in cold-seep sediments of Edison Seamount (south of Lihir Island, Papua New Guinea)","volume":"43","author":"Song","year":"2005","journal-title":"J Microbiol"},{"key":"10.1016\/j.jgar.2018.05.021_bib0060","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1128\/AAC.00750-16","article-title":"Structural and biochemical characterization of Rm3, a subclass B3 metallo-\u03b2-lactamase identified from a functional metagenomic study","volume":"60","author":"Salimraj","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2018.05.021_bib0065","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3389\/fmicb.2016.01985","article-title":"Expanding the repertoire of carbapenem-hydrolyzing metallo-\u03b2-lactamases by functional metagenomic analysis of soil microbiota","volume":"7","author":"Gudeta","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2018.05.021_bib0070","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1128\/AEM.01763-09","article-title":"Metagenomic analysis of apple orchard soil reveals antibiotic resistance genes encoding predicted bifunctional proteins","volume":"76","author":"Donato","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jgar.2018.05.021_bib0075","doi-asserted-by":"crossref","first-page":"271419","DOI":"10.1155\/2011\/271419","article-title":"Novel lipolytic enzymes identified from metagenomic library of deep-sea sediment","volume":"2011","author":"Jeon","year":"2011","journal-title":"Evid Based Complement Altern Med"},{"key":"10.1016\/j.jgar.2018.05.021_bib0080","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1107\/S1399004714019543","article-title":"Structure of ADC-68, a novel carbapenem-hydrolyzing class C extended-spectrum \u03b2-lactamase isolated from Acinetobacter baumannii","volume":"70","author":"Jeon","year":"2014","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.jgar.2018.05.021_bib0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgar.2018.05.021_bib0090","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1128\/AAC.00041-11","article-title":"Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach","volume":"55","author":"Park","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2018.05.021_bib0095","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.jgar.2018.05.021_bib0100","series-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard","author":"Clinical and Laboratory Standards Institute","year":"2015"},{"key":"10.1016\/j.jgar.2018.05.021_bib0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2958.1987.tb00523.x","article-title":"Sensitivity of Escherichia coli to various \u03b2-lactams is determined by the interplay of outer membrane permeability and degradation by periplasmic \u03b2-lactamases: a quantitative predictive treatment","volume":"1","author":"Nikaido","year":"1987","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jgar.2018.05.021_bib0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/abio.1996.0238","article-title":"Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase","volume":"237","author":"Kuzmic","year":"1996","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jgar.2018.05.021_bib0115","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1128\/AAC.05305-11","article-title":"The class A \u03b2-lactamase FTU-1 is native to Francisella tularensis","volume":"56","author":"Antunes","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2018.05.021_bib0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0009-2541(01)00419-3","article-title":"Seeing hydrocarbons and related carbonate mineralisations in sediments south of Lihir Island (New Ireland fore-arc basin, Papua New Guinea)","volume":"186","author":"Schimidt","year":"2002","journal-title":"Chem Geol"},{"key":"10.1016\/j.jgar.2018.05.021_bib0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10388","article-title":"Antibiotic resistance is ancient","volume":"477","author":"D\u2019Costa","year":"2011","journal-title":"Nature"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221371651830105X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221371651830105X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:54:41Z","timestamp":1761990881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221371651830105X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":25,"alternative-id":["S221371651830105X"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2018.05.021","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PNGM-1, a novel subclass B3 metallo-\u03b2-lactamase from a deep-sea sediment metagenome","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2018.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}