{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:27:38Z","timestamp":1763141258531,"version":"build-2065373602"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jgar.2019.11.011","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T11:24:19Z","timestamp":1574508259000},"page":"252-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The impact of serum protein binding on bacterial killing of minocycline"],"prefix":"10.1016","volume":"21","author":[{"given":"Li-Xia","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly R.","family":"Ledesma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Merlau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent H.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2019.11.011_bib0005","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/2049-632X.12125","article-title":"Acinetobacter baumannii: evolution of a global pathogen","volume":"71","author":"Antunes","year":"2014","journal-title":"Pathog Dis"},{"key":"10.1016\/j.jgar.2019.11.011_bib0010","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s12275-016-6146-0","article-title":"Epidemiology and resistance features of Acinetobacter baumannii isolates from the ward environment and patients in the burn ICU of a Chinese hospital","volume":"54","author":"Gong","year":"2016","journal-title":"J Microbiol"},{"key":"10.1016\/j.jgar.2019.11.011_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-0711-12-24","article-title":"Antimicrobial susceptibility among gram-negative isolates collected in the USA between 2005 and 2011 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.)","volume":"12","author":"Denys","year":"2013","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"Suppl 6","key":"10.1016\/j.jgar.2019.11.011_bib0020","doi-asserted-by":"crossref","first-page":"S381","DOI":"10.1093\/cid\/ciu593","article-title":"Bad bugs need old drugs: a stewardship program\u2019s evaluation of minocycline for multidrug-resistant Acinetobacter baumannii infections","volume":"59","author":"Goff","year":"2014","journal-title":"Clin Infect Dis"},{"issue":"Suppl 6","key":"10.1016\/j.jgar.2019.11.011_bib0025","doi-asserted-by":"crossref","first-page":"S374","DOI":"10.1093\/cid\/ciu613","article-title":"A review of intravenous minocycline for treatment of multidrug-resistant Acinetobacter infections","volume":"59","author":"Ritchie","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2019.11.011_bib0030","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/jps.23872","article-title":"Determination of atypical nonlinear plasma-protein-binding behavior of tigecycline using an in vitro microdialysis technique","volume":"103","author":"Mukker","year":"2014","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.jgar.2019.11.011_bib0035","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1128\/AAC.00240-16","article-title":"Eravacycline Pharmacokinetics and Challenges in Defining Humanized Exposure In Vivo","volume":"60","author":"Thabit","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2019.11.011_bib0040","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/jac\/dkx039","article-title":"The complexity of minocycline serum protein binding","volume":"72","author":"Zhou","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2019.11.011_bib0045","first-page":"e02371","article-title":"Pharmacokinetics and Pharmacodynamics of Minocycline against Acinetobacter baumannii in a Neutropenic Murine Pneumonia Model","volume":"61","author":"Zhou","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2019.11.011_bib0050","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1128\/AAC.01815-15","article-title":"Analytical and functional determination of polymyxin B protein binding in serum","volume":"59","author":"Abodakpi","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2019.11.011_bib0055","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/cpt1973145852","article-title":"Pharmacokinetic studies on minocycline in man","volume":"14","author":"Macdonald","year":"1973","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jgar.2019.11.011_bib0060","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00003088-199732020-00002","article-title":"The clinical pharmacokinetics of levofloxacin","volume":"32","author":"Fish","year":"1997","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jgar.2019.11.011_bib0065","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1128\/AAC.03535-14","article-title":"Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors","volume":"58","author":"Blanchard","year":"2014","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716519303030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716519303030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:57:08Z","timestamp":1761991028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716519303030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":13,"alternative-id":["S2213716519303030"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2019.11.011","relation":{},"ISSN":["2213-7165"],"issn-type":[{"type":"print","value":"2213-7165"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of serum protein binding on bacterial killing of minocycline","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2019.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}